FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin–proteasome system
By Hideo Shimizu, and Hirohiko Hohjoh Excerpt from the article published in Scientific Reports 13, 1956, 02 February 2023, DOI: https://doi.org/10.1038/s41598-023-29152-4 Editor’s Highlights Abstract The ubiquitin–proteasome system (UPS) is a proteolytic pathway that is essential for life maintenance and vital functions, and its disruption causes serious impairments, e.g., disease development. Thus, the UPS is properly regulated. Here […]
Continue ReadingSigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis
By Seiji Watanabe, Mai Horiuchi, Yuri Murata, Okiru Komine, Noe Kawade, Akira Sobue, and Koji Yamanaka Excerpt from the article published in Neurobiology of Disease, 2 February 2023, 106031, ISSN 0969-9961, DOI: https://doi.org/10.1016/j.nbd.2023.106031 Editor’s Highlights Autors’ Highlights Abstract Organelle contact sites are multifunctional platforms for maintaining cellular homeostasis. Alternations of the mitochondria-associated membranes (MAM), one […]
Continue ReadingTRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
By Aida Marcotti, Jorge Fernández-Trillo, Alejandro González, Marta Vizcaíno-Escoto, Pablo Ros-Arlanzón, Luz Romero, José Miguel Vela, Ana Gomis, Félix Viana, and Elvira de la Peña Excerpt from the article published in Brain, Volume 146, Issue 2, February 2023, Pages 475–491, DOI: https://doi.org/10.1093/brain/awac273 Editor’s Highlights Abstract Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer […]
Continue ReadingSigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases
By Francisco Javier Munguia-Galaviz, Alejandra Guillermina Miranda-Diaz, Miguel Alejandro Cardenas-Sosa, and Raquel Echavarria Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1997. DOI: https://doi.org/10.3390/ijms24031997 Editor’s Hihghlights Abstract Cardiovascular and renal diseases are among the leading causes of death worldwide, and regardless of current efforts, there is a demanding […]
Continue ReadingOverview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection
By Véronik Lachance, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, and Saïd Kourrich Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1971. DOI: https://doi.org/10.3390/ijms24031971 Editor’s Highlights Abstract For the past several years, fundamental research on Sigma-1R (S1R) […]
Continue ReadingUbiquilin-2 regulates pathological alpha-synuclein
By Stephanie S. Sandoval-Pistorius, Julia E. Gerson, Nyjerus Liggans, Jaimie H. Ryou, Kulin Oak, Xingli Li, Keyshla Y. Negron-Rios, Svetlana Fischer, Henry Barsh, Emily V. Crowley, Mary E. Skinner, Lisa M. Sharkey, Sami J. Barmada, and Henry L. Paulson Excerpt from the article published in Scientific Reports 13, 293 (2023). 06 January 2023, DOI: https://doi.org/10.1038/s41598-022-26899-0 Editor’s […]
Continue ReadingAβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
By Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, […]
Continue ReadingChaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection
By Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 24, no. 1: 823. 3 January 2023, DOI: https://doi.org/10.3390/ijms24010823 Editor’s Highlights Abstract Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease […]
Continue ReadingSigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus
By Wenjing Song, Yang Yao, Heling Zhang, Xin Hao, Liping Zhou, Zhixiao Song, Tiantian Wei, Tianyan Chi, Peng Liu, Xuefei Ji, and Libo Zou Excerpt from the article published in Molecules 2023, 28(1), 390; 2 January 2023; DOI: https://doi.org/10.3390/molecules28010390 Editor’s Highlights Abstract Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in […]
Continue ReadingSigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress
By Mengyu Du, Tao Jiang, Shuxuan He Bo Cheng, Xin Zhang, Liya Li, Lan Yang, Wei Gao, Yansong Li, and Qiang Wang Excerpt from the article published in Cells 2023, 12(1), 197; 3 January 2023, DOI: https://doi.org/10.3390/cells12010197 Editor’s Highlights Abstract The prevalence of diabetes-associated cognitive dysfunction (DACD) has increased to 13.5%. Dementia, as the most severe DACD, […]
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