Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson’s Disease
By Talha Siddiqui and Lokesh Kumar Bhatt Excerpt from the article published in Neurochem Research. 31 May 2023. DOI: https://doi.org/10.1007/s11064-023-03960-6 Editor’s Highlights Abstract Parkinson’s disease is a neurodegenerative disease affecting mainly the elderly population. It is characterized by the loss of dopaminergic neurons of the substantia nigra pars compacta region. Parkinson’s disease patients exhibit motor […]
Continue ReadingUbiquilin-2 regulates pathological alpha-synuclein
By Stephanie S. Sandoval-Pistorius, Julia E. Gerson, Nyjerus Liggans, Jaimie H. Ryou, Kulin Oak, Xingli Li, Keyshla Y. Negron-Rios, Svetlana Fischer, Henry Barsh, Emily V. Crowley, Mary E. Skinner, Lisa M. Sharkey, Sami J. Barmada, and Henry L. Paulson Excerpt from the article published in Scientific Reports 13, 293 (2023). 06 January 2023, DOI: https://doi.org/10.1038/s41598-022-26899-0 Editor’s […]
Continue ReadingChaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection
By Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 24, no. 1: 823. 3 January 2023, DOI: https://doi.org/10.3390/ijms24010823 Editor’s Highlights Abstract Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease […]
Continue ReadingImpaired migratory phenotype of CD4+ T cells in Parkinson’s disease
By Dejan Mamula, Shervin Khosousi, Yachao He, Vesna Lazarevic, and Per Svenningsson Excerpt from the article published in NPJ Parkinsons Dis. 8, 171, 10 December 2022. DOI: https://doi.org/10.1038/s41531-022-00438-0 Editor’s Highlights Abstract Dysfunctions in the immune system appear implicated in both disease onset and progression of Parkinson’s disease (PD). Neurodegeneration observed in the brain of PD patients has […]
Continue ReadingA postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease
By Per Borghammer, Mie Kristine Just, Jacob Horsager, Casper Skjærbæk, Anna Raunio, Eloise H. Kok, Sara Savola, Shigeo Murayama, Yuko Saito, Liisa Myllykangas, and Nathalie Van Den Berge Excerpt from the article published in npj-Parkinson’s Disease. 8, 166, 30 November 2022, DOI: https://doi.org/10.1038/s41531-022-00436-2 Editor’s Highlights Abstract The dual-hit hypothesis of Parkinson’s disease (PD) originally postulated that […]
Continue ReadingMitochondrial biogenesis, telomere length and cellular senescence in Parkinson’s disease and Lewy body dementia
By Muhammad Asghar, Amani Odeh, Ahmad Jouni Fattahi, Alexandra Edwards Henriksson, Aurelie Miglar, Shervin Khosousi, and Per Svenningsson Excerpt from the article published in Scientific Reports 12, 17578, 20 October 2022, DOI: https://doi.org/10.1038/s41598-022-22400-z Editor’s Highlights Although Parkinson’s disease (PD) is a complex disease with several causes, including genetic and environmental factors, progressive age remains the single […]
Continue ReadingSmall soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
By Derya Emin, Yu P. Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I. Sideris, Jeff Y. L. Lam, Rohan T. Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P. J. Knowles, Michele Vendruscolo, Francesco S. Ruggeri, Franklin I. Aigbirhio, Caroline H. Williams-Gray, and David Klenerman Excerpt from the article published […]
Continue ReadingAge-dependent neurodegeneration and neuroinflammation in a genetic A30P/A53T double-mutated α-synuclein mouse model of Parkinson’s disease
By Lisa Rauschenberger, Jennifer Behnke, Alexander Grotemeyer, Susanne Knorr, Jens Volkmann, and Chi Wang Excerpt from the article published in Neurobiology of Disease, Volume 171, September 2022, 105798, ISSN 0969-9961, DOI: https://doi.org/10.1016/j.nbd.2022.105798. Editor’s Highlights Authors’ Highlights Abstract The pathogenesis of Parkinson’s disease (PD) is closely interwoven with the process of aging. Moreover, increasing evidence from human postmortem […]
Continue ReadingLysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
By Ying Xue Xie, Nima N. Naseri, Jasmine Fels, Parinati Kharel, Yoonmi Na, Diane Lane, Jacqueline Burré, and Manu Sharma Excerpt from the article published in Nature Communications 13, 4918, 22 August 2022, DOI: https://doi.org/10.1038/s41467-022-32625-1 Editor’s Highlights The release of pathogenic aggregates of the neuronal protein α-Synuclein (αSyn) into the extracellular space instigate the neuron-to-neuron transmission […]
Continue ReadingTargeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders
By Jing Li, Bowen Jia, Ying Cheng, Yiting Song, Qianqian Li, and Chengliang Luo Excerpt from the article published in Oxidative Medicine and Cellular Longevity, Volume 2022, Article ID 3999083, Published 22 Jul 2022, DOI: https://doi.org/10.1155/2022/3999083 Editor’s Highlights Abstract As a novel mode of regulated cell death (RCD), ferroptosis was firstly proposed by Dixon in 2012 [1]. With […]
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