N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk
By Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang, and Zhang-Jin Zhang Excerpt from the article published in Alzheimer’s Research & Therapy volume 16, 95, 01 May 2024, DOI: https://doi.org/10.1186/s13195-024-01462-3 Abstract Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology […]
Continue ReadingTransmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
By Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire […]
Continue ReadingSynaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain
By Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M. Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I. McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian et al. Excerpt from the article published in Neuron, Elsevier, May 15, 2023, DOI: https://doi.org/10.1016/j.neuron.2023.04.020 Highlights Summary In Alzheimer’s […]
Continue ReadingAbundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains
By Andrew M. Stern,Yang Yang,Shanxue Jin,Keitaro Yamashita,Angela L. Meunier,Wen Liu,Yuqi Cai,Maria Ericsson,Lei Liu,Michel Goedert,Sjors H.W. Scheres, and Dennis J. Selkoe Excerpt from the article published in Neuron, May 10, 2023 DOI: https://doi.org/10.1016/j.neuron.2023.04.007 Highlights Summary Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in supernatants following ultracentrifugation of aqueous extracts from Alzheimer’s disease […]
Continue ReadingSIGMAR1 Confers Innate Resilience against Neurodegeneration
By Simon Couly, Yuko Yasui, and Tsung-Ping Su Excerpt from the article published in the International Journal of Molecular Sciences 24, no. 9: 7767. 24 April 2023, DOI: https://doi.org/10.3390/ijms24097767 Abstract The sigma-1 receptor (SIGMAR1) is one of a kind: a receptor chaperone protein. This 223 amino acid-long protein is enriched at the mitochondria-associated endoplasmic reticulum membrane […]
Continue ReadingSigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases
By Britney N. Lizama, Jennifer Kahle, Susan M. Catalano, Anthony O. Caggiano, Michael Grundman, and Mary E. Hamby Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6251. 26 March 2023. DOI: https://doi.org/10.3390/ijms24076251 Editor’s Highlights Abstract There is a large unmet medical need to develop disease-modifying treatment options for individuals with age-related […]
Continue ReadingOverview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection
By Véronik Lachance, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, and Saïd Kourrich Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1971. DOI: https://doi.org/10.3390/ijms24031971 Editor’s Highlights Abstract For the past several years, fundamental research on Sigma-1R (S1R) […]
Continue ReadingAβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
By Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, […]
Continue ReadingChaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection
By Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 24, no. 1: 823. 3 January 2023, DOI: https://doi.org/10.3390/ijms24010823 Editor’s Highlights Abstract Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease […]
Continue ReadingBrain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration
By Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, and Thomas K Karikari Excerpt from the article published in Brain, 27 December 2022; awac407, DOI: https://doi.org/10.1093/brain/awac407 Editor’s Highlights Abstract Blood-based […]
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