Activation of the sigma-1 receptor ameliorates neuronal ferroptosis via IRE1α after spinal cord injury
By Rui Tan, Chunxiao Sui, Yuhang Diao, Guihong Shi, Xiaojun Hu, Zhenghao Hao, Chenyang Li, Mingyu Hao, Minghao Xie, and Tao Zhu Excerpt from the article published in Brain Research, May 18 2024, 149011, ISSN 0006-8993, DOI:https://doi.org/10.1016/j.brainres.2024.149011. Highlights Abstract Spinal Cord Injury (SCI) is a debilitating disease associated with a significant economic burden owing to […]
Continue ReadingHighly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response
By Muhammad Saad Yousuf, James J. Sahn, Hongfen Yang, Eric T. David, Stephanie Shiers, Marisol Mancilla Moreno, Jonathan Iketem, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Subhaan M. Mian, Ayesha Ahmad, Benedict J. Kolber, Daniel J. Liebl, Stephen F. Martin, and Theodore J. Price Excerpt from the article published in Proceedings […]
Continue ReadingA Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain
By Bin Shen, Daehyun Yoon, Jessa Castillo, and Sandip Biswal Excerpt from the article published in Semin Musculoskelet Radiol, November 2023; 27(06): 601-617 DOI: 10.1055/s-0043-1775744 Editor’s Highlights Abstract Accurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from […]
Continue ReadingSigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain
By Simona Denaro, Lorella Pasquinucci, Rita Turnaturi, Cristiana Alberghina, Lucia Longhitano, Sebastiano Giallongo, Giuliana Costanzo, Salvatore Spoto, Margherita Grasso, Agata Zappalà, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti, and Carmela Parenti Excerpt from the article published in Mol Neurobiol (November 3, 2023). DOI: https://doi.org/10.1007/s12035-023-03717-w Editor’s Highlights Abstract Neuropathic pain is one of the most […]
Continue ReadingSigma1 Regulates Lipid Droplet–Mediated Redox Homeostasis Required for Prostate Cancer Proliferation
By Halley M. Oyer; Alexandra R. Steck; Charles G. Longen; Sanjana Venkat; Konuralp Bayrak; Eleanor B. Munger; Dan Fu; Paola A. Castagnino; Christina M. Sanders; Nathalia A. Tancler; My T. Mai; Justin P. Myers; Matthew J. Schiewer; Nan Chen; Elahe A. Mostaghel; and Felix J. Kim Excerpt from the article published in Cancer Research Communications (October […]
Continue ReadingGenetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice
By Sergio López-Estévez, Mònica Aguilera, Georgia Gris, Beatriz de la Puente, Alicia Carceller, and Vicente Martínez Excerpt from the article published in Biomedicines. 12 October 2023; 11(10):2758. DOI: https://doi.org/10.3390/biomedicines11102758 Editor’s Highlights Abstract Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute colitis-associated hypersensitivity using […]
Continue ReadingSigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors
By M. Carmen Ruiz-Cantero, Miguel Á. Huerta, Miguel Á. Tejada, Miriam Santos-Caballero, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Entrena, José M. Baeyens, and Enrique J. Cobos Excerpt from the article published in Biomedicine & Pharmacotherapy, Volume 167, November 2023, 115534, ISSN 0753-3322, DOI: https://doi.org/10.1016/j.biopha.2023.115534. Highlights Abstract The analgesic effects of sigma-1 antagonists are undisputed, but the […]
Continue ReadingSigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury
By Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, and Anand Veeravagu Excerpt from the article published in Scientific Reports 13, 14762 (07 September 2023). DOI: https://doi.org/10.1038/s41598-023-42063-8 Editor’s Highlights Abstract Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been […]
Continue ReadingThe Emerging Role of Sigma Receptors in Pain Medicine
By Joseph Pergolizzi Jr and Giustino Varrassi Excerpt from the article published in Cureus 15(7): e42626. July 28, 2023, doi:10.7759/cureus.42626 Abstract Sigma receptors are protein chaperones with the unexpected characteristic of being activated by ligand binding. As such, they represent intriguing new targets for potential drug development. As a protein chaperone, these “receptors” escort proteins from […]
Continue ReadingValidation of σ2R/TMEM97 as a neuropathic pain target: Specificity, human expression and mechanism of action
By Muhammad Saad Yousuf, James J. Sahn, Eric T. David, Stephanie Shiers, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Ayesha Ahmad, Benedict J. Kolber, Daniel J Liebl, Stephen F. Martin, and Theodore J. Price Excerpt from the article published in bioRxiv 2023.04.11., 536439; DOI: https://doi.org/10.1101/2023.04.11.536439 Editor’s Highlights Abstract The Sigma 2 receptor (σ2R) […]
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