New insights into the genetic etiology of Alzheimer’s disease and related dementias
By Bellenguez, C., Küçükali, F., Jansen, I.E. et al. Excerpt from the article published in New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet (2022). https://doi.org/10.1038/s41588-022-01024-z Editor’s Highlights The pathway enrichment analyses removed ambiguities concerning the involvement of tau-binding proteins and APP/Aβ peptide metabolism in late-onset AD processes at a much higher level than […]
Continue ReadingActivation of the sigma-1 receptor attenuates blood–brain barrier disruption by inhibiting amyloid deposition in Alzheimer’s disease mice
By Yang An, Yue Qi, Ying Li, Zhao Li, Caiyu Yang, and Dong Jia Introduction to the article published in Neuroscience Letters, volume 774, 2022, 136528, DOI: https://doi.org/10.1016/j.neulet.2022.136528. Highlights Sig-1R agonist PRE084 treatment attenuated learning and memory deficits in AD mice. PRE084 lowed the soluble and insoluble Aβ1-40 and Aβ1-42 levels in the brain. PRE084 […]
Continue ReadingNovel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands
By Ferenc Bogár, Lívia Fül. and Botond Penke Excerpt from the article published in Biomolecules 2022, 12, 363, Published: 25 February 2022, DOI: https://doi.org/10.3390/biom12030363 Editor’s Highlights Sigma-1 Receptor is a Central Regulator of Cell Survival As Sig-1R controls ER stress and the inflammatory processes in the cells, Sig-1R agonists have been tested in preclinical studies and […]
Continue ReadingImpact of Two Neuronal Sigma‐1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1‐42‐Injected, Wild‐Type Mouse Model of AD
By Emőke Borbély, Viktória Varga, Titanilla Szögi, Ildikó Schuster, Zsolt Bozsó, Botond Penke and Lívia Fülöp Excerpt from the article published in Int. J. Mol. Sci. 2022, 23, 2514. https://doi.org/10.3390/ijms23052514 Editor’s Highlights Adult neurogenesis is essential for CNS plasticity. In early AD, neurogenic impairment can be observed, accompanied by hyperreactive astrogliosis. The highly selective S1R […]
Continue ReadingImpact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD
By Emőke Borbély, Viktória Varga, Titanilla Szögi, Ildikó Schuster, Zsolt Bozsó, Botond Penke, and Lívia Fülöp Excerpt of the article published in International Journal of Molecular Sciences 23, no. 5: 2514., 24 February 2022, DOI: https://doi.org/10.3390/ijms23052514 Editor’s Highlights In early Alzheimer’s disease (AD), neurogenic impairment can be observed, accompanied by hyperreactive astrogliosis. Neuronal sigma-1 receptors (S1Rs) […]
Continue ReadingBRD2 regulation of sigma-2 receptor upon cholesterol deprivation
By Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, and Lian-Wang GuoLife Excerpt from the article published in Science Alliance Nov 2020, 4 (1) e201900540; DOI: 10.26508/lsa.201900540 Editor’s Highlights Sigma-2 receptor is a recently unveiled player in cholesterol homeostasis. Bromodomain BRD2 and SREBP2 (sterol regulatory element-binding protein 2) cooperatively regulates S2R transcription. […]
Continue ReadingRoles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases
By Chen Q, Fang J, Shen H, et al. Excerpt from the article published in American journal of translational research vol. 13,12 13273-13297. 15 Dec. 2021 PMID: 35035675 PMCID: PMC8748174 Editor’s Highlights Transmembrane protein family members (TMEMs) are distributed in almost every organ of the body, but its expression is particularly pronounced in the brain. TMEMs play different roles […]
Continue ReadingRevisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders
by Kinga Sałaciak, Karolina Pytka Excerpt from the article published in Neuroscience & Biobehavioral Reviews Volume 132, January 2022, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2021.10.037. Editor’s Highlights Sigma-1 receptors are unique therapeutic targets modulating the activity of various proteins and systems in the organism. Preclinical studies reported that sigma-1 receptor expression correlates with the clinical manifestation of disease. […]
Continue ReadingIn vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease
by Georg Meisl, Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L. DeVos, Justin S. Sanchez, Catherine K. Xu, Karen E. Duff, Keith A. Johnson, James B. Rowe, Bradley T. Hyman, Tuomas P. J. Knowles, David Klenerman Excerpt from the article published in SCIENCE ADVANCES• 29 Oct 2021• Vol 7, Issue 44• DOI: 10.1126/sciadv.abh1448 Editor’s Highlights […]
Continue ReadingRole of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery
By Francesca Romana Buccellato, Marianna D’Anca, Chiara Fenoglio, Elio Scarpini, and Daniela Galimberti Excerpt from the article published in Antioxidants (Basel). 2021 Sep; 10(9): 1353. doi: 10.3390/antiox10091353 Editor’s Highlights In Alzheimer’s disease (AD), reactive microglia and astrocytes are associated with the amyloid plaques and respond to Aβ with the expression of pro-inflammatory cytokines. Microglia can respond to Aβ, […]
Continue Reading