Tag Archives: Sigma 1 receptor

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

By Shang-Yi A. Tsai, Michael J. Pokrass, Neal R. Klauer, Hiroshi Nohara, and Tsung-Ping Su Excerpt from the article published in PNAS May 11, 2015, 112(21) 6742-6747 DOI: https://doi.org/10.1073/pnas.1422001112 Editor’s Highlights Malfunction of axonal maintenance, regeneration, and target recognition contribute to CNS disorders such as Parkinson’s disease (PD). Cyclin-dependent kinase (Cdk5) is a ubiquitously expressed enzyme; […]

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway

By A. Hyrskyluoto, I. Pulli, K. Törnqvist, T. Huu Ho, L. Korhonen, and D. Lindholm Excerpt from the article published in Cell Death Dis 4, e646 (2013). https://doi.org/10.1038/cddis.2013.170 Editor’s Highlights Huntington’s disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder that is caused by an expansion of cytosine–adenine–guanine (CAG) repeats in the first exon of the huntingtin […]