Scientific Papers - Advantx Pharmaceuticals Inc.

Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice

By James J Sahn, Galo L Mejia, Pradipta R Ray, Stephen F Martin, and Theodore J Price Excerpt from the article published in ACS chemical neuroscience, 2017 Aug 16;8(8):1801-1811. DOI: https://doi.org/10.1021/acschemneuro.7b00200 Free PMC article Editor’s Highlights Abstract Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be […]

The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?

By Roberta Celli, Ines Santolini, Michela Guiducci, Gilles van Luijtelaar, Pasquale Parisi, Pasquale Striano, Roberto Gradini, Giuseppe Battaglia, Richard T. Ngomba, and Ferdinando Nicoletti Excerpt from the article published in Current Neuropharmacology 2017 Aug; 15(6): 918–925. Published online 2017 Aug. doi: 10.2174/1570159X15666170309105451 Editor’s Highlights Chilhood and juvenile absence epilepsy belongs to a group of epileptic syndromes of genetic origin […]

Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington’s Disease Mutation

By Kiersten Berggren, Sonal Agrawal, Julia A. Fox, Justin Hildenbrand, Ryan Nelson, Ashley I. Bush, and Jonathan H. Fox Excerpt from the Authors manuscript; available in PMC 2019 Jun 26. Published in final edited form as Journal of Huntington’s Disease, 2017; 115–125. doi: 10.3233/JHD-170242 Editor’s Highlights Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease caused by a […]

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer

By Jeffrey D. Thomas; Charles G. Longen; Halley M. Oyer; Nan Chen; Christina M. Maher; Joseph M. Salvino; Blase Kania; Kelsey N. Anderson; William F. Ostrander; Karen E. Knudsen; and Felix J. Kim Excerpt from the article published in Cancer Res (2017) 77 (9): 2439–2452. DOI: https://doi.org/10.1158/0008-5472.CAN-16-1055 Editor’s Highlights Androgen receptor (AR) is the primary driver […]

Nonlinear EEG biomarker profiles for autism and absence epilepsy

By William J. Bosl, Tobias Loddenkemper, and Charles A. Nelson Excerpt from the article published in Neuropsychiatr Electrophysiol 3, 1 (2017). https://doi.org/10.1186/s40810-017-0023-x Editor’s Highlights Autism spectrum disorder (ASD) and epilepsy are common neurodevelopmental disorders that account for a large proportion of child and adult neurologic burden of disease. Childhood absence epilepsy (AE) is a generalized epilepsy syndrome […]

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

By Maria Laura Pati, John R. Hornick, Mauro Niso, Francesco Berardi, Dirk Spitzer, Carmen Abate, and William Hawkins Excerpt of the article published in BMC Cancer 17, 51 (2017). https://doi.org/10.1186/s12885-016-3040-4 Editor’s Highlights Pancreatic cancer is the fourth leading cause of cancer-related mortalities with an overall five-year survival rate of only 7%. Sigma receptors subtypes, namely sigma-1 and […]

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer’s disease

By Bitna Yi, James J. Sahn, Pooneh Memar Ardestani, Andrew K. Evans, Luisa L. Scott, Jessica Z. Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan T. Pierce, Stephen F. Martin, and Mehrdad Shamloo Excerpt from the article published in Journal of Neurochemistry, 07 December 2016, 140: 561-575. DOI: https://doi.org/10.1111/jnc.13917 Editor’s Highlights Abstract Accumulating evidence suggests that […]

Aβ mediates Sigma receptor degradation via CaN/NFAT pathway

By Min Fang, Pei Zhang, Yanxin Zhao, Aiping Jin, and Xueyuan Liu Excerpt from the article published in American Journal of Translational Research 2016; 8(8): 3471–3481. Published online 2016 Aug 15. PMCID: PMC5009399 Editor’s Highlights Extracellular Aβ accumulation has been found as a major molecular mechanism underlying the pathogenesis of Alzheimer disease (AD). The abnormal Aβ accumulation may […]

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

By Shang-Yi A. Tsai, Michael J. Pokrass, Neal R. Klauer, Hiroshi Nohara, and Tsung-Ping Su Excerpt from the article published in PNAS May 11, 2015, 112(21) 6742-6747 DOI: https://doi.org/10.1073/pnas.1422001112 Editor’s Highlights Malfunction of axonal maintenance, regeneration, and target recognition contribute to CNS disorders such as Parkinson’s disease (PD). Cyclin-dependent kinase (Cdk5) is a ubiquitously expressed enzyme; […]

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway

By A. Hyrskyluoto, I. Pulli, K. Törnqvist, T. Huu Ho, L. Korhonen, and D. Lindholm Excerpt from the article published in Cell Death Dis 4, e646 (2013). https://doi.org/10.1038/cddis.2013.170 Editor’s Highlights Huntington’s disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder that is caused by an expansion of cytosine–adenine–guanine (CAG) repeats in the first exon of the huntingtin […]

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