Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding
By Robert C. C. Mercer, Nhat T. T. Le, Mei C. Q. Houser, Aaron B. Beeler, and David A. Harris Excerpt from the article published in bioRxiv 2023.11.28.569035; November 29, 2023. DOI: https://doi.org/10.1101/2023.11.28.569035 Editor’s Highlights Abstract Prion diseases are invariably fatal neurodegenerative diseases of humans and other animals for which there are no treatment options. Previous work from […]
Continue ReadingSigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors
By M. Carmen Ruiz-Cantero, Miguel Á. Huerta, Miguel Á. Tejada, Miriam Santos-Caballero, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Entrena, José M. Baeyens, and Enrique J. Cobos Excerpt from the article published in Biomedicine & Pharmacotherapy, Volume 167, November 2023,115534, ISSN 0753-3322, DOI: https://doi.org/10.1016/j.biopha.2023.115534. Highlights Abstract The analgesic effects of sigma-1 antagonists are undisputed, but the effects […]
Continue ReadingMitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS
By Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, and Koji Yamanaka Excerpt from the article published in Proceedings of the National Academy of Sciences, November 15, 2023, 120 (47) e2315347120, DOI: https://doi.org/10.1073/pnas.2315347120 Editor’s Highlights Significance Recent studies, including ours, have suggested that mitochondria-associated membrane (MAM) disruption is a common pathogenic mechanism in amyotrophic lateral sclerosis (ALS). In the […]
Continue ReadingA Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain
By Bin Shen, Daehyun Yoon, Jessa Castillo, and Sandip Biswal Excerpt from the article published in Semin Musculoskelet Radiol, November 2023; 27(06): 601-617 DOI: 10.1055/s-0043-1775744 Editor’s Highlights Abstract Accurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from […]
Continue ReadingSigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain
By Simona Denaro, Lorella Pasquinucci, Rita Turnaturi, Cristiana Alberghina, Lucia Longhitano, Sebastiano Giallongo, Giuliana Costanzo, Salvatore Spoto, Margherita Grasso, Agata Zappalà, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti, and Carmela Parenti Excerpt from the article published in Mol Neurobiol (November 3, 2023). DOI: https://doi.org/10.1007/s12035-023-03717-w Editor’s Highlights Abstract Neuropathic pain is one of the most […]
Continue ReadingSigma1 Regulates Lipid Droplet–Mediated Redox Homeostasis Required for Prostate Cancer Proliferation
By Halley M. Oyer; Alexandra R. Steck; Charles G. Longen; Sanjana Venkat; Konuralp Bayrak; Eleanor B. Munger; Dan Fu; Paola A. Castagnino; Christina M. Sanders; Nathalia A. Tancler; My T. Mai; Justin P. Myers; Matthew J. Schiewer; Nan Chen; Elahe A. Mostaghel; and Felix J. Kim Excerpt from the article published in Cancer Research Communications (October […]
Continue ReadingMulti-Omics Analysis Reveals the Role of Sigma-1 Receptor in a Takotsubo-like Cardiomyopathy Model
By Yi Liu, Qing Chen, Jian-Zheng Yang, Xiu-Wen Li, Li-Jian Chen, Kai-Kai Zhang, Jia-Li Liu, Jia-Hao Li, Clare Hsu, Long Chen, Jia-Hao Zeng, Qi Wang, Dong Zhao, and Jing-Tao Xu Excerpt from the article published in Biomedicines. 12 October 2023; 11(10):2766. DOI: https://doi.org/10.3390/biomedicines11102766 Editor’s Highlights Abstract Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy that presents […]
Continue ReadingGenetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice
By Sergio López-Estévez, Mònica Aguilera, Georgia Gris, Beatriz de la Puente, Alicia Carceller, and Vicente Martínez Excerpt from the article published in Biomedicines. 12 October 2023; 11(10):2758. DOI: https://doi.org/10.3390/biomedicines11102758 Editor’s Highlights Abstract Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute colitis-associated hypersensitivity using […]
Continue ReadingSigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors
By M. Carmen Ruiz-Cantero, Miguel Á. Huerta, Miguel Á. Tejada, Miriam Santos-Caballero, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Entrena, José M. Baeyens, and Enrique J. Cobos Excerpt from the article published in Biomedicine & Pharmacotherapy, Volume 167, November 2023, 115534, ISSN 0753-3322, DOI: https://doi.org/10.1016/j.biopha.2023.115534. Highlights Abstract The analgesic effects of sigma-1 antagonists are undisputed, but the […]
Continue ReadingSigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis
By Nhi T. Nguyen, Valeria Jaramillo-Martinez, Marilyn Mathew, Varshini V. Suresh, Sathish Sivaprakasam, Yangzom D. Bhutia, and Vadivel Ganapathy Excerpt from the article published in International Journal of Molecular Sciences. 28 September 2023; 24(19):14672. DOI: https://doi.org/10.3390/ijms241914672 Editor’s Higlights Abstract Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or heme and also several unrelated xenobiotics/chemicals. They […]
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