Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke
By Gufang Zhang, Qi Li, Weijie Tao, Pingping Qin, Jiali Chen, Huicui Yang, Jiaojiao Chen, Hua Liu, Qijun Dai, and Xuechu Zhen Excerpt from the article published in Theranostics. 2023 Jan 1;13(2):543-559. DOI: 10.7150/thno.77088. PMID: 36632219; PMCID: PMC9830433. Editor’s Highlights Abstract Background: Efferocytosis of apoptotic neurons by macrophages is essential for the resolution of inflammation and […]
Continue ReadingSigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes
By Hideaki Tagashira, Md. Shenuarin Bhuiyan, Yasuharu Shinoda, Ichiro Kawahata, Tomohiro Numata, and Kohji Fukunaga Introduction to the article published in Journal of Pharmacological Sciences, December 10, 2022, ISSN 1347-8613, DOI: https://doi.org/10.1016/j.jphs.2022.12.005. Editor’s Highlights Abstract The Sigma-1 receptor (Sigmar1) is downregulated in heart failure model mice with mitochondrial dysfunction. However, the mechanism in detail has […]
Continue ReadingRetinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
By Timur A. Mavlyutov, Jing Li, Xinying Liu, Hongtao Shen, Huan Yang, Christopher R. McCurdy, Bikash Pattnaik, and Lian-Wang Guo Excerpt from the article published in Genes 13(12):2386, 16 December 2022, DOI: https://doi.org/10.3390/genes13122386 Editor’s Highlights Abstract The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding […]
Continue Readingσ2R/TMEM97 in retinal ganglion cell degeneration
By Hua Wang, Zhiyou Peng, Yiwen Li, James J. Sahn, Timothy R. Hodges, Tsung-Han Chou, Qiong Liu, Xuezhi Zhou, Shuliang Jiao, Vittorio Porciatti, Daniel J. Liebl, Stephen F. Martin, and Rong Wen Excerpt from the article published in Scientific Reports 12, 20753, 01 December 2022, DOI: https://doi.org/10.1038/s41598-022-24537-3 Editor’s Highlights Abstract The sigma 2 receptor (σ2R) […]
Continue ReadingSigma-1 receptor agonist, (+)-pentazocine, is neuroprotective in a Brown Norway rat microbead model of glaucoma
By Barbara A. Mysona, Jing Zhao, Oceane De Greef, August Beisel, Parth A. Patel, Lindsay Berman, Sylvia B. Smith, and Kathryn Bollinger Excerpt from the article published in Experimental Eye Research, 15 November 2022, 109308, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2022.109308. Abstract Purpose: Glaucoma is a worldwide leading cause of irreversible blindness. Standard treatments lower intraocular pressure […]
Continue ReadingThe Role of the Sigma-2 Receptor in Myocardial Ischemia-Reperfusion Injury
By Radhika Rastogi, Jing Li, Katherine Marsh, Aimee Zhang, Lian-Wang Guo, and Zequan Yang Abstract published in ACUTE CORONARY SYNDROMES, SESSION TITLE: VULNERABILITY AND CONSEQUENCE IN ACS, 30 Oct 2022 Circulation. 2022;146:A14321 Abstract Introduction: Pharmacological studies have identified two subtypes of sigma receptors, which are now known to be encoded by different genes. Activation of the […]
Continue ReadingMitochondria-Associated Endoplasmic Reticulum Membranes: Inextricably Linked with Autophagy Process
By Chonghao Ji, Zhanwei Zhang, Zechuan Li, Xiao She, Xiaoya Wang, Binyang Li, Xin Xu, Dawei Song, and Dongjiao Zhang Excerpt from the article published in Oxidative Medicine and Cellular Longevity (Hindawi), Volume 2022, 23 Aug 2022, Article ID 7086807, DOI: https://doi.org/10.1155/2022/7086807 Editor’s Highlights There is a growing body of evidence indicating Mitochondria-associated membranes (MAMs) act as […]
Continue ReadingActivation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis
By Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu, and Bo Yang Excerpt from the article published in Molecular Medicine volume 28, Article number: 87, 03 August 2022, DOI: https://doi.org/10.1186/s10020-022-00517-1 Editor’s Highlights With the increase of global aging population, the incidence of Heart Failure (HF) has increased […]
Continue ReadingSigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
By Zifen Xu, Yushuang Lei, Huan Qin, Shiyao Zhang, Ping Li, and Kai Yao Excerpt from the article published in International Journal of Molecular Sciences 23, no. 14: 7572. Published: 8 July 2022, DOI: https://doi.org/10.3390/ijms23147572 Editor’s Highlights The sigma-1 receptor is widely expressed in several organs, such as endocrine, immune, and reproductive tissues, the liver, kidney, […]
Continue Reading(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration
By Manjuan Peng, Xuezhi Zhou, Fei Yao, Haibo Li, Weitao Song, Siqi Xiong, and Xiaobo Xia Excerpt from the article published in Frontiers in Medicine, volume 9, 27 June 2022, DOI: https://doi.org/10.3389/fmed.2022.879901 Editor’s Highlights Dry age-related macular degeneration (AMD) accounts for approximately 5.8% of legal blindness globally and is the leading cause of severe vision […]
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