Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration
By Verena Kluever, Belisa Russo, Sunit Mandad, Nisha Hemandhar Kumar, Mihai Alevra, Alessandro Ori, Silvio O. Rizzoli, Henning Urlaub, Anja Schneider, and Eugenio F. Fornasiero Excerpt from the article published in Science Advances, 20 May 2022, Vol 8, Issue 20 DOI: 10.1126/sciadv.abn4437 Editor’s Highlights Physiologically aged brain has revealed only minor alterations in protein abundances in the aged […]
Continue ReadingMitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
By Zonghan Liu, Yi Sun, Zhengtang Qi, Lu Cao, and Shuzhe Ding Excerpt from the article published in Cell and Bioscience 12, 66 (2022). Published: 19 May 2022, DOI: https://doi.org/10.1186/s13578-022-00805-7 Editor’s Highlights Mitochondria are semiautonomous, semiself-replicating, highly dynamic organelles, endowed with their own circular, double-stranded DNA molecule that spans 16.6 kb and intramitochondrial replication and translational machinery. Intercellular mitochondrial […]
Continue ReadingIntracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy
By Sergei Kopanchuk, Edijs Vavers , Santa Veiksina, Kadri Ligi, Liga Zvejniece, Maija Dambrova, and Ago Rinken Excerpt from the article published in PLoS ONE 17(5): e0268563. May 18, 2022, DOI: https://doi.org/10.1371/journal.pone.0268563 Editor’s Highlights The sigma-1 receptor (Sig1R) has been described as an intracellular protein modulator, a chaperone protein that localizes in the endoplasmic reticulum […]
Continue ReadingCellular interorganelle crosstalk in health and disease states: A glimpse on nephrology-related conditions
By Fateme Shamekhi Amiri Excerpt from the article published in Archives of Clinical Nephrology 8(1): 007-027. DOI: 10.17352/acn.000059 Editor’s Highlights Mitochondria as a signalling organelle associates with the cellular signalling environment and mediates gene expression programs. Mitochondria are constantly interacting with other organelles through signalling pathways, and on some occasions even though physical contact sites. Sigma-1receptor […]
Continue ReadingBromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration
By Adonis Sfera, Karina G. Thomas, Christina V. Andronescu, Nyla Jafri, Dan O.Sfera, Sarvin Sasannia, Carlos M. Zapata-Martín del Campo, and Jose C. Maldonado Excerpt from the article published in Frontiers in Neuroscience, volume 16, 2022, https://www.frontiersin.org/article/10.3389/fnins.2022.904816 DOI=10.3389/fnins.2022.904816 Editor’s Highlights Memory and behavioral dysfunction can occur in up to 50% of Human immunodeficiency virus (HIV) […]
Continue ReadingRapid Molecular Diagnosis of Genetically Inherited Neuromuscular Disorders Using Next-Generation Sequencing Technologies
By Sofia Barbosa-Gouveia, Maria Eugenia Vázquez-Mosquera, Emiliano González-Vioque, Álvaro Hermida-Ameijeiras, Paula Sánchez-Pintos, Maria José de Castro, Soraya Ramiro León, Belén Gil-Fournier, Cristina Domínguez-González, Ana Camacho Salas, Luis Negrão, Isabel Fineza, Francisco Laranjeira, and Maria Luz Couce Excerpt from the article published in Journal of Clinical Medicine 11, no. 10: 2750. 12 May 2022 https://doi.org/10.3390/jcm11102750 Editor’s Highlights […]
Continue ReadingStress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP
By Eduardo Pinho Melo, Tasuku Konno, Ilaria Farace, Mosab Ali Awadelkareem, Lise R. Skov, Fernando Teodoro, Teresa P. Sancho, Adrienne W. Paton, James C. Paton, Matthew Fares, Pedro M. R. Paulo, Xin Zhang & Edward Avezov Excerpt from the article published in Nature Communications 13, 2501 (2022). https://doi.org/10.1038/s41467-022-30238-2 Editor’s Highlights The biosynthetic organelles evolved a multi-layer proteostasis […]
Continue ReadingSingle-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease
By Tushar Kamath, Abdulraouf Abdulraouf, S. J. Burris, Jonah Langlieb, Vahid Gazestani, Naeem M. Nadaf, Karol Balderrama, Charles Vanderburg, and Evan Z. Macosko Excerpt from the article published in Nature Neuroscience (2022). https://doi.org/10.1038/s41593-022-01061-1ce Editor’s Highlights A single subtype of dopamine (DA) neurons, marked by the expression of the gene AGTR1 and spatially confined to the ventral tier of the […]
Continue ReadingNeuroimmune cardiovascular interfaces control atherosclerosis
By Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, […]
Continue ReadingSigma-1 Receptor Agonists are Protective in Renal Ischemia/Reperfusion Injury
By Akos Roland Toth, Tamas Lakat, Judit Hodrea, Dora B Balogh, Adam Vannay, Laszlo Wagner, Attila Szabo, Andrea Fekete, and Adam Hosszu Excerpt from the article published in Nephrology Dialysis Transplantation, Volume 37, Issue Supplement_3, May 2022, gfac067.081, https://doi.org/10.1093/ndt/gfac067.081 Editor’s Highlights Sigma-1 receptor agonists act directly on proximal tubular cells by activating the S1R-Akt-eNOS signaling pathway […]
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