Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases
By Urmi Senguptaab, and Rakez Kayedab Excerpt from the article published in Progress in Neurobiology, Volume 214, July 2022, 102270, ISSN 0301-0082, DOI: https://doi.org/10.1016/j.pneurobio.2022.102270 Autors’ Highlights Co-occurring proteinopathies confound disease diagnosis and treatment development. Overlapping Aβ, tau, and α-Syn pathologies are observed in AD and related diseases. Aβ, tau, and α-Syn converge directly or indirectly […]
Continue ReadingTNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis
By Eun-Jin Bae, Minsun Choi, Jeong Tae Kim, Dong-Kyu Kim, Min Kyo Jung, Changyoun Kim, Tae-Kyung Kim, Jun Sung Lee, Byung Chul Jung, Soo Jean Shin, Ka Hyun Rhee, and Seung-Jae Lee Excerpt from the article published in Experimental & Molecular Medicine (2022)(2022), Published: 05 July 2022, DOI: https://doi.org/10.1038/s12276-022-00789-x Editor’s Highligths Parkinson’s disease (PD), is […]
Continue ReadingNMDA and AMPA Receptors at Synapses: Novel Targets for Tau and α-Synuclein Proteinopathies
By Maria Italia, Elena Ferrari, Monica Diluca, and Fabrizio Gardoni Excerpt from the article published in Biomedicines 10, no. 7: 1550. Published: 29 June 2022 DOI: https://doi.org/10.3390/biomedicines10071550 Editor’s Highlights Aberrant levels, post-translational modifications (PTMs), mislocalization, and aggregation of tau and α-synuclein have been widely described in Alzheimer’s disease (AD) and related tauopathies and Parkinson’s disease (PD) […]
Continue ReadingMitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
By Zonghan Liu, Yi Sun, Zhengtang Qi, Lu Cao, and Shuzhe Ding Excerpt from the article published in Cell and Bioscience 12, 66 (2022). Published: 19 May 2022, DOI: https://doi.org/10.1186/s13578-022-00805-7 Editor’s Highlights Mitochondria are semiautonomous, semiself-replicating, highly dynamic organelles, endowed with their own circular, double-stranded DNA molecule that spans 16.6 kb and intramitochondrial replication and translational machinery. Intercellular mitochondrial […]
Continue ReadingSingle-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease
By Tushar Kamath, Abdulraouf Abdulraouf, S. J. Burris, Jonah Langlieb, Vahid Gazestani, Naeem M. Nadaf, Karol Balderrama, Charles Vanderburg, and Evan Z. Macosko Excerpt from the article published in Nature Neuroscience (2022). https://doi.org/10.1038/s41593-022-01061-1ce Editor’s Highlights A single subtype of dopamine (DA) neurons, marked by the expression of the gene AGTR1 and spatially confined to the ventral tier of the […]
Continue ReadingOrder through destruction: how ER-associated protein degradation contributes to organelle homeostasis
By John C Christianson and Pedro Carvalho Excerpt from the article published in The EMBO Journal (2022)41:e109845 DOI: https://doi.org/10.15252/embj.2021109845 Editor’s Highlights As a large, multifunctional organelle, the endoplasmic reticulum (ER) houses robust protein quality control systems, on which it relies heavily. The best-characterized protein quality control system of the ER is the ubiquitin-proteasome-dependent process of […]
Continue ReadingMetabolomics and biochemical alterations caused by pleiotrophin in the 6-hydroxydopamine mouse model of Parkinson’s disease
By Esther Gramage, Jorge Sáiz, Rosalía Fernández-Calle, Yasmina B. Martín, María Uribarri, Marcel Ferrer-Alcón, Coral Barbas, and Gonzalo Herradón Excerpt from the article published in Scientific Reports volume 12, Article number: 3577 (2022) DOI https://doi.org/10.1038/s41598-022-07419-6 Editor’s Highlights Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and […]
Continue ReadingNovel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands
By Ferenc Bogár, Lívia Fül. and Botond Penke Excerpt from the article published in Biomolecules 2022, 12, 363, Published: 25 February 2022, DOI: https://doi.org/10.3390/biom12030363 Editor’s Highlights Sigma-1 Receptor is a Central Regulator of Cell Survival As Sig-1R controls ER stress and the inflammatory processes in the cells, Sig-1R agonists have been tested in preclinical studies and […]
Continue ReadingMonitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
By Laura Torres-Garcia, Joana M. P. Domingues, Edoardo Brandi, Caroline Haikal, Janitha M. Mudannayake, Inês C. Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F. Outeiro, Gunnar K. Gouras, and Jia-Yi Li Excerpt from the article published in Scientific Reports volume 12, Article number: 2987 Published: 22 February 2022 DOI: https://doi.org/10.1038/s41598-022-06846-9 Editor’s Highlights α-synuclein (aSyn) is […]
Continue ReadingLewy body disease or diseases with Lewy bodies?
By Kateřina Menšíková, Radoslav Matěj, Carlo Colosimo, Raymond Rosales, Lucie Tučková, Jiří Ehrmann, Dominik Hraboš, Kristýna Kolaříková, Radek Vodička, Radek Vrtěl, Martin Procházka, Martin Nevrlý, Michaela Kaiserová, Sandra Kurčová, Pavel Otruba, and Petr Kaňovský Excerpt from the article published in npj Parkinson’s Disease volume 8, Article number: 3 (2022). Published: 10 January 2022 DOI: https://doi.org/10.1038/s41531-021-00273-9 […]
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