The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates
By Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M.-Y. Lee, John Q. Trojanowski, and Robert H. Mach Excerpt from the article published in Molecular Neurobiology 2020 Sep; 57(9): 3803–3813. Published online 2020 Jun 23. doi: 10.1007/s12035-020-01988-1 Abstract Background: Our lab has recently shown that the Sigma-2 Receptor/Transmembrane Protein 97 (TMEM97) and Progesterone Receptor Membrane Component 1 […]
Continue ReadingProteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
By Annika Höhn, Antonella Tramutola, and Roberta Cascella Excerpt from the article published in OMCL Oxidative Medicine and Cellular Longevity 1942-0994 1942-0900 Hindawi Volume 2020 Article ID 5497046 DOI: https://doi.org/10.1155/2020/5497046 Editor’s Highlights The cellular protein quality control ensures the proper folding of newly synthesized proteins, handling unfolding, refolding, and/or degradation of misfolded proteins. This process is critical as 30% of newly synthesized proteins are prone […]
Continue ReadingAmyloid, APP, and Electrical Activity of the Brain
By Dimity Hefter, Susann Ludewig, Andreas Draguhn, and Martin Korte Amyloid Excerpt from the article published in Neuroscientist. 2020;26(3):231-251. Doi: https://doi.org/10.1177/1073858419882619 Editor’s Highlights Abstract The Amyloid Precursor Protein (APP) is infamous for its proposed pivotal role in the pathogenesis of Alzheimer’s disease (AD). Much research on APP focusses on potential contributions to neurodegeneration, mostly based […]
Continue ReadingSigma-2 receptor as a potential therapeutic target for treating central nervous system disorders
by Terada K, Migita K, Matsushima Y, Kamei C. Excerpt from the article published in Neural Regen Res 2019;14:1893-4 DOI: 10.4103/1673-5374.259609 The sigma receptor (Sig-R) was first reported by Martin et al. (1976) and was initially classified into the opioid receptor family. However, Sig-R was subsequently found to differ from the opioid receptor in various studies […]
Continue ReadingSigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex
By Aladdin Riad, Chenbo Zeng, Chi-Chang Weng, Harrison Winters, Kuiying Xu, Mehran Makvandi, Tyler Metz, Sean Carlin, and Robert H. Mach Excerpt from the article published in Scientific Reports 8, 16845, 15 November 2018, DOI: https://doi.org/10.1038/s41598-018-35430-3 Editor’s Highlights The disruption of lipoprotein trafficking may also be responsible for the mechanism of action of sigma-2 receptors (TMEM97/σ2R) […]
Continue ReadingSmall molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer’s disease
By Bitna Yi, James J. Sahn, Pooneh Memar Ardestani, Andrew K. Evans, Luisa L. Scott, Jessica Z. Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan T. Pierce, Stephen F. Martin, and Mehrdad Shamloo Excerpt from the article published in Journal of Neurochemistry, 07 December 2016, 140: 561-575. DOI: https://doi.org/10.1111/jnc.13917 Editor’s Highlights Abstract Accumulating evidence suggests that […]
Continue ReadingAβ mediates Sigma receptor degradation via CaN/NFAT pathway
By Min Fang, Pei Zhang, Yanxin Zhao, Aiping Jin, and Xueyuan Liu Excerpt from the article published in American Journal of Translational Research 2016; 8(8): 3471–3481. Published online 2016 Aug 15. PMCID: PMC5009399 Editor’s Highlights Extracellular Aβ accumulation has been found as a major molecular mechanism underlying the pathogenesis of Alzheimer disease (AD). The abnormal Aβ accumulation may […]
Continue ReadingSoluble α-Synuclein Is a Novel Modulator of Alzheimer’s Disease Pathophysiology
By Megan E. Larson, Mathew A. Sherman, Susan Greimel, Michael Kuskowski, Julie A. Schneider, David A. Bennett, and Sylvain E. Lesné Excerpt from the article published in Journal of Neuroscience 25 July 2012, 32 (30) 10253-10266; Corrected on May 26, 2022 DOI: https://doi.org/10.1523/JNEUROSCI.0581-12.2012 Editor’s Highlights Neurodegenerative diseases share the common feature of the misfolding and aggregation of proteins that are […]
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