Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid
By Shang-Yi A. Tsai, Michael J. Pokrass, Neal R. Klauer, Hiroshi Nohara, and Tsung-Ping Su Excerpt from the article published in PNAS May 11, 2015, 112(21) 6742-6747 DOI: https://doi.org/10.1073/pnas.1422001112 Editor’s Highlights Malfunction of axonal maintenance, regeneration, and target recognition contribute to CNS disorders such as Parkinson’s disease (PD). Cyclin-dependent kinase (Cdk5) is a ubiquitously expressed enzyme; […]
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