Sigma 1 receptor - Advantx Pharmaceuticals Inc.

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

By Aishwarya Richa, Abdullah Chowdhury S., Morshed Mahboob, Remex Naznin Sultana, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 12, 2021. DOI: https://doi.org/10.3389/fphys.2021.705575 Editor’s Highlights Sigma-1 receptor is a multifunctional, ubiquitously expressed chaperone protein encoded by the SIGMAR1 gene. Alterations in Sigmar1’s subcellular localization, expression, and signaling have been […]

Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging

By Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa, Seigo Kinuya Excerpt from the article published in Circulation Journal, Article ID CJ-21-0320, Online ISSN 1347-4820, Print ISSN 1346-9843, DOI: https://doi.org/10.1253/circj.CJ-21-0320 Editor’s Highlights The sigma-1 receptor chaperone (σ1R) is considered as a pluripotent modulator with resultant multiple functional manifestations in […]

Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress

By Koshenov, Z.; Oflaz, F.E.; Hirtl, M.; Pilic, J.; Bachkoenig, O.A.; Gottschalk, B.; Madreiter-Sokolowski, C.T.; Rost, R.; Malli, R.; Graier, W.F. Excerpt from the article published in Metabolites 2021, 11, 422. Published: 26 June 2021, DOI: https://doi.org/10.3390/metabo11070422 Editor’s Highlights The endoplasmic reticulum (ER) is a complex, multifunctional organelle of eukaryotic cells and responsible for the trafficking and […]

The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation

By Dominique Fernández, Antonia Geisse, Jose Ignacio Bernales, Alonso Lira, and Fabiola Osorio Excerpt from the article published in Frontiers of Aging Neuroscience, 11 June 2021, Sec. Cellular and Molecular Mechanisms of Brain-aging, DOI: https://doi.org/10.3389/fnagi.2021.682633 Editor’s Highlights Cells possess regulatory mechanisms that maintain proteostasis in conditions that overload the folding capacity of the organelle (a […]

The Role of Astrocytes in the Neurorepair Process

By Raphaela Almeida Chiareli, Gustavo Almeida Carvalho, Bruno Lemes Marques, Lennia Soares Mota, Onésia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Alexander Birbrair, Renato Santiago Gomez, Fabrício Simão, Friederike Klempin, Marcel Leist, and Mauro Cunha Xavier Pinto Excerpt from the article published in Frontiers in Cell and Developmental Biology, 25 May 2021 | https://doi.org/10.3389/fcell.2021.665795 Editor’s Highlights Astrocytes […]

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

By Vladimir Zhemkov, Jonathon A Ditlev, Wan-Ru Lee, Mikaela Wilson, Jen Liou, Michael K Rosen, Ilya Bezprozvanny Excerpt from the article published in eLife 2021;10:e65192 DOI: 10.7554/eLife.65192 Editor’s Highlights Sigma-1 receptor (S1R) modulates many physiological processes, such as cell excitability, transcriptional activity, Ca2+ homeostasis, stress response, and autophagy. Many biological functions of the Sigma-1 receptor can be explained […]

Sigma-1 Receptor Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases

by Zhemkov V, Geva M, Hayden MR, Bezprozvanny I Excerpt from the article published in Int J Mol Sci. 2021;22(8):4082. Published 2021 Apr 15. https://doi.org/10.3390/ijms22084082 Editor’s Highlights The Sigma-1 receptor (S1R) is a well-established target for the treatment of neurodegenerative disorders, and it plays a key role in neurodegenerative diseases. Some variants of the S1R […]

Negative Impact of Sigma-1 Receptor Agonist Treatment on Tissue Integrity and Motor Function Following Spinal Cord Injury

By Alise Lattard, Gaëtan Poulen, Sylvain Bartolami, Yannick N. Gerber, and Florence E. Perrin Excerpt from the article published in Frontiers in Pharmacology, 10 February 2021Sec. Neuropharmacology, Volume 12 – 2021, DOI: https://doi.org/10.3389/fphar.2021.614949 Editors Highlights Abstract In traumatic spinal cord injury, the initial trauma is followed by a cascade of impairments, including excitotoxicity and calcium […]

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain

By Shao-Ming Wang, Nino Goguadze, Yuriko Kimura, Yuko Yasui, Bin Pan, Tzu-Yun Wang, Yoki Nakamura, Yu-Ting Lin, Quinn H. Hogan, Katherine L. Wilson, Tsung-Ping Su, and Hsiang-en Wu Excerpt from the article published in Molecular Neurobiology volume 58, pages 2523–2541 (2021) DOI: https://doi.org/10.1007/s12035-020-02276-8 Editor’s Highlights Neuropathic pain is one of the most debilitating forms of […]

Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment

By Jing Qu, Miaoling Li, Dongxu Li, Yanguo Xin, Junli Li, Song Lei, Wenchao Wu, and Xiaojing Liu Excerpt from the article published in Oxidative medicine and cellular longevity vol. 2021 8836818. 4 Jan. 2021, DOI:10.1155/2021/8836818 Editor’s Highlights Cardiac fibrosis is a common pathological process in the development of various cardiovascular diseases and the risk for […]

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