Sigma 1 receptor - Advantx Pharmaceuticals Inc.

N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk

By Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang, and Zhang-Jin Zhang Excerpt from the article published in Alzheimer’s Research & Therapy volume 16, 95, 01 May 2024, DOI: https://doi.org/10.1186/s13195-024-01462-3 Abstract Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology […]

Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction

By Remex Naznin Sultana , Abdullah Chowdhury S. , Aishwarya Richa , Kolluru Gopi K. , Traylor James , Bhuiyan Mohammad Alfrad Nobel , Kevil Christopher G. , Orr A. Wayne , Rom Oren , Pattillo Christopher B. , and Bhuiyan Md. Shenuarin Excerpt of the article published in Frontiers in Physiology, 15, 29 April […]

Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus

By Peng Ren, Jing-Ya Wang, Hong-Lei Chen, Yue Wang, Lin-Yu Cui, Jing-Yao Duan, Wen-Zhi Guo, Yong-Qi Zhao, and Yun-Feng Li Excerpt from the article published in Journal of Pharmacological Sciences, Volume 154, Issue 4, April 2024, Pages 236-245, ISSN 1347-8613, DOI: https://doi.org/10.1016/j.jphs.2024.02.003. Abstract Postpartum depression (PPD) is a significant contributor to maternal morbidity and mortality. […]

Single cocaine exposure attenuates the intrinsic excitability of CRH neurons in the ventral BNST via Sigma-1 receptors

By Jintao Wu and Yue Zhao Excerpt from the article published in Translational Neuroscience, vol. 15, no. 1, April 24, 2024, pp. 20220339. DOI: https://doi.org/10.1515/tnsci-2022-0339 Abstract The ventral bed nucleus of the stria terminalis (vBNST) plays a key role in cocaine addiction, especially relapse. However, the direct effects of cocaine on corticotropin-releasing hormone (CRH) neurons […]

Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress

By Simon Couly, Yuko Yasui, Semnyonga Foncham, Ioannis Grammatikakis, Ashish Lal, Lei Shi, and Tsung-Ping Su Excerpt from the article published in Cellular and Molecular Life Sciences, Article 81, 14 (2024). Published 09 January 2024. DOI: https://doi.org/10.1007/s00018-023-05023-z Editor’s Highlights Abstract Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone present on the endoplasmic reticulum (ER) membrane. […]

Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB

By Chun-Yu Lin, Hsiang-En Wu, Eddie Feng-Ju Weng, Hsuan-Cheng Wu, Tsung-Ping Su, and Shao-Ming Wang Excerpt from the article published in Molecular Neurobioligy (2024). 05 January 2024. DOI: https://doi.org/10.1007/s12035-023-03885-9 Editor’s Highlights Abstract Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which currently have no cure. Recent […]

The Protective Role of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Protein Sigma-1 Receptor in Regulating Endothelial Inflammation and Permeability Associated with Acute Lung Injury

By Zahra Mahamed, Mohammad Shadab, Rauf Ahmad Najar, Michelle Warren Millar, Jashandeep Bal, Traci Pressley, and Fabeha Fazal Excerpt from the article published in Cells. 2024; 13(1):5. 19 December 2023, DOI: https://doi.org/10.3390/cells13010005 Editor’s Highlights Abstract Earlier studies from our lab identified endoplasmic reticulum (ER) chaperone BiP/GRP78, an important component of MAM, to be a novel determinant […]

Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels

By Hui Ma, Jin-feng Li, Xin Qiao, Yue Zhang, Xiao-juan Hou, Hai-xia Chang, Hong-lei Chen, Yong Zhang, and Yun-feng Li Excerpt from the article published in Acta Pharmacologica Sinica 45, 704–713 (2024). DOI: https://doi.org/10.1038/s41401-023-01201-8 Abstract Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, […]

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

By Kaikai Zhang, Lijian Chen, Jianzheng Yang, Jiali Liu, Jiahao Li, Yi Liu, Xiuwen Li, Long Chen, Clare Hsu, Jiahao Zeng, Xiaoli Xie, and Qi Wanga Excerpt from the article published in Acta Pharm Sin B. 2023 Dec;13(12):4801-4822. Epub 2023 Sep 21. PMID: 38045052; PMCID: PMC10692394. DOI: 10.1016/j.apsb.2023.09.010 Editor’s Highlights Abstract Methamphetamine (Meth) abuse can […]

Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding

By Robert C. C. Mercer, Nhat T. T. Le, Mei C. Q. Houser, Aaron B. Beeler, and David A. Harris Excerpt from the article published in bioRxiv 2023.11.28.569035; November 29, 2023. DOI: https://doi.org/10.1101/2023.11.28.569035 Editor’s Highlights Abstract Prion diseases are invariably fatal neurodegenerative diseases of humans and other animals for which there are no treatment options. Previous work from […]

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