Sigma 1 receptor - Advantx Pharmaceuticals Inc.

Regulation of membrane NMDA receptors by dynamics and protein interactions

By Mar Petit-Pedrol and Laurent Groc Excerpt from the article published in Journal of Cell Biology 4 January 2021; 220 (1): e202006101. doi: https://doi.org/10.1083/jcb.202006101 Editor’s Highlights The N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors whose activation and calcium permeability play central roles in glutamate synapse physiology. NMDARs form protein–protein interactions with several transmembrane neurotransmitter receptors and ion channels […]

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

By Sánchez-Blázquez, P., Cortés-Montero, E., Rodríguez-Muñoz, M. et al. Excerpt from the article published in Mol Brain 13, 150 (2020). https://doi.org/10.1186/s13041-020-00676-4 Editor’s Highlights σ2R is essential for the antinociceptive effects of exogenous and endogenous ligands of MOR but not for the antinociceptive effects of other families of G-receptors that also mediate analgesia, such as DOR, CB1R and α2AR. […]

Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models

By Pin-Tse Lee, Jean-Charles Liévens, Shao-Ming Wang, Jian-Ying Chuang, Bilal Khalil, Hsiang-en Wu, Wen-Chang Chang, Tangui Maurice, and Tsung-Ping Su Excerpt from the article published in Nature Communications 11, 5580 (2020). https://doi.org/10.1038/s41467-020-19396-3 Editor’s Highlights Amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD), either sporadic or familial, share a (G4C2)-RNA hexanucleotide repeat expansion (HRE) upstream of […]

Chaperone Sigma1R and Antidepressant Effect

By Mikhail V. Voronin, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 2020 Oct; 21(19): 7088. Published 2020 Sep 25. DOI: 10.3390/ijms21197088 Editor’s Highlights Antidepressant use is accompanied by various side effects, and about one-third of patients do not achieve remission. Sigma-1 receptor (Sigma1R) acts as a chaperone to stabilize […]

Sigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts

By Huan Yang, Hongtao Shen, Jing Li, Kristin I. Stanford, and Lian-Wang Guo Excerpt from the article published in Cell Signal. 2020 Nov;75:109732. DOI: 10.1016/j.cellsig.2020.109732. Epub 2020 Aug 2. PMID: 32750415; PMCID: PMC7530065. Editor’s Highlights Abstract The sigma-1 receptor (Sig1R) is a unique ligand-operated endoplasmic reticulum (ER) protein without any mammalian homolog. It has long […]

Distinct Regulation of σ1 Receptor Multimerization by Its Agonists and Antagonists in Transfected Cells and Rat Liver Membranes

By Weimin Conrad Hong Excerpt from the article published in Journal of Pharmacology and Experimental Therapeutics, May 2020, 373 (2) 290-301; DOI: https://doi.org/10.1124/jpet.119.262790 Editor’s Highlights The sigma-1 receptor (σ1R) interacts with and modulates the activity of a plethora of partner proteins, including channels, receptors, and transporters, and regulates their function. Changes in σ1R oligomerization by ligands can modulate the availability of σ1R […]

Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells

By Tao Bai, Pengxu Lei, Hao Zhou, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Lin Zhou, and Yuling Sun Excerpt from the article published in Journal of Cellular and Molecular Medicine 2019 Nov; 23(11): 7349–7359. DOI: 10.1111/jcmm.14594 Editor’s Highlights Hepatocellular carcinoma (HCC) is a common type of cancer that is ranked sixth in prevalence and third in mortality worldwide. […]

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

by Daniel A. Ryskamp, Svetlana Korba, Vladimir Zhemkov, Nina Kraskovskaya, and Ilya Bezprozvanny Excerpt from the article published in Front. Neurosci., 28 August 2019 | https://doi.org/10.3389/fnins.2019.00862 Editor’s Highlights Abstract Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in endoplasmic reticulum (ER) membranes and changes in its function and/or expression have been associated with various neurological disorders including amyotrophic lateral sclerosis/frontotemporal dementia, […]

Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain

By Mireia Carcolé, Sami Kummer, Leonor Gonçalves, Daniel Zamanillo, Manuel Merlos, Anthony H. Dickenson, Begoña Fernández-Pastor, David Cabañero, and Rafael Maldonado Excerpt from the article published in British Journal of Pharmacology, 23 July 2019; 176: 3939– 3955. DOI: https://doi.org/10.1111/bph.14794 Abstract Background and Purpose: Osteoarthritic pain is a chronic disabling condition lacking effective treatment. Continuous use of opioid drugs during […]

The Sigma-1 Receptor in Cellular Stress Signaling

By Teruo Hayashi Excerpt from the article published in Frontiers in Neuroscience, 16 July 2019 | https://doi.org/10.3389/fnins.2019.00733 Editor’s Highlights The sigma-1 receptor (Sig-1R)’s structure, is an integral endoplasmic reticulum (ER) membrane protein which shares no homology with any other mammalian protein. Sig-1R is enriched in a specialized ER subdomain which physically contacts the mitochondria, called the […]

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