Activation of the sigma-1 receptor ameliorates neuronal ferroptosis via IRE1α after spinal cord injury
By Rui Tan, Chunxiao Sui, Yuhang Diao, Guihong Shi, Xiaojun Hu, Zhenghao Hao, Chenyang Li, Mingyu Hao, Minghao Xie, and Tao Zhu Excerpt from the article published in Brain Research, May 18 2024, 149011, ISSN 0006-8993, DOI:https://doi.org/10.1016/j.brainres.2024.149011. Highlights Abstract Spinal Cord Injury (SCI) is a debilitating disease associated with a significant economic burden owing to […]
Continue ReadingCytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress
By Rony Takchi, Bethany C. Prudner, Qingqing Gong, Takaomi Hagi, Kenneth F. Newcomer, Linda X. Jin, Suwanna Vangveravong, Brian A. Van Tine, William G. Hawkins, and Dirk Spitzer Excerpt from the article published in Cell Death & Disease volume 15, Article number: 309, 02 May 2024, DOI: https://doi.org/10.1038/s41419-024-06693-8 Abstract Sigma-2-ligands (S2L) are characterized by high […]
Continue ReadingN, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk
By Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang, and Zhang-Jin Zhang Excerpt from the article published in Alzheimer’s Research & Therapy volume 16, 95, 01 May 2024, DOI: https://doi.org/10.1186/s13195-024-01462-3 Abstract Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology […]
Continue ReadingDeletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction
By Remex Naznin Sultana , Abdullah Chowdhury S. , Aishwarya Richa , Kolluru Gopi K. , Traylor James , Bhuiyan Mohammad Alfrad Nobel , Kevil Christopher G. , Orr A. Wayne , Rom Oren , Pattillo Christopher B. , and Bhuiyan Md. Shenuarin Excerpt of the article published in Frontiers in Physiology, 15, 29 April […]
Continue ReadingActivation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus
By Peng Ren, Jing-Ya Wang, Hong-Lei Chen, Yue Wang, Lin-Yu Cui, Jing-Yao Duan, Wen-Zhi Guo, Yong-Qi Zhao, and Yun-Feng Li Excerpt from the article published in Journal of Pharmacological Sciences, Volume 154, Issue 4, April 2024, Pages 236-245, ISSN 1347-8613, DOI: https://doi.org/10.1016/j.jphs.2024.02.003. Abstract Postpartum depression (PPD) is a significant contributor to maternal morbidity and mortality. […]
Continue ReadingSingle cocaine exposure attenuates the intrinsic excitability of CRH neurons in the ventral BNST via Sigma-1 receptors
By Jintao Wu and Yue Zhao Excerpt from the article published in Translational Neuroscience, vol. 15, no. 1, April 24, 2024, pp. 20220339. DOI: https://doi.org/10.1515/tnsci-2022-0339 Abstract The ventral bed nucleus of the stria terminalis (vBNST) plays a key role in cocaine addiction, especially relapse. However, the direct effects of cocaine on corticotropin-releasing hormone (CRH) neurons […]
Continue ReadingTransmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
By Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire […]
Continue ReadingBenzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress
By Simon Couly, Yuko Yasui, Semnyonga Foncham, Ioannis Grammatikakis, Ashish Lal, Lei Shi, and Tsung-Ping Su Excerpt from the article published in Cellular and Molecular Life Sciences, Article 81, 14 (2024). Published 09 January 2024. DOI: https://doi.org/10.1007/s00018-023-05023-z Editor’s Highlights Abstract Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone present on the endoplasmic reticulum (ER) membrane. […]
Continue ReadingFluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB
By Chun-Yu Lin, Hsiang-En Wu, Eddie Feng-Ju Weng, Hsuan-Cheng Wu, Tsung-Ping Su, and Shao-Ming Wang Excerpt from the article published in Molecular Neurobioligy (2024). 05 January 2024. DOI: https://doi.org/10.1007/s12035-023-03885-9 Editor’s Highlights Abstract Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which currently have no cure. Recent […]
Continue ReadingHighly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response
By Muhammad Saad Yousuf, James J. Sahn, Hongfen Yang, Eric T. David, Stephanie Shiers, Marisol Mancilla Moreno, Jonathan Iketem, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Subhaan M. Mian, Ayesha Ahmad, Benedict J. Kolber, Daniel J. Liebl, Stephen F. Martin, and Theodore J. Price Excerpt from the article published in Proceedings […]
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