Brain Tumor Networks in Diffuse Glioma
By Yvonne Yang, Marc C. Schubert, Thomas Kuner, Wolfgang Wick, Frank Winkler, and Varun Venkataramani Excerpt from the article published in Neurotherapeutics, 10 November 2022. DOI: https://doi.org/10.1007/s13311-022-01320-w Editor’s Highlights Abstract Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and molecular mechanisms driving the invasive growth patterns and therapeutic resistance are incompletely […]
Continue ReadingApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
By Ana-Caroline Raulin, Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu, and Chia-Chen Liu Excerpt from the article published in Molecular Neurodegeneration 17, 72, 8 November 2022, DOI: https://doi.org/10.1186/s13024-022-00574-4 Editor’s Highlights Abstract Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. […]
Continue ReadingAmyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease
By Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, and Oskar Hansson Excerpt from the article published in Nature Communications 13, 6635, 04 November 2022. DOI: https://doi.org/10.1038/s41467-022-34129-4 Editor’s Highlights Abstract For optimal design of anti-amyloid-β (Aβ) […]
Continue ReadingThe Role of the Sigma-2 Receptor in Myocardial Ischemia-Reperfusion Injury
By Radhika Rastogi, Jing Li, Katherine Marsh, Aimee Zhang, Lian-Wang Guo, and Zequan Yang Abstract published in ACUTE CORONARY SYNDROMES, SESSION TITLE: VULNERABILITY AND CONSEQUENCE IN ACS, 30 Oct 2022 Circulation. 2022;146:A14321 Abstract Introduction: Pharmacological studies have identified two subtypes of sigma receptors, which are now known to be encoded by different genes. Activation of the […]
Continue ReadingNeurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders
By Philipp Janz, Marie Bainier, Samuel Marashli, Philipp Schoenenberger, Miguel Valencia, and Roger L. Redondo Excerpt from the article published in Translational Psychiatry volume 12, Article number: 455, 28 October 2022, DOI: https://doi.org/10.1038/s41398-022-02224-1 Editor’s Highlights Neurexins (NRXNs) are a large family of cell adhesion proteins that play a central role in synapse maturation and organization […]
Continue ReadingSigma Antagonists for Treatment of Neuropathic Pain Syndromes in Cancer Patients: A Narrative Review
By Joseph V. Pergolizzi, Jr. and Jo Ann LeQuang Article published in Journal of Cancer Research Updates, 11, 70–77, 2022-10-27, DOI: https://doi.org/10.30683/1929-2279.2022.11.10 Abstract Almost 40% of cancer patients have neuropathic pain or mixed pain with a neuropathic component, which can be intense, debilitating, and challenging to treat. New studies on sigma receptors show these enigmatic ligand-binding […]
Continue ReadingThe synergy of β amyloid 1-42 and oxidative stress in the development of Alzheimer’s disease-like neurodegeneration of hippocampal cells
By Gohar Karapetyan, Katarine Fereshetyan, Hayk Harutyunyan, and Konstantin Yenkoyan Excerpt from the article published in Scientific Reports 12, 17883, 25 October 2022. DOI: https://doi.org/10.1038/s41598-022-22761-5 Editor’s Highlights Alzheimer’s disease (AD) is a neurodegenerative disease that occurs in elderly individuals and which incidence has increased year by year, and there is still no effective drug for treating […]
Continue ReadingMitochondrial biogenesis, telomere length and cellular senescence in Parkinson’s disease and Lewy body dementia
By Muhammad Asghar, Amani Odeh, Ahmad Jouni Fattahi, Alexandra Edwards Henriksson, Aurelie Miglar, Shervin Khosousi, and Per Svenningsson Excerpt from the article published in Scientific Reports 12, 17578, 20 October 2022, DOI: https://doi.org/10.1038/s41598-022-22400-z Editor’s Highlights Although Parkinson’s disease (PD) is a complex disease with several causes, including genetic and environmental factors, progressive age remains the single […]
Continue ReadingProtein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction
By Laura Tapella, Giulia Dematteis, Marianna Moro, Beatrice Pistolato, Elisa Tonelli, Virginia Vita Vanella, Daniele Giustina, Aleida La Forgia, Elena Restelli, Elettra Barberis, Tito Cali, Marisa Brini, Salvatore Villani, Erika Del Grosso, Mariagrazia Grilli, Marcello Manfredi, Marco Corazzari, Ambra A. Grolla, Armando A. Genazzani, and Dmitry Lim Excerpt from the article published in Cell Death […]
Continue ReadingCalcium channel α2δ1 is essential for pancreatic tumor-initiating cells through sequential phosphorylation of PKM2
By Jingtao Liu, Ming Tao, Wei Zhao, Qingru Song, Xiaodan Yang, Meng Li, Yanhua Zhang, Dianrong Xiu, and Zhiqian Zhang Journal Pre-proof to appear in Cellular and Molecular Gastroenterology and Hepatology. Accepted Date: 7 October 2022. DOI: https://doi.org/10.1016/j.jcmgh.2022.10.006 Abstract Background & Aims Tumor-initiating cells (TICs) drive pancreatic cancer tumorigenesis, therapeutic resistance and metastasis. However, TICs […]
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