Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke
By Gufang Zhang, Qi Li, Weijie Tao, Pingping Qin, Jiali Chen, Huicui Yang, Jiaojiao Chen, Hua Liu, Qijun Dai, and Xuechu Zhen Excerpt from the article published in Theranostics. 2023 Jan 1;13(2):543-559. DOI: 10.7150/thno.77088. PMID: 36632219; PMCID: PMC9830433. Editor’s Highlights Abstract Background: Efferocytosis of apoptotic neurons by macrophages is essential for the resolution of inflammation and […]
Continue ReadingFMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability
By Annunziata D’Elia, Sara Schiavi, Antonia Manduca, Alessandro Rava, Valeria Buzzelli, Fabrizio Ascone, Tiziana Orsini, Sabrina Putti, Andrea Soluri, Filippo Galli, Alessandro Soluri, Maurizio Mattei, Rosella Cicconi, Roberto Massari, and Viviana Trezza Excerpt from the article published in Scientific Reports 12, 22535, 29 December 2022. DOI: https://doi.org/10.1038/s41598-022-26986-2 Editor’s Highlights Abstract Autism Spectrum Disorder (ASD) is a […]
Continue ReadingαN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers
By Javier Garzón-Niño, Elsa Cortés-Montero, María Rodríguez-Muñoz, and Pilar Sánchez-Blázquez Excerpt from the article published in the International Journal of Molecular Sciences. 2023; 24(1):582, 29 December 2022, DOI: https://doi.org/10.3390/ijms24010582 Editor’s Highlights Abstract The opioid peptide β-endorphin coexists in the pituitary and brain in its αN-acetylated form, which does not bind to opioid receptors. We now report […]
Continue ReadingBrain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration
By Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, and Thomas K Karikari Excerpt from the article published in Brain, 27 December 2022; awac407, DOI: https://doi.org/10.1093/brain/awac407 Editor’s Highlights Abstract Blood-based […]
Continue ReadingSigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes
By Hideaki Tagashira, Md. Shenuarin Bhuiyan, Yasuharu Shinoda, Ichiro Kawahata, Tomohiro Numata, and Kohji Fukunaga Introduction to the article published in Journal of Pharmacological Sciences, December 10, 2022, ISSN 1347-8613, DOI: https://doi.org/10.1016/j.jphs.2022.12.005. Editor’s Highlights Abstract The Sigma-1 receptor (Sigmar1) is downregulated in heart failure model mice with mitochondrial dysfunction. However, the mechanism in detail has […]
Continue ReadingMitochondria in Huntington’s disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies
By Ana Maria Jurcau, and Carolina Maria Jurcau Excerpt from the article published in Neural Regeneration Research 18(7):p 1472-1477, July 2023. | DOI: 10.4103/1673-5374.360289 Editor’s Highlights Abstract Huntington’s disease is a genetic disease caused by expanded CAG repeats on exon 1 of the huntingtin gene located on chromosome 4. Compelling evidence implicates impaired mitochondrial energetics, […]
Continue ReadingAmyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation
By Richard J. Mead, Ning Shan, H. Joseph Reiser, Fiona Marshall, and Pamela J. Shaw Excerpt from the article published in Nature Reviews Drug Discovery, 21 December 2022. DOI: https://doi.org/10.1038/s41573-022-00612-2 Abstract Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of motor neurons. As with all major neurodegenerative disorders, development of disease-modifying therapies […]
Continue ReadingDecoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks
By Bárbara Avelar-Pereira, Michael E. Belloy, Ruth O’Hara, and S. M. Hadi Hosseini for the Alzheimer’s Disease Neuroimaging Initiative Excerpt from the article published in Molecular Psychiatry. 20 December 2022, DOI: https://doi.org/10.1038/s41380-022-01886-z Editor’s Highlights Abstract Alzheimer’s disease (AD) is a multifactorial and heterogeneous disorder, which makes early detection a challenge. Studies have attempted to combine […]
Continue ReadingHuntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
By Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, […]
Continue ReadingRetinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
By Timur A. Mavlyutov, Jing Li, Xinying Liu, Hongtao Shen, Huan Yang, Christopher R. McCurdy, Bikash Pattnaik, and Lian-Wang Guo Excerpt from the article published in Genes 13(12):2386, 16 December 2022, DOI: https://doi.org/10.3390/genes13122386 Editor’s Highlights Abstract The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding […]
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