Cardiovascular - Advantx Pharmaceuticals Inc.

Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction

By Remex Naznin Sultana , Abdullah Chowdhury S. , Aishwarya Richa , Kolluru Gopi K. , Traylor James , Bhuiyan Mohammad Alfrad Nobel , Kevil Christopher G. , Orr A. Wayne , Rom Oren , Pattillo Christopher B. , and Bhuiyan Md. Shenuarin Excerpt of the article published in Frontiers in Physiology, 15, 29 April […]

Multi-Omics Analysis Reveals the Role of Sigma-1 Receptor in a Takotsubo-like Cardiomyopathy Model

By Yi Liu, Qing Chen, Jian-Zheng Yang, Xiu-Wen Li, Li-Jian Chen, Kai-Kai Zhang, Jia-Li Liu, Jia-Hao Li, Clare Hsu, Long Chen, Jia-Hao Zeng, Qi Wang, Dong Zhao, and Jing-Tao Xu Excerpt from the article published in Biomedicines. 12 October 2023; 11(10):2766. DOI: https://doi.org/10.3390/biomedicines11102766 Editor’s Highlights Abstract Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy that presents […]

The Neuroprotective Effect of Activation of Sigma-1 Receptor on Neural Injury by Optic Nerve Crush

By Yao Chen; Xueli Yang; and Junfeng Mao Excerpt from the article published in Investigative Ophthalmology & Visual Science September 2023, Vol.64, 9. Doi:https://doi.org/10.1167/iovs.64.12.9 Editor’s Highlights Abstract Purpose: This study aimed to explore the neuroprotective effects of sigma-1 receptor (S1R) on optic nerve crush (ONC) mice by upregulating its expression through intravitreal injection of adeno-associated virus (AAV). […]

Sigma-1 receptor knockout disturbs gut microbiota, remodels serum metabolome, and exacerbates isoprenaline-induced heart failure

By Jian-Zheng Yang, Kai-Kai Zhang, Hong-Wu Shen, Yi Liu, Xiu-Wen Li, Li-Jian Chen, Jia-Li Liu, Jia-Hao Li, Dong Zhao, Qi Wang, and Chu-Song Zhou Excerpt from the article published in Frontiers Microbiology, 31 August 2023, Sec. Microorganisms in Vertebrate Digestive Systems, Volume 14 – 2023, DOI: https://doi.org/10.3389/fmicb.2023.1255971 Editor’s Highlights Abstract Introduction: Heart failure (HF) is usually the […]

Sigma 1 receptor activation improves retinal structure and function in the RhoP23H/+ mouse model of autosomal dominant retinitis pigmentosa

By Shannon R. Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, and Sylvia B. Smith Extract from the article published in Experimental Eye Research, Volume 230, May 2023, 109462, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2023.109462 Editor’s Highlights Abstract Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to visual impairment and oftentimes complete blindness. Currently no […]

Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels

By Remex Naznin Sultana, Abdullah Chowdhury S., Aishwarya Richa, Nitu Sadia S., Traylor James, Hartman Brandon, King Judy, Bhuiyan Mohammad Alfrad Nobel, Kevil Christopher G., Orr A. Wayne, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 14, 27 March 2023Sec. Respiratory Physiology and Pathophysiology, ISSN 1664-042X, DOI: 10.3389/fphys.2023.1118770 Editor’s […]

Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

By Alba Vera-Zambrano, Maria Baena-Nuevo, Susanne Rinné, Marta Villegas-Esguevillas, Bianca Barreira, Gokcen Telli, Angela de Benito-Bueno, José Antonio Blázquez, Belén Climent, Francisco Pérez-Vizcaino, Carmen Valenzuela, Niels Decher, Teresa Gonzalez, and Angel Cogolludo Excerpt from the article published in Pharmacological Research, Volume 189, March 2023, 106684,ISSN 1043-6618, DOI: https://doi.org/10.1016/j.phrs.2023.106684. Editor’s Highlights Abstract KV1.5 channels are key […]

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes

By Jiang-Hui Wang, Daniel Urrutia-Cabrera, Jarmon G. Lees, Santiago Mesa Mora, Tu Nguyen, Sandy S. C. Hung, Alex W. Hewitt, Shiang Y. Lim, Thomas L. Edwards, and Raymond C. B. Wong Excerpt from the article published in the International Journal of Molecular Sciences. 8 February 2023; 24(4):3417. DOI: https://doi.org/10.3390/ijms24043417 Editor’s Highlights Abstract Age-related macular degeneration […]

Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases

By Francisco Javier Munguia-Galaviz, Alejandra Guillermina Miranda-Diaz, Miguel Alejandro Cardenas-Sosa, and Raquel Echavarria Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1997. DOI: https://doi.org/10.3390/ijms24031997 Editor’s Hihghlights Abstract Cardiovascular and renal diseases are among the leading causes of death worldwide, and regardless of current efforts, there is a demanding […]

Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus

By Wenjing Song, Yang Yao, Heling Zhang, Xin Hao, Liping Zhou, Zhixiao Song, Tiantian Wei, Tianyan Chi, Peng Liu, Xuefei Ji, and Libo Zou Excerpt from the article published in Molecules 2023, 28(1), 390; 2 January 2023; DOI: https://doi.org/10.3390/molecules28010390 Editor’s Highlights Abstract Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in […]

Category Archives: Cardiovascular