Sigma 1 Receptor is Overexpressed in Hepatocellular Adenoma: Involvement of ERα and HNF1α
By Laure Villemain, Sylvie Prigent, Aurélie Abou-Lovergne, Laura Pelletier, Magali Chiral, Marco Pontoglio, Fabienne Foufelle, Stefano Caruso, Raphael Pineau, Sandra Rebouissou, Eric Chevet, Jessica Zucman-Rossi, and Laurent Combettes Excerpt from the article published in Cancers (Special Issue Therapeutic Targeting of the Unfolded Protein Response in Cancer) 2020; 12(8):2213. https://doi.org/10.3390/cancers12082213 Editor’s Highlights Hepatocellular adenomas (HCAs) are rare […]
Continue ReadingSigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts
By Huan Yang, Hongtao Shen, Jing Li, Kristin I. Stanford, and Lian-Wang Guo Excerpt from the article published in Cell Signal. 2020 Nov;75:109732. DOI: 10.1016/j.cellsig.2020.109732. Epub 2020 Aug 2. PMID: 32750415; PMCID: PMC7530065. Editor’s Highlights Abstract The sigma-1 receptor (Sig1R) is a unique ligand-operated endoplasmic reticulum (ER) protein without any mammalian homolog. It has long […]
Continue ReadingSex-specific Effects of α2δ-1 in the Ventromedial Hypothalamus of Female Mice Controlling Glucose and Lipid Balance
By Jennifer A Felsted, Alice Meng, Dominique Ameroso, and Maribel Rios Excerpt from the article published in Endocrinology, Volume 161, Issue 7, July 2020, bqaa068, DOI: https://doi.org/10.1210/endocr/bqaa068 Editor’s Highlights The ventromedial hypothalamus (VMH) plays a well-established role in appetite and body weight regulation as well as in glucose homeostasis and lipid metabolism. Diverse leptin-induced, leptin-inhibited, and […]
Continue ReadingRegulation of the Ca2+ channel α2δ-1 subunit expression by epidermal growth factor via the ERK/ELK-1 signaling pathway
By Paz Duran, Alejandro Sandoval, Ricardo González-Ramírez, Natanael Zarco, and Ricardo Felix Excerpt from the article published in American Journal of Physiology-Endocrinology and Metabolism 2020 319:1, E232-E244 02 JUL 2020 DOI: https://doi.org/10.1152/ajpendo.00007.2020 Editor’s Highlights CaVα2δ-1 auxiliary subunit has been shown to increase the cell-surface expression of HVA CaV channels, it is reasonable to suggest that epidermal growth factor (EGF) may […]
Continue ReadingThe Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates
By Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M.-Y. Lee, John Q. Trojanowski, and Robert H. Mach Excerpt from the article published in Molecular Neurobiology 2020 Sep; 57(9): 3803–3813. Published online 2020 Jun 23. doi: 10.1007/s12035-020-01988-1 Abstract Background: Our lab has recently shown that the Sigma-2 Receptor/Transmembrane Protein 97 (TMEM97) and Progesterone Receptor Membrane Component 1 […]
Continue ReadingAuxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development
By Arthur Bikbaev, Anna Ciuraszkiewicz-Wojciech, Jennifer Heck, Oliver Klatt, Romy Freund, Jessica Mitlöhner, Sara Enrile Lacalle, Miao Sun, Daniele Repetto, Renato Frischknecht, Cornelia Ablinger, Astrid Rohlmann, Markus Missler, Gerald J. Obermair, Valentina Di Biase and Martin Heine Excerpt from the article published in Journal of Neuroscience 17 June 2020, 40 (25) 4824-4841; DOI: https://doi.org/10.1523/JNEUROSCI.1707-19.2020 Highlights This study provides support for the reported association of the α2δ1 coding region (CACNA2D1) and the α2δ3 coding region (CACNA2D3) genetic aberrations with autism and the […]
Continue ReadingPresynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
By Julie Bruyère, Yah-Se Abada, Hélène Vitet, Gaëlle Fontaine, Jean-Christophe Deloulme, Aurélia Cès, Eric Denarier, Karin Pernet-Gallay, Annie Andrieux, Sandrine Humbert, Marie-Claude Potier, Benoît Delatour, and Frédéric Saudou Excerpt from the article published in eLife, May 26, 2020, DOI: https://doi.org/10.7554/eLife.56371 Editor’s Highlights Huntingtin (HTT), the scaffolding protein involved in Huntington’s disease, regulates neuritic transport of amyloid […]
Continue ReadingDistinct Regulation of σ1 Receptor Multimerization by Its Agonists and Antagonists in Transfected Cells and Rat Liver Membranes
By Weimin Conrad Hong Excerpt from the article published in Journal of Pharmacology and Experimental Therapeutics, May 2020, 373 (2) 290-301; DOI: https://doi.org/10.1124/jpet.119.262790 Editor’s Highlights The sigma-1 receptor (σ1R) interacts with and modulates the activity of a plethora of partner proteins, including channels, receptors, and transporters, and regulates their function. Changes in σ1R oligomerization by ligands can modulate the availability of σ1R […]
Continue ReadingSigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis
By Lile Jiang, Jinquan Cui, Cuilian Zhang, Juanke Xie, Shaodi Zhang, Dongjun Fu, and Wei Duo Excerpt from the article published in Aging (Albany NY). 2020; 12:9041-9065. https://doi.org/10.18632/aging.103166 Editor’s Highlights Infertility is a common disease and affects more than 15% of reproductive-age couples. Diminished ovarian reserve (DOR) is found in approximately 10% of infertile women. […]
Continue ReadingProteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
By Annika Höhn, Antonella Tramutola, and Roberta Cascella Excerpt from the article published in OMCL Oxidative Medicine and Cellular Longevity 1942-0994 1942-0900 Hindawi Volume 2020 Article ID 5497046 DOI: https://doi.org/10.1155/2020/5497046 Editor’s Highlights The cellular protein quality control ensures the proper folding of newly synthesized proteins, handling unfolding, refolding, and/or degradation of misfolded proteins. This process is critical as 30% of newly synthesized proteins are prone […]
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