We develop advanced therapeutics to treat disorders that are largely unmet

Current focus on neurological disorders

Alzheimer’s Disease

Alzheimer’s disease is a progressive neurological disorder that begins with subtle cognitive changes and progressively leads to severe impairment of memory, thinking, speech, spatial awareness, and independence, culminating in profound dementia that devastates the patient’s quality of life and life span.
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Huntington’s Disease

Huntington’s disease is a rare inherited disorder from a genetic mutation causing brain neuron degeneration. The neurons become increasingly stressed and lose their ability to communicate, which manifests in functional, motor, cognitive, emotional, and behavioral symptoms.
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Substance Use Disorder

Substance use disorder is a mental health condition in which a person has a problematic pattern of substance use that causes distress and impairs their life. It typically involves an overpowering desire to use the substance, increased tolerance to the substance, and withdrawal symptoms when you stop taking it.
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Parkinson’s Disease

Parkinson’s disease is a progressive neurodegenerative disorder whose motor symptoms may include slowness of movement, rigidity, tremors, and impaired balance, while non-motor symptoms may include cognitive and sleep impairment, depression, and dementia.
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Fragile X Syndrome

Fragile X syndrome is the most common genetic form of intellectual disability and autism spectrum disorder, affecting primarily males. Altered synaptic structure and function of neuronal cells result in anxiety, hypersensitivity, seizures, repetitive behaviors, cognitive inflexibility, and social-behavioral impairment.
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Neuropathic Cancer Pain

Neuropathic cancer pain is caused by direct damage to the nervous system by cancer itself or treatments such as chemotherapy, radiation therapy o surgery. The pain is often associated with decreased sensation, impaired balance, and motor weakness.
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New therapeutic areas under study

Cardiovascular Diseases

Cardiovascular diseases are a group of disorders of the heart and blood vessels that include vascular diseases of the brain, pulmonary embolism, and rare congenital heart diseases, and together they are the leading cause of death worldwide. Some cardiovascular and ocular diseases share underlying mechanisms.
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Aging

Adult neurogenesis, the process by which neurons are generated in the adult brain, and overall body protein lifetimes decrease in an age-dependent manner. Improving neurogenesis and regulating altered proteostasis could help in the fight against neurodegeneration and cognitive decline and could increase human lifespan.
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Mental disorders

A mental disorder is characterized by a clinically significant disturbance in an individual’s cognition, emotional regulation, or behavior. It is usually associated with distress or impairment in important areas of functioning. Major depression and anxiety are two of the major mental disorders that have some overlapping pathophysiologies,
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Cancer

In cancer, numerous mechanisms evade regulatory circuits. In addition to increased angiogenesis, the progression of the pathology is favored by the production of growth factors and insensitivity to anti-growth factors; the ability to evade apoptosis, and to escape from the primary tumor mass to create metastases.
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Metabolic Diseases

Metabolic diseases such as obesity, diabetes, cholesterol, or fatty liver are characterized by lipid metabolism dysfunctions. Unraveling the lipid metabolism pathways, which converge in motor neuron degenerative diseases, and the development of mechanisms to prevent lipid abnormalities will prevent metabolic diseases.
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Epilepsy

Epilepsy is a brain disorder in which clusters of neuronal cells sometimes signal abnormally. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior, or sometimes convulsions, muscle spasms, and loss of consciousness.
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Osteoarthritis Pain

Osteoarthritis is the most common musculoskeletal disease among adults, often characterized by chronic pain and disability. There is no cure for osteoarthritis. Osteoarthritis chronic pain severely affects the patient’s quality of life and imposes a great economic burden on individuals, families, and the entire society.
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Autoimmune Diseases

Autoimmune diseases are defined as the loss of tolerance to self-antigens in which the immune system attacks healthy tissues in an individual. While there are different characteristics of expression amongst the types of autoimmune and inflammatory disorders, there are many shared mechanisms of action and origins.
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Antiviral

Outbreaks of emerging infections face the unique challenge of treating patients when there has not yet been time to discover new vaccines, so there is an urgent need to develop safe, inexpensive, orally administered antiviral drugs to curb infection in at-risk populations and reduce the severity of damage caused by new viruses.
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