GRP78 Overexpression Triggers PINK1-IP3R-Mediated Neuroprotective Mitophagy
By Tatiana Leiva-Rodríguez, David Romeo-Guitart, Mireia Herrando-Grabulosa, Pau Muñoz-Guardiola, Miriam Polo, Celia Bañuls Valerie Petegnief, Assumpció Bosch, Jose Miguel Lizcano, Nadezda Apostolova, Joaquim Forés, and Caty Casas Excerpt from the article published in Biomedicines 2021, 9, 1039. Published: 18 August 2021, DOI: https://doi.org/10.3390/biomedicines9081039 Editor’s Highlights GRP78, also known as BiP or heat shock protein 5a (HSP5a), is […]
Continue ReadingSigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress
By Koshenov, Z.; Oflaz, F.E.; Hirtl, M.; Pilic, J.; Bachkoenig, O.A.; Gottschalk, B.; Madreiter-Sokolowski, C.T.; Rost, R.; Malli, R.; Graier, W.F. Excerpt from the article published in Metabolites 2021, 11, 422. Published: 26 June 2021, DOI: https://doi.org/10.3390/metabo11070422 Editor’s Highlights The endoplasmic reticulum (ER) is a complex, multifunctional organelle of eukaryotic cells and responsible for the trafficking and […]
Continue ReadingThe Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation
By Dominique Fernández, Antonia Geisse, Jose Ignacio Bernales, Alonso Lira, and Fabiola Osorio Excerpt from the article published in Frontiers of Aging Neuroscience, 11 June 2021, Sec. Cellular and Molecular Mechanisms of Brain-aging, DOI: https://doi.org/10.3389/fnagi.2021.682633 Editor’s Highlights Cells possess regulatory mechanisms that maintain proteostasis in conditions that overload the folding capacity of the organelle (a […]
Continue ReadingThe Role of Astrocytes in the Neurorepair Process
By Raphaela Almeida Chiareli, Gustavo Almeida Carvalho, Bruno Lemes Marques, Lennia Soares Mota, Onésia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Alexander Birbrair, Renato Santiago Gomez, Fabrício Simão, Friederike Klempin, Marcel Leist, and Mauro Cunha Xavier Pinto Excerpt from the article published in Frontiers in Cell and Developmental Biology, 25 May 2021 | https://doi.org/10.3389/fcell.2021.665795 Editor’s Highlights Astrocytes […]
Continue ReadingAxonal generation of amyloid-b from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
By Raja Bhattacharyya, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn, Mehdi Jorfi, Dora M. Kovacs, Rudolph E. Tanzi Excerpt from the article published in Cell Rep. May 18, 2021 DOI: https://doi.org/10.1016/j.celrep.2021.109134 Editor’s Highlights Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology To transport proteins to the cell […]
Continue ReadingThe ER protein Ema19 [tmem97] facilitates the degradation of nonimported mitochondrial precursor proteins
![The ER protein Ema19 [tmem97] facilitates the degradation of nonimported mitochondrial precursor proteins](https://advantx.org/wp-content/uploads/2016/11/slide-2-1100x550.jpg)
By Janina Laborenz, Yury S. Bykov, Katharina Knöringer, Markus Räschle, Sabine Filker, Cristina Prescianotto-Baschong, Anne Spang, Takashi Tatsuta, Thomas Langer, Zuzana Storchová, Maya Schuldiner, and Johannes M. Herrmann Excerpt from the article published on Molecular Biology of the Cell, Volume 32, Issue 8, Published Online: 13 Apr 2021, DOI: https://doi.org/10.1091/mbc.E20-11-0748 Editor’s Highlights Ema19 is the […]
Continue ReadingTMEM97 increases in synapses and is a potential synaptic Aβ binding partner in human Alzheimer’s disease
By Martí Colom-Cadena, Jane Tulloch, Rosemary J Jackson, James H Catterson, Jamie Rose, Caitlin Davies, Monique Hooley, Alejandro Anton-Fernandez, Sophie Dunnett, Robert Tempelaar, Makis Tzioras, Nicholas J Izzo, Susan M. Catalano, Colin Smith, and Tara L. Spires-Jones Excerpt from the article published in bioRxiv 2021.02.01, 428238; DOI: https://doi.org/10.1101/2021.02.01.428238 Editor’s Highlights Abstract Synapse loss correlates with cognitive decline in […]
Continue Readingα-Synuclein modulates tau spreading in mouse brains
By Fares Bassil, Emily S. Meymand, Hannah J. Brown, Hong Xu, Timothy O. Cox, Shankar Pattabhiraman, Chantal M. Maghames, Qihui Wu, Bin Zhang, John Q. Trojanowski, and Virginia M.-Y. Lee Excerpt from the article published in Journal of Experimental Medicine, 4 January 2021; 218 (1): e20192193. DOI: https://doi.org/10.1084/jem.20192193 Editor’s Highlights Neuropathological data obtained from Parkinson’s disease (PD) […]
Continue ReadingSigma-2 Receptor—A Potential Target for Cancer/Alzheimer’s Disease Treatment via Its Regulation of Cholesterol Homeostasis
By Kai Yang, Cheng Zeng, Changcai Wang, Meng Sun, Dan Yin, and Taolei Sun Excerpt from the article published in Molecules 25, no. 22: 5439, 2020 https://doi.org/10.3390/molecules25225439 Editor’s Highlights Recently transmembrane protein 97 (TMEM97) was identified as a sigma-2 receptor identity using mass spectrometry after affinity purification from the liver. TMEM97/sigma-2 receptor forms a trimeric complex […]
Continue ReadingThe Sigma-2 Receptor, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates
by Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M.-Y. Lee, John Q. Trojanowski, and Robert H. Mach Excerpt from the article published in final edited form as: Mol Neurobiol. 2020 September DOI: 10.1007/s12035-020-01988-1 Editor’s Highlights Sigma-2 receptor (TMEM97) and PGRMC1 are therapeutic targets for inhibiting neuronal uptake of Aβ42 and ApoE-associated Aβ42 and potentially […]
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