Sigma and Cardiovascular Diseases

Published research to date related to Sigma proteins and Cardiovascular diseases (CVD) has been conducted with compounds not developed by Advantx Pharmaceuticals Inc. Our therapeutic candidate ADV127 for Cardiovascular Diseases is the first truly selective, pharmaceutical-grade compound in development targeting the Sigma-1 receptor with a clean molecule and unambiguous agonist activity, far superior in potency, selectivity, safety, and efficacy to all others tested to date.

RECENT SCIENTIFIC PUBLICATIONS RELATED TO SIGMA RECEPTORS AND CARDIOVASCULAR DISEASES

Multi-Omics Analysis Reveals the Role of Sigma-1 Receptor in a Takotsubo-like Cardiomyopathy Model

By Yi Liu, Qing Chen, Jian-Zheng Yang, Xiu-Wen Li, Li-Jian Chen, Kai-Kai Zhang, Jia-Li Liu, Jia-Hao Li, Clare Hsu, Long Chen, Jia-Hao Zeng, Qi Wang, Dong Zhao, and Jing-Tao Xu Excerpt from the article published in Biomedicines. 12 October 2023; 11(10):2766. DOI: https://doi.org/10.3390/biomedicines11102766 Editor’s Highlights Abstract Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy that presents […]

The Neuroprotective Effect of Activation of Sigma-1 Receptor on Neural Injury by Optic Nerve Crush

By Yao Chen; Xueli Yang; and Junfeng Mao Excerpt from the article published in Investigative Ophthalmology & Visual Science September 2023, Vol.64, 9. Doi:https://doi.org/10.1167/iovs.64.12.9 Editor’s Highlights Abstract Purpose: This study aimed to explore the neuroprotective effects of sigma-1 receptor (S1R) on optic nerve crush (ONC) mice by upregulating its expression through intravitreal injection of adeno-associated virus (AAV). […]

Sigma-1 receptor knockout disturbs gut microbiota, remodels serum metabolome, and exacerbates isoprenaline-induced heart failure

By Jian-Zheng Yang, Kai-Kai Zhang, Hong-Wu Shen, Yi Liu, Xiu-Wen Li, Li-Jian Chen, Jia-Li Liu, Jia-Hao Li, Dong Zhao, Qi Wang, and Chu-Song Zhou Excerpt from the article published in Frontiers Microbiology, 31 August 2023, Sec. Microorganisms in Vertebrate Digestive Systems, Volume 14 – 2023, DOI: https://doi.org/10.3389/fmicb.2023.1255971 Editor’s Highlights Abstract Introduction: Heart failure (HF) is usually the […]

Sigma 1 receptor activation improves retinal structure and function in the RhoP23H/+ mouse model of autosomal dominant retinitis pigmentosa

By Shannon R. Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, and Sylvia B. Smith Extract from the article published in Experimental Eye Research, Volume 230, May 2023, 109462, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2023.109462 Editor’s Highlights Abstract Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to visual impairment and oftentimes complete blindness. Currently no […]

Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels

By Remex Naznin Sultana, Abdullah Chowdhury S., Aishwarya Richa, Nitu Sadia S., Traylor James, Hartman Brandon, King Judy, Bhuiyan Mohammad Alfrad Nobel, Kevil Christopher G., Orr A. Wayne, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 14, 27 March 2023Sec. Respiratory Physiology and Pathophysiology, ISSN 1664-042X, DOI: 10.3389/fphys.2023.1118770 Editor’s […]

Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

By Alba Vera-Zambrano, Maria Baena-Nuevo, Susanne Rinné, Marta Villegas-Esguevillas, Bianca Barreira, Gokcen Telli, Angela de Benito-Bueno, José Antonio Blázquez, Belén Climent, Francisco Pérez-Vizcaino, Carmen Valenzuela, Niels Decher, Teresa Gonzalez, and Angel Cogolludo Excerpt from the article published in Pharmacological Research, Volume 189, March 2023, 106684,ISSN 1043-6618, DOI: https://doi.org/10.1016/j.phrs.2023.106684. Editor’s Highlights Abstract KV1.5 channels are key […]

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes

By Jiang-Hui Wang, Daniel Urrutia-Cabrera, Jarmon G. Lees, Santiago Mesa Mora, Tu Nguyen, Sandy S. C. Hung, Alex W. Hewitt, Shiang Y. Lim, Thomas L. Edwards, and Raymond C. B. Wong Excerpt from the article published in the International Journal of Molecular Sciences. 8 February 2023; 24(4):3417. DOI: https://doi.org/10.3390/ijms24043417 Editor’s Highlights Abstract Age-related macular degeneration […]

Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases

By Francisco Javier Munguia-Galaviz, Alejandra Guillermina Miranda-Diaz, Miguel Alejandro Cardenas-Sosa, and Raquel Echavarria Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1997. DOI: https://doi.org/10.3390/ijms24031997 Editor’s Hihghlights Abstract Cardiovascular and renal diseases are among the leading causes of death worldwide, and regardless of current efforts, there is a demanding […]

Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus

By Wenjing Song, Yang Yao, Heling Zhang, Xin Hao, Liping Zhou, Zhixiao Song, Tiantian Wei, Tianyan Chi, Peng Liu, Xuefei Ji, and Libo Zou Excerpt from the article published in Molecules 2023, 28(1), 390; 2 January 2023; DOI: https://doi.org/10.3390/molecules28010390 Editor’s Highlights Abstract Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in […]

Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke

By Gufang Zhang, Qi Li, Weijie Tao, Pingping Qin, Jiali Chen, Huicui Yang, Jiaojiao Chen, Hua Liu, Qijun Dai, and Xuechu Zhen Excerpt from the article published in Theranostics. 2023 Jan 1;13(2):543-559. DOI: 10.7150/thno.77088. PMID: 36632219; PMCID: PMC9830433. Editor’s Highlights Abstract Background: Efferocytosis of apoptotic neurons by macrophages is essential for the resolution of inflammation and […]

Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes

By Hideaki Tagashira, Md. Shenuarin Bhuiyan, Yasuharu Shinoda, Ichiro Kawahata, Tomohiro Numata, and Kohji Fukunaga Introduction to the article published in Journal of Pharmacological Sciences, December 10, 2022, ISSN 1347-8613, DOI: https://doi.org/10.1016/j.jphs.2022.12.005. Editor’s Highlights Abstract The Sigma-1 receptor (Sigmar1) is downregulated in heart failure model mice with mitochondrial dysfunction. However, the mechanism in detail has […]

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation

By Timur A. Mavlyutov, Jing Li, Xinying Liu, Hongtao Shen, Huan Yang, Christopher R. McCurdy, Bikash Pattnaik, and Lian-Wang Guo Excerpt from the article published in Genes 13(12):2386, 16 December 2022, DOI: https://doi.org/10.3390/genes13122386 Editor’s Highlights Abstract The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding […]

σ2R/TMEM97 in retinal ganglion cell degeneration

By Hua Wang, Zhiyou Peng, Yiwen Li, James J. Sahn, Timothy R. Hodges, Tsung-Han Chou, Qiong Liu, Xuezhi Zhou, Shuliang Jiao, Vittorio Porciatti, Daniel J. Liebl, Stephen F. Martin, and Rong Wen Excerpt from the article published in Scientific Reports 12, 20753, 01 December 2022, DOI: https://doi.org/10.1038/s41598-022-24537-3 Editor’s Highlights Abstract The sigma 2 receptor (σ2R) […]

Sigma-1 receptor agonist, (+)-pentazocine, is neuroprotective in a Brown Norway rat microbead model of glaucoma

By Barbara A. Mysona, Jing Zhao, Oceane De Greef, August Beisel, Parth A. Patel, Lindsay Berman, Sylvia B. Smith, and Kathryn Bollinger Excerpt from the article published in Experimental Eye Research,  15 November 2022, 109308, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2022.109308. Abstract Purpose: Glaucoma is a worldwide leading cause of irreversible blindness. Standard treatments lower intraocular pressure […]

The Role of the Sigma-2 Receptor in Myocardial Ischemia-Reperfusion Injury

By Radhika Rastogi, Jing Li, Katherine Marsh, Aimee Zhang, Lian-Wang Guo, and Zequan Yang Abstract published in ACUTE CORONARY SYNDROMES, SESSION TITLE: VULNERABILITY AND CONSEQUENCE IN ACS, 30 Oct 2022 Circulation. 2022;146:A14321 Abstract Introduction: Pharmacological studies have identified two subtypes of sigma receptors, which are now known to be encoded by different genes. Activation of the […]

Mitochondria-Associated Endoplasmic Reticulum Membranes: Inextricably Linked with Autophagy Process

By Chonghao Ji, Zhanwei Zhang, Zechuan Li, Xiao She, Xiaoya Wang, Binyang Li, Xin Xu, Dawei Song, and Dongjiao Zhang Excerpt from the article published in Oxidative Medicine and Cellular Longevity (Hindawi), Volume 2022, 23 Aug 2022, Article ID 7086807, DOI: https://doi.org/10.1155/2022/7086807 Editor’s Highlights There is a growing body of evidence indicating Mitochondria-associated membranes (MAMs) act as […]

Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

By Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu, and Bo Yang Excerpt from the article published in Molecular Medicine volume 28, Article number: 87, 03 August 2022, DOI: https://doi.org/10.1186/s10020-022-00517-1 Editor’s Highlights With the increase of global aging population, the incidence of Heart Failure (HF) has increased […]

Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms

By Zifen Xu, Yushuang Lei, Huan Qin, Shiyao Zhang, Ping Li, and Kai Yao Excerpt from the article published in International Journal of Molecular Sciences 23, no. 14: 7572. Published: 8 July 2022, DOI: https://doi.org/10.3390/ijms23147572 Editor’s Highlights The sigma-1 receptor is widely expressed in several organs, such as endocrine, immune, and reproductive tissues, the liver, kidney, […]

(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration

By Manjuan Peng, Xuezhi Zhou, Fei Yao, Haibo Li, Weitao Song, Siqi Xiong, and Xiaobo Xia Excerpt from the article published in Frontiers in Medicine, volume 9, 27 June 2022, DOI: https://doi.org/10.3389/fmed.2022.879901 Editor’s Highlights Dry age-related macular degeneration (AMD) accounts for approximately 5.8% of legal blindness globally and is the leading cause of severe vision […]

Crosstalk of Astrocytes and Other Cells during Ischemic Stroke

By Tingting He, Guo-Yuan Yang, and Zhijun Zhang Excerpt from the article published in Life 2022, 12, 910. https://doi.org/10.3390/life12060910 Editor’s Highlights Astrocytes are the most abundant glial cell type; they play a major role in maintaining homeostasis. After brain ischemia, astrocytes changed from the normally bushy form to a hypertrophic stellate shape and then to a highly […]

Compositions and Functions of Mitochondria-Associated Endoplasmic Reticulum Membranes and Their Contribution to Cardioprotection by Exercise Preconditioning

By Yuhu Lv, Lin Cheng and Fenglin Peng Excerpt from the article published in Frontiers in Physiology, volume 13, 06 June 2022 DOI=10.3389/fphys.2022.910452 Editor’s Highlights Abstract Mitochondria-associated endoplasmic reticulum membranes (MAMs) are important components of intracellular signaling and contribute to the regulation of intracellular Ca2+/lipid homeostasis, mitochondrial dynamics, autophagy/mitophagy, apoptosis, and inflammation. Multiple studies have […]

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases

By Yiran E. Li, James R. Sowers, Claudio Hetz, and Jun Ren Excerpt from the article published in Cell Death Dis 13, 504 (2022). https://doi.org/10.1038/s41419-022-04942-2 Editor’s Highlights Mutually coupled membrane components between mitochondria and ER, referred to as mitochondria-associated membranes (MAMs). MAMs refer to the complex of outer mitochondrial membrane (OMM) and ER segregated by a distance […]

Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

By Zonghan Liu, Yi Sun, Zhengtang Qi, Lu Cao, and Shuzhe Ding Excerpt from the article published in Cell and Bioscience 12, 66 (2022). Published: 19 May 2022, DOI: https://doi.org/10.1186/s13578-022-00805-7 Editor’s Highlights Mitochondria are semiautonomous, semiself-replicating, highly dynamic organelles, endowed with their own circular, double-stranded DNA molecule that spans 16.6 kb and intramitochondrial replication and translational machinery. Intercellular mitochondrial […]

Neuroimmune cardiovascular interfaces control atherosclerosis

By Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, […]

Sigma-1 Receptor Agonists are Protective in Renal Ischemia/Reperfusion Injury

By Akos Roland Toth, Tamas Lakat, Judit Hodrea, Dora B Balogh, Adam Vannay, Laszlo Wagner, Attila Szabo, Andrea Fekete, and Adam Hosszu Excerpt from the article published in Nephrology Dialysis Transplantation, Volume 37, Issue Supplement_3, May 2022, gfac067.081, https://doi.org/10.1093/ndt/gfac067.081 Editor’s Highlights Sigma-1 receptor agonists act directly on proximal tubular cells by activating the S1R-Akt-eNOS signaling pathway […]

Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension

By Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang & Bo Yang (2022)   Excerpt from the article published in Bioengineered, 13:4, 10843-10856, DOI: 10.1080/21655979.2022.2065953 Editor’s Highlights Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive elevation in mean pulmonary artery pressure, which […]

Effects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats

By Sándor Váczi, Lilla Barna, Krisztián Laczi, Ferenc Tömösi, Gábor Rákhely, Botond Penke, Lívia Fülöp, Ferenc Bogár, Tamás Janáky, Mária A. Deli, and Zsófia Mezei Excerpt from the article published in European Journal of Pharmacology, 2022, 174983 Doi: https://doi.org/10.1016/j.ejphar.2022.174983. Editor’s Highlights Only a fraction of all cardiovascular diseases is of cardiac origin, and macro-and microvascular […]

Activation of Sigma-1 Receptor Alleviates ER-Associated Cell Death and Microglia Activation in Traumatically Injured Mice

By Mingming Shi, Liang Liu, Xiaobin Min, Liang Mi, Yan Chai, Fanglian Chen, Jianhao Wang, Shuyuan Yue, Jianning Zhang, Quanjun Deng, and Xin Chen Excerpt from the article published in Journal of Clinical Medicine 2022, 11, 2348 Doi: https://doi.org/10.3390/jcm11092348 Editor’s Highlights The sigma-1 receptor (Sig-1R) is a  ubiquitous ER-resident chaperone localized acting as a dynamic pluripotent […]

Sigma 2 receptor (σ2R/TMEM97) in Retinal Ganglion Cell Degeneration

By Hua Wang, Zhiyou Peng, Yiwen Li et al. Excerpt from the article published in Retinal Ganglion Cell Degeneration, 15 March 2022, PREPRINT (Version 1) available at Research Square Doi: https://doi.org/10.21203/rs.3.rs-1439890/v1 Editor’s Highlights The sigma 2 receptor (σ2R) plays a signicant role in the retinal ganglion cell (RGC) degeneration pathway and that inhibiting σ2R/TMEM97 function is […]

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection

By Jing Zhao; Graydon B. Gonsalvez; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger Excerpt from the article published in Investigative Ophthalmology & Visual Science February 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.2.1 Editor’s Highlights Abstract Purpose: Sigma 1 receptor (S1R) is expressed in retinal ganglion cells (RGCs) and astrocytes, and its activation is neuroprotective. We evaluated the contribution of S1R within optic […]

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

by Song, L., Bekdash, R., Morikawa, K. et al. Excerpt from the article published in Nat Cardiovasc Res 1, 142–156 (2022). https://doi.org/10.1038/s44161-021-00016-2 Editor’s Highlights Mutations in the CACNA1C gene, encoding the α2δ-1 subunit in the calcium channel CaV1.2, cause a life-threatening form of long QT syndrome (LQTS) named Timothy syndrome. SIGMA-1 receptor could be a therapeutic target for TS and […]

Sigma–1 receptor activation alleviates blood–brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF–GFRα1–RET pathway

By Danyang Liu, Luxi Yang, Peng Liu, Xuefei Ji, Xiaoxiao Qi, Ziqi Wang, Tianyan Chi, and Libo Zou Excerpt from the article published in Experimental Neurology, Volume 347, 2022, DOI: https://doi.org/10.1016/j.expneurol.2021.113867. Editors’ Highlights Sigma-1 receptor agonists could play an effective therapeutic role in preventing BBB damage in ischemic stroke and other cardiovascular conditions. Autors’ Highlights Sigma […]

The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes

by Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Naznin Sultana Remex, Mahboob Morshed, Sadia Nitu, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, James Traylor, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan Excerpt from the article published in Mitochondrion, Volume 62, 2022, Pages 159-175, ISSN 1567-7249, https://doi.org/10.1016/j.mito.2021.12.002. Editor’s Highlights […]

Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury

By Shi Mingming, Chen Fanglian, Chen Zhijuan, Yang Weidong, Yue Shuyuan, Zhang Jianning, and Chen Xin Excerpt from the article published in Frontiers in Cellular Neuroscience, 2021. DOI:10.3389/fncel.2021.685201 Editor’s Highlights Abstract The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a dynamic […]

Sigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma

By Linya Li, Shaoqing He, Yang Liu, Thomas Yorio, Dorette Z. Ellis Excerpt from the article published in Investigative Ophthalmology & Visual Science August 2021, Vol.62, 17. doi: https://doi.org/10.1167/iovs.62.10.17 Editor’s Highlights Degeneration of the retinal ganglion cells (RGCs), their axons, and optic nerves (ONs) are hallmarks in glaucoma.  The Sigma-1R (σ-1r) is localized at the endoplasmic […]

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

By Aishwarya Richa, Abdullah Chowdhury S., Morshed Mahboob, Remex Naznin Sultana, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 12, 2021. DOI: https://doi.org/10.3389/fphys.2021.705575 Editor’s Highlights Sigma-1 receptor is a multifunctional, ubiquitously expressed chaperone protein encoded by the SIGMAR1 gene. Alterations in Sigmar1’s subcellular localization, expression, and signaling have been […]

Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging

By Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa, Seigo Kinuya Excerpt from the article published in Circulation Journal, Article ID CJ-21-0320,  Online ISSN 1347-4820, Print ISSN 1346-9843, DOI: https://doi.org/10.1253/circj.CJ-21-0320 Editor’s Highlights The sigma-1 receptor chaperone (σ1R) is considered as a pluripotent modulator with resultant multiple functional manifestations in […]

Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment

By Jing Qu, Miaoling Li, Dongxu Li, Yanguo Xin, Junli Li, Song Lei, Wenchao Wu, and Xiaojing Liu Excerpt from the article published in Oxidative medicine and cellular longevity vol. 2021 8836818. 4 Jan. 2021, DOI:10.1155/2021/8836818 Editor’s Highlights Cardiac fibrosis is a common pathological process in the development of various cardiovascular diseases and the risk for […]

Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics

By Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Mohammad Alfrad Nobel Bhuiyan, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Hanna Osinska, Jeffrey Robbins, John N. Lorenz, and Md. Shenuarin Bhuiyan Excerpt from the article published in Journal of the American Heart Association. 2018;7:e009775, 11 Oct 2018, DOI: https://doi.org/10.1161/JAHA.118.009775 Editor’s Highlights […]

Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction

By Giuseppina Amodio, Ornella Moltedo, Raffaella Faraonio, and Paolo Remondelli Excerpt from the article published in Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 4946289, 13 pages, 14 Mar 2018. DOI: https://doi.org/10.1155/2018/4946289 Editor’s Highlights Abstract In endothelial cells, the tight control of the redox environment is essential for the maintenance of vascular homeostasis. The […]

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

By Jing Zhao, Barbara A. Mysona, Jing Wang, Graydon B. Gonsalvez, Sylvia B. Smith, and Kathryn E. Bollinger Excerpt from the article published in PLOS ONE,  September 12, 2017, DOI: https://doi.org/10.1371/journal.pone.0184421 Editor’s Highlights Neuronal and glial cell types throughout the retina and optic nerve contain sigma 1 receptor (S1R), and its agonists display robust neuroprotective […]

Transit and integration of extracellular mitochondria in human heart cells

By Douglas B. Cowan, Rouan Yao, Jerusha K. Thedsanamoorthy, David Zurakowski, Pedro J. del Nido, and James D. McCully Excerpt from the article published in Scientific Reports 7, 17450 (2017). Published: 12 December 2017, DOI: https://doi.org/10.1038/s41598-017-17813-0 Editor’s Highlights Mitochondria play an essential role in energy production and cellular homeostasis. Dysfunction of these organelles as a result of ischemia […]

Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis

By Jennifer A. Felsted, Cheng-Hao Chien, Dongqing Wang, Micaella Panessiti, Dominique Ameroso, Andrew Greenberg, Guoping Feng, Dong Kong, and Maribel Rios Excerpt from the article published in Cell Reports, volume 21, issue 10, P2737-2747, December 2017, DOI: https://doi.org/10.1016/j.celrep.2017.11.048 Editor’s Highlights Alpha2delta-1 (α2δ-1) plays a chief role in energy and glucose balance control acting downstream of brain-derived neurotrophic […]