The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants
By Adam Hosszu, Akos R. Toth, Tamas Lakat, Ganna Stepanova, Zsuzsanna Antal, Laszlo J. Wagner, Attila J. Szabo, and Andrea Fekete Excerpt from the article published in International Journal of Molecular Sciences. 19 July 2023; 24(14):11630. https://doi.org/10.3390/ijms241411630 Editor’s highlights Abstract Kidney transplantation is the preferred treatment for patients with end-stage kidney disease. Maintaining organ viability […]
Continue ReadingAn Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer
By Taylor S. Robinson and Mahasin A. Osman Excerpt from the article published in Cancers, 2 July 2023, 15, 3464. DOI: https://doi.org/10.3390/cancers15133464 Editor’s Highlights Simple Summary Breast cancer continues to be the number one cause of cancer mortality among women. Because breast cancer is a heterogenous disease there is a need for a more personalized approach to […]
Continue ReadingNovel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer’s, Huntington’s, and stroke: Aging as a consequence of glycolysis
By Rachel Litke, Kun-Hyung Roh, Yonejung Yoon, Sindhu Vangeti, Irene Ramos-lopez, Husnu Kaniskan, Jian Jin, Christopher Kellner, and Charles Mobbs Excerpt from the article published in bioRxiv 2023.06.12, 544352; doi: https://doi.org/10.1101/2023.06.12.544352 Editor’s Highlights Abstract Alzheimer’s Disease (AD) and other age-related diseases are increasingly among the most devastating strains on public health systems as the population ages, yet […]
Continue ReadingDefining the ligand-dependent proximatome of the sigma 1 receptor
By Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, and Kathryn E. Bollinger Excerpt from the article published in Frontiers in Cell and Developmental Biology, 11, 07 June 2023Sec. Membrane Traffic, DOI: 1045759.https://doi.org/10.3389/fcell.2023.1045759 Editor’s Highlights Abstract Sigma 1 Receptor (S1R) is a therapeutic target for a […]
Continue ReadingBS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting
By Claudia Sorbi, Silvia Belluti, Claudio Giacinto Atene, Federica Marocchi, Pasquale Linciano, Neena Roy, Elia Paradiso, Livio Casarini, Simone Ronsisvalle, Tommaso Zanocco-Marani, Livio Brasili, Luisa Lanfrancone, Carol Imbriano, Giulia Di Rocco, and Silvia Franchini Excerpt from the article published in the International Journal of Molecular Sciences. 2 June 2023; 24(11):9684. DOI: https://doi.org/10.3390/ijms24119684 Editor’s Highlights Abstract […]
Continue ReadingTargeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson’s Disease
By Talha Siddiqui and Lokesh Kumar Bhatt Excerpt from the article published in Neurochem Research. 31 May 2023. DOI: https://doi.org/10.1007/s11064-023-03960-6 Editor’s Highlights Abstract Parkinson’s disease is a neurodegenerative disease affecting mainly the elderly population. It is characterized by the loss of dopaminergic neurons of the substantia nigra pars compacta region. Parkinson’s disease patients exhibit motor […]
Continue ReadingSig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin
By Feng Zhao, Tianli Yang, Liuhua Zhou, Rongfei Li, Jingyu Liu, Jun Zhao, and Ruipeng Jia Excerpt from the article published in Aging (Albany NY). 2023 May 16; DOI: https://doi.org/10.18632/aging.204721 Editor’s Highlights Abstract The extracellular matrix (ECM) regulates many biological functions involved in tumorigenesis and tumor development; however, the underlying mechanism remains unknown. Sigma 1 […]
Continue ReadingSynaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain
By Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M. Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I. McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian et al. Excerpt from the article published in Neuron, Elsevier, May 15, 2023, DOI: https://doi.org/10.1016/j.neuron.2023.04.020 Highlights Summary In Alzheimer’s […]
Continue ReadingTargeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
By Dicson S. Malar, Premrutai Thitilertdecha, Kanokphorn S. Ruckvongacheep, Sirikalaya Brimson, Tewin Tencomnao, and James M. Brimson Excerpt from the article published in CNS Drugs, May 2023. DOI: https://doi.org/10.1007/s40263-023-01007-6 Editor’s Highlights Abstract The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a genetically unrelated protein with […]
Continue ReadingAbundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains
By Andrew M. Stern,Yang Yang,Shanxue Jin,Keitaro Yamashita,Angela L. Meunier,Wen Liu,Yuqi Cai,Maria Ericsson,Lei Liu,Michel Goedert,Sjors H.W. Scheres, and Dennis J. Selkoe Excerpt from the article published in Neuron, May 10, 2023 DOI: https://doi.org/10.1016/j.neuron.2023.04.007 Highlights Summary Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in supernatants following ultracentrifugation of aqueous extracts from Alzheimer’s disease […]
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