Category Archives: Scientific Papers

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

By Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire […]

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Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress

Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress

By Simon Couly, Yuko Yasui, Semnyonga Foncham, Ioannis Grammatikakis, Ashish Lal, Lei Shi, and Tsung-Ping Su Excerpt from the article published in Cellular and Molecular Life Sciences, Article 81, 14 (2024). Published 09 January 2024. DOI: https://doi.org/10.1007/s00018-023-05023-z Editor’s Highlights Abstract Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone present on the endoplasmic reticulum (ER) membrane. […]

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Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB

Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB

By Chun-Yu Lin, Hsiang-En Wu, Eddie Feng-Ju Weng, Hsuan-Cheng Wu, Tsung-Ping Su, and Shao-Ming Wang Excerpt from the article published in Molecular Neurobioligy (2024). 05 January 2024. DOI: https://doi.org/10.1007/s12035-023-03885-9 Editor’s Highlights Abstract Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which currently have no cure. Recent […]

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The Protective Role of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Protein Sigma-1 Receptor in Regulating Endothelial Inflammation and Permeability Associated with Acute Lung Injury

The Protective Role of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Protein Sigma-1 Receptor in Regulating Endothelial Inflammation and Permeability Associated with Acute Lung Injury

By Zahra Mahamed, Mohammad Shadab, Rauf Ahmad Najar, Michelle Warren Millar, Jashandeep Bal, Traci Pressley, and Fabeha Fazal Excerpt from the article published in Cells. 2024; 13(1):5. 19 December 2023, DOI: https://doi.org/10.3390/cells13010005 Editor’s Highlights Abstract Earlier studies from our lab identified endoplasmic reticulum (ER) chaperone BiP/GRP78, an important component of MAM, to be a novel determinant […]

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Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

By Kaikai Zhang, Lijian Chen, Jianzheng Yang, Jiali Liu, Jiahao Li, Yi Liu, Xiuwen Li, Long Chen, Clare Hsu, Jiahao Zeng, Xiaoli Xie, and Qi Wanga Excerpt from the article published in Acta Pharm Sin B. 2023 Dec;13(12):4801-4822. Epub 2023 Sep 21. PMID: 38045052; PMCID: PMC10692394. DOI: 10.1016/j.apsb.2023.09.010 Editor’s Highlights Abstract Methamphetamine (Meth) abuse can […]

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TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth

TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth

By Yuanqin Zhang, Xiangwei Fang, Jiuhui Wang and Daotai Nie Excerpt from the article published in Cancers 2023, 15(23): 5691. 2 December 2023. DOI: https://doi.org/10.3390/cancers15235691 Editor’s Highlitghts Simple Summary Selective estrogen receptor modulators are a major treatment modality for estrogen receptor-positive breast cancers, but the emergence of resistance or a lack of initial responsiveness is a […]

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Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding

Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding

By Robert C. C. Mercer, Nhat T. T. Le, Mei C. Q. Houser, Aaron B. Beeler, and David A. Harris Excerpt from the article published in bioRxiv 2023.11.28.569035; November 29, 2023. DOI: https://doi.org/10.1101/2023.11.28.569035 Editor’s Highlights Abstract Prion diseases are invariably fatal neurodegenerative diseases of humans and other animals for which there are no treatment options. Previous work from […]

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Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

By M. Carmen Ruiz-Cantero, Miguel Á. Huerta, Miguel Á. Tejada, Miriam Santos-Caballero, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Entrena, José M. Baeyens, and Enrique J. Cobos Excerpt from the article published in Biomedicine & Pharmacotherapy, Volume 167, November 2023,115534, ISSN 0753-3322, DOI: https://doi.org/10.1016/j.biopha.2023.115534. Highlights Abstract The analgesic effects of sigma-1 antagonists are undisputed, but the effects […]

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Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS

Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS

By Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, and Koji Yamanaka Excerpt from the article published in Proceedings of the National Academy of Sciences, November 15, 2023, 120 (47) e2315347120, DOI: https://doi.org/10.1073/pnas.2315347120 Editor’s Highlights Significance Recent studies, including ours, have suggested that mitochondria-associated membrane (MAM) disruption is a common pathogenic mechanism in amyotrophic lateral sclerosis (ALS). In the […]

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