Sigma 1 receptor - Advantx Pharmaceuticals Inc.

The Neuroprotective Effect of Activation of Sigma-1 Receptor on Neural Injury by Optic Nerve Crush

By Yao Chen; Xueli Yang; and Junfeng Mao Excerpt from the article published in Investigative Ophthalmology & Visual Science September 2023, Vol.64, 9. Doi:https://doi.org/10.1167/iovs.64.12.9 Editor’s Highlights Abstract Purpose: This study aimed to explore the neuroprotective effects of sigma-1 receptor (S1R) on optic nerve crush (ONC) mice by upregulating its expression through intravitreal injection of adeno-associated virus (AAV). […]

Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury

By Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, and Anand Veeravagu Excerpt from the article published in Scientific Reports 13, 14762 (07 September 2023). DOI: https://doi.org/10.1038/s41598-023-42063-8 Editor’s Highlights Abstract Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been […]

Sigma-1 receptor knockout disturbs gut microbiota, remodels serum metabolome, and exacerbates isoprenaline-induced heart failure

By Jian-Zheng Yang, Kai-Kai Zhang, Hong-Wu Shen, Yi Liu, Xiu-Wen Li, Li-Jian Chen, Jia-Li Liu, Jia-Hao Li, Dong Zhao, Qi Wang, and Chu-Song Zhou Excerpt from the article published in Frontiers Microbiology, 31 August 2023, Sec. Microorganisms in Vertebrate Digestive Systems, Volume 14 – 2023, DOI: https://doi.org/10.3389/fmicb.2023.1255971 Editor’s Highlights Abstract Introduction: Heart failure (HF) is usually the […]

Structure-Based Modeling of Sigma 1 Receptor Interactions with Ligands and Cholesterol and Implications for Its Biological Function

By Meewhi Kim and Ilya Bezprozvanny Excerpt from the article published in International Journal of Molecular Sciences 24, no. 16: 12980. 19 August 2023, DOI: https://doi.org/10.3390/ijms241612980 Abstract The sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. The S1R plays an important role in neuronal health and it is an established therapeutic target […]

The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants

By Adam Hosszu, Akos R. Toth, Tamas Lakat, Ganna Stepanova, Zsuzsanna Antal, Laszlo J. Wagner, Attila J. Szabo, and Andrea Fekete Excerpt from the article published in International Journal of Molecular Sciences. 19 July 2023; 24(14):11630. https://doi.org/10.3390/ijms241411630 Editor’s highlights Abstract Kidney transplantation is the preferred treatment for patients with end-stage kidney disease. Maintaining organ viability […]

An Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer

By Taylor S. Robinson and Mahasin A. Osman Excerpt from the article published in Cancers, 2 July 2023, 15, 3464. DOI: https://doi.org/10.3390/cancers15133464 Editor’s Highlights Simple Summary Breast cancer continues to be the number one cause of cancer mortality among women. Because breast cancer is a heterogenous disease there is a need for a more personalized approach to […]

Novel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer’s, Huntington’s, and stroke: Aging as a consequence of glycolysis

By Rachel Litke, Kun-Hyung Roh, Yonejung Yoon, Sindhu Vangeti, Irene Ramos-lopez, Husnu Kaniskan, Jian Jin, Christopher Kellner, and Charles Mobbs Excerpt from the article published in bioRxiv 2023.06.12, 544352; doi: https://doi.org/10.1101/2023.06.12.544352 Editor’s Highlights Abstract Alzheimer’s Disease (AD) and other age-related diseases are increasingly among the most devastating strains on public health systems as the population ages, yet […]

Defining the ligand-dependent proximatome of the sigma 1 receptor

By Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, and Kathryn E. Bollinger Excerpt from the article published in Frontiers in Cell and Developmental Biology, 11, 07 June 2023Sec. Membrane Traffic, DOI: 1045759.https://doi.org/10.3389/fcell.2023.1045759 Editor’s Highlights Abstract Sigma 1 Receptor (S1R) is a therapeutic target for a […]

Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson’s Disease

By Talha Siddiqui and Lokesh Kumar Bhatt Excerpt from the article published in Neurochem Research. 31 May 2023. DOI: https://doi.org/10.1007/s11064-023-03960-6 Editor’s Highlights Abstract Parkinson’s disease is a neurodegenerative disease affecting mainly the elderly population. It is characterized by the loss of dopaminergic neurons of the substantia nigra pars compacta region. Parkinson’s disease patients exhibit motor […]

Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin

By Feng Zhao, Tianli Yang, Liuhua Zhou, Rongfei Li, Jingyu Liu, Jun Zhao, and Ruipeng Jia Excerpt from the article published in Aging (Albany NY). 2023 May 16; DOI: https://doi.org/10.18632/aging.204721 Editor’s Highlights Abstract The extracellular matrix (ECM) regulates many biological functions involved in tumorigenesis and tumor development; however, the underlying mechanism remains unknown. Sigma 1 […]

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