PLD3 affects axonal spheroids and network defects in Alzheimer’s disease
By Peng Yuan, Mengyang Zhang, Lei Tong, Thomas M. Morse, Robert A. McDougal, Hui Ding, Diane Chan, Yifei Cai, and Jaime Grutzendler Excerpt from the article published in Nature, 30 November 2022. DOI: https://doi.org/10.1038/s41586-022-05491-6 Editor’s Highlights Abstract The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal […]
Continue ReadingProteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
By Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro Nakamura, Naoko […]
Continue ReadingA Novel Huntington’s Disease Assessment Platform to Support Future Drug Discovery and Development
By Jingyun Wu, Luisa Möhle, Thomas Brüning Iván Eiriz, Muhammad Rafehi, Katja Stefan, Sven Marcel Stefan, and Jens Pahnke Excerpt from the article published in International Journal of Molecular Sciences 23, no. 23: 14763, 25 November 2022. DOI: https://doi.org/10.3390/ijms232314763 Editor’s Highlights Abstract Huntington’s disease (HD) is a lethal neurodegenerative disorder without efficient therapeutic options. The inefficient translation […]
Continue ReadingMitochondrial Ca2+ Signaling and Bioenergetics in Alzheimer’s Disease
By Nikita Arnst, Nelly Redolfi, Annamaria Lia, Martina Bedetta, Elisa Greotti, and Paola Pizzo Excerpt from the article Biomedicines 10, no. 12: 3025. 24 November 2022. DOI: https://doi.org/10.3390/biomedicines10123025 Editor’s Highlights Abstract Alzheimer’s disease (AD) is a hereditary and sporadic neurodegenerative illness defined by the gradual and cumulative loss of neurons in specific brain areas. The processes […]
Continue ReadingInsights on the Role of PGRMC1 in Mitotic and Meiotic Cell Division
By Valentina Lodde, Rodrigo Garcia Barros, Laura Terzaghi, Federica Franciosi, and Alberto Maria Luciano Excerpt from the article published in Cancers 14, no. 23: 5755. 23 November 2022. DOI: https://doi.org/10.3390/cancers14235755 Editor’s Highlights Simple Summary PGRMC1 is a multifunctional protein regulating multiple aspects of cell proliferation, including cell viability, apoptosis, entry into the cell cycle, and the […]
Continue ReadingProtein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders
By Aleksandra Ochneva, Yana Zorkina, Olga Abramova, Olga Pavlova, Valeriya Ushakova, Anna Morozova, Eugene Zubkov, Konstantin Pavlov, Olga Gurina, and Vladimir Chekhonin Excerpt from the article published in International Journal of Molecular Sciences 23, no. 22: 14498. 21 November 2022, DOI: https://doi.org/10.3390/ijms232214498 Editor’s Highlights Abstract Mental disorders represent common brain diseases characterized by substantial impairments of […]
Continue ReadingSigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling
By Christelle Lasbleiz, Amandine Peyrel, Pauline Tarot, Jérôme Sarniguet, Lucie Crouzier, Nicolas Cubedo, Benjamin Delprat, Mireille Rossel, Tangui Maurice, Jean-Charles Liévens Excerpt from the article published in Redox Biology, 17 November 2022, 102542, ISSN 2213-2317,DOI: https://doi.org/10.1016/j.redox.2022.102542. Editor’s Highlights Autors’ Highlights Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons. […]
Continue ReadingEffects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats
By Sándor Váczi, Lilla Barna, Krisztián Laczi, Ferenc Tömösi, Gábor Rákhely, Botond Penke, Lívia Fülöp, Ferenc Bogár, Tamás Janáky, Mária A. Deli, and Zsófia Mezei Excerpt from the article published in Plos One on November 17, 2022, DOI: https://doi.org/10.1371/journal.pone.0265854 Editor’s Highlights Abstract Background: Diabetes mellitus is a chronic metabolic disorder which induces endothelial dysfunction and […]
Continue ReadingSigma-1 receptor agonist, (+)-pentazocine, is neuroprotective in a Brown Norway rat microbead model of glaucoma
By Barbara A. Mysona, Jing Zhao, Oceane De Greef, August Beisel, Parth A. Patel, Lindsay Berman, Sylvia B. Smith, and Kathryn Bollinger Excerpt from the article published in Experimental Eye Research, 15 November 2022, 109308, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2022.109308. Abstract Purpose: Glaucoma is a worldwide leading cause of irreversible blindness. Standard treatments lower intraocular pressure […]
Continue ReadingThe regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment
By Hongji Sun, Mengxue Wu, Minxin Wang, Xiaomin Zhang, and Jia Zhu Excerpt from the article published in Frontiers of Neuroscience, 15 November 2022, Sec. Neurodevelopment, DOI: https://doi.org/10.3389/fnins.2022.1032607 Editor’s Highlights Abstract The endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid […]
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