Category Archives: Neuropathic Pain

A Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain

A Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain

By Bin Shen, Daehyun Yoon, Jessa Castillo, and Sandip Biswal Excerpt from the article published in Semin Musculoskelet Radiol, November 2023; 27(06): 601-617 DOI: 10.1055/s-0043-1775744 Editor’s Highlights Abstract Accurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from […]

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Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain

Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain

By Simona Denaro, Lorella Pasquinucci, Rita Turnaturi, Cristiana Alberghina, Lucia Longhitano, Sebastiano Giallongo, Giuliana Costanzo, Salvatore Spoto, Margherita Grasso, Agata Zappalà, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti, and Carmela Parenti Excerpt from the article published in Mol Neurobiol (November 3, 2023). DOI: https://doi.org/10.1007/s12035-023-03717-w Editor’s Highlights Abstract Neuropathic pain is one of the most […]

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Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice

Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice

By Sergio López-Estévez, Mònica Aguilera, Georgia Gris, Beatriz de la Puente, Alicia Carceller, and Vicente Martínez Excerpt from the article published in Biomedicines. 12 October 2023; 11(10):2758. DOI: https://doi.org/10.3390/biomedicines11102758 Editor’s Highlights Abstract Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute colitis-associated hypersensitivity using […]

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Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

By M. Carmen Ruiz-Cantero, Miguel Á. Huerta, Miguel Á. Tejada, Miriam Santos-Caballero, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Entrena, José M. Baeyens, and Enrique J. Cobos Excerpt from the article published in Biomedicine & Pharmacotherapy, Volume 167, November 2023, 115534, ISSN 0753-3322, DOI: https://doi.org/10.1016/j.biopha.2023.115534. Highlights Abstract The analgesic effects of sigma-1 antagonists are undisputed, but the […]

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Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury

Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury

By Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, and Anand Veeravagu Excerpt from the article published in Scientific Reports 13, 14762 (07 September 2023). DOI: https://doi.org/10.1038/s41598-023-42063-8 Editor’s Highlights Abstract Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been […]

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The Emerging Role of Sigma Receptors in Pain Medicine

The Emerging Role of Sigma Receptors in Pain Medicine

By Joseph Pergolizzi Jr and Giustino Varrassi Excerpt from the article published in Cureus 15(7): e42626. July 28, 2023, doi:10.7759/cureus.42626 Abstract Sigma receptors are protein chaperones with the unexpected characteristic of being activated by ligand binding. As such, they represent intriguing new targets for potential drug development. As a protein chaperone, these “receptors” escort proteins from […]

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Validation of σ2R/TMEM97 as a neuropathic pain target: Specificity, human expression and mechanism of action

Validation of σ2R/TMEM97 as a neuropathic pain target: Specificity, human expression and mechanism of action

By Muhammad Saad Yousuf, James J. Sahn, Eric T. David, Stephanie Shiers, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Ayesha Ahmad, Benedict J. Kolber, Daniel J Liebl, Stephen F. Martin, and Theodore J. Price Excerpt from the article published in bioRxiv 2023.04.11., 536439;  DOI: https://doi.org/10.1101/2023.04.11.536439 Editor’s Highlights Abstract The Sigma 2 receptor (σ2R) […]

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TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy

TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy

By Aida Marcotti, Jorge Fernández-Trillo, Alejandro González, Marta Vizcaíno-Escoto, Pablo Ros-Arlanzón, Luz Romero, José Miguel Vela, Ana Gomis, Félix Viana, and Elvira de la Peña Excerpt from the article published in Brain, Volume 146, Issue 2, February 2023, Pages 475–491, DOI: https://doi.org/10.1093/brain/awac273 Editor’s Highlights Abstract Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer […]

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