Category Archives: Alzheimer

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

By Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire […]

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Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain

Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain

By Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M. Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I. McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian et al. Excerpt from the article published in Neuron, Elsevier, May 15, 2023, DOI: https://doi.org/10.1016/j.neuron.2023.04.020 Highlights Summary In Alzheimer’s […]

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Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

By Andrew M. Stern,Yang Yang,Shanxue Jin,Keitaro Yamashita,Angela L. Meunier,Wen Liu,Yuqi Cai,Maria Ericsson,Lei Liu,Michel Goedert,Sjors H.W. Scheres, and Dennis J. Selkoe Excerpt from the article published in Neuron, May 10, 2023 DOI: https://doi.org/10.1016/j.neuron.2023.04.007 Highlights Summary Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in supernatants following ultracentrifugation of aqueous extracts from Alzheimer’s disease […]

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SIGMAR1 Confers Innate Resilience against Neurodegeneration

SIGMAR1 Confers Innate Resilience against Neurodegeneration

By Simon Couly, Yuko Yasui, and Tsung-Ping Su Excerpt from the article published in the International Journal of Molecular Sciences 24, no. 9: 7767. 24 April 2023, DOI: https://doi.org/10.3390/ijms24097767 Abstract The sigma-1 receptor (SIGMAR1) is one of a kind: a receptor chaperone protein. This 223 amino acid-long protein is enriched at the mitochondria-associated endoplasmic reticulum membrane […]

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Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases

Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases

By Britney N. Lizama, Jennifer Kahle, Susan M. Catalano, Anthony O. Caggiano, Michael Grundman, and Mary E. Hamby Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6251. 26 March 2023. DOI: https://doi.org/10.3390/ijms24076251 Editor’s Highlights Abstract There is a large unmet medical need to develop disease-modifying treatment options for individuals with age-related […]

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Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

By Véronik Lachance, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, and Saïd Kourrich Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1971. DOI: https://doi.org/10.3390/ijms24031971 Editor’s Highlights Abstract For the past several years, fundamental research on Sigma-1R (S1R) […]

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Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection

Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection

By Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 24, no. 1: 823. 3 January 2023, DOI: https://doi.org/10.3390/ijms24010823 Editor’s Highlights Abstract Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease […]

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Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration

Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration

By Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, and Thomas K Karikari Excerpt from the article published in Brain, 27 December 2022; awac407, DOI: https://doi.org/10.1093/brain/awac407 Editor’s Highlights Abstract Blood-based […]

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Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks

Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks

By Bárbara Avelar-Pereira, Michael E. Belloy, Ruth O’Hara, and S. M. Hadi Hosseini for the Alzheimer’s Disease Neuroimaging Initiative Excerpt from the article published in Molecular Psychiatry. 20 December 2022, DOI: https://doi.org/10.1038/s41380-022-01886-z Editor’s Highlights Abstract Alzheimer’s disease (AD) is a multifactorial and heterogeneous disorder, which makes early detection a challenge. Studies have attempted to combine […]

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