Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis
By Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu, and Bo Yang Excerpt from the article published in Molecular Medicine volume 28, Article number: 87, 03 August 2022, DOI: https://doi.org/10.1186/s10020-022-00517-1 Editor’s Highlights With the increase of global aging population, the incidence of Heart Failure (HF) has increased […]
Continue ReadingAβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
By Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis Jr, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, and Franck Polleux Excerpt from the article published in Nature Communications 13, 4444, 01 August 2022, DOI: https://doi.org/10.1038/s41467-022-32130-5 Editor’s Highlights *Note: Sigma-1 receptors regulate inositol 1,4,5-trisphosphate (IP3) channels and interact […]
Continue ReadingTMEM97 is transcriptionally activated by YY1 and promotes colorectal cancer progression via the GSK-3β/β-catenin signaling pathway
By Dong Mao, Xiaowei Zhang, Zhaoping Wang, Guannan Xu, and Yun Zhang Introduction to the article published in Human Cell (2022). 30 July 2022, DOI: https://doi.org/10.1007/s13577-022-00759-5 Editor’s Highlights Transmembrane protein 97 (TMEM97), also known as meningioma-associated protein (MAC30) or sigma-2 receptor functions in cell proliferation, apoptosis, migration, and invasion. Abstract Transmembrane protein 97 (TMEM97) is a conserved integral membrane protein highly […]
Continue ReadingPGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
By Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, and Kazuhiro Tamura Excerpt from the article published in Biomolecules 2022, 12, 1046, 28 July 2022, DOI: https://doi.org/10.3390/biom12081046 Editor’s Highlights The differentiation of endometrial stromal cells (ESCs) into decidual cells is essential for the acquisition of endometrial receptivity for implantation and subsequent […]
Continue ReadingTargeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders
By Jing Li, Bowen Jia, Ying Cheng, Yiting Song, Qianqian Li, and Chengliang Luo Excerpt from the article published in Oxidative Medicine and Cellular Longevity, Volume 2022, Article ID 3999083, Published 22 Jul 2022, DOI: https://doi.org/10.1155/2022/3999083 Editor’s Highlights Abstract As a novel mode of regulated cell death (RCD), ferroptosis was firstly proposed by Dixon in 2012 [1]. With […]
Continue ReadingAmyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases
By Urmi Senguptaab, and Rakez Kayedab Excerpt from the article published in Progress in Neurobiology, Volume 214, July 2022, 102270, ISSN 0301-0082, DOI: https://doi.org/10.1016/j.pneurobio.2022.102270 Autors’ Highlights Co-occurring proteinopathies confound disease diagnosis and treatment development. Overlapping Aβ, tau, and α-Syn pathologies are observed in AD and related diseases. Aβ, tau, and α-Syn converge directly or indirectly […]
Continue ReadingSigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
By Zifen Xu, Yushuang Lei, Huan Qin, Shiyao Zhang, Ping Li, and Kai Yao Excerpt from the article published in International Journal of Molecular Sciences 23, no. 14: 7572. Published: 8 July 2022, DOI: https://doi.org/10.3390/ijms23147572 Editor’s Highlights The sigma-1 receptor is widely expressed in several organs, such as endocrine, immune, and reproductive tissues, the liver, kidney, […]
Continue ReadingSigma-1 receptor: A potential target for the development of antidepressants
By Yu-Ming Wang, Cong-Yuan Xi, Hong-Mei Jia, Jun He, Wen-Wen Lian, Yu Yan, Wen-Ping Wang, Wei-Ku Zhang, and Jie-Kun Xua Introduction to the article in Neurochemistry International, 8 July 2022, 105390, DOI: https://doi.org/10.1016/j.neuint.2022.105390 Autor’s Highlights The expression of Sigma-1 receptor is changed in animal models of depression and patients with depression. Activation of Sigma-1 receptor […]
Continue ReadingAlzheimer’s disease: Ablating single master site abolishes tau hyperphosphorylation
By Kristie Stefanoska, Mehul Gajwani, Amanda R. P. Tan, Holly I. Ahel, Prita R. Asih, Alexander Volkerling, Anne Poljak, and Arne Ittner Excerpt from the article published in SCIENCE ADVANCES, 6 Jul 2022, Vol 8, Issue 27DOI: 10.1126/sciadv.abl8809 Editor’s Highlights Alzheimer’s disease (AD) is characterized by extracellular β-amyloid (Aβ) plaques and the intraneuronal accumulation of […]
Continue ReadingTNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis
By Eun-Jin Bae, Minsun Choi, Jeong Tae Kim, Dong-Kyu Kim, Min Kyo Jung, Changyoun Kim, Tae-Kyung Kim, Jun Sung Lee, Byung Chul Jung, Soo Jean Shin, Ka Hyun Rhee, and Seung-Jae Lee Excerpt from the article published in Experimental & Molecular Medicine (2022)(2022), Published: 05 July 2022, DOI: https://doi.org/10.1038/s12276-022-00789-x Editor’s Highligths Parkinson’s disease (PD), is […]
Continue Reading