Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks
By Bárbara Avelar-Pereira, Michael E. Belloy, Ruth O’Hara, and S. M. Hadi Hosseini for the Alzheimer’s Disease Neuroimaging Initiative Excerpt from the article published in Molecular Psychiatry. 20 December 2022, DOI: https://doi.org/10.1038/s41380-022-01886-z Editor’s Highlights Abstract Alzheimer’s disease (AD) is a multifactorial and heterogeneous disorder, which makes early detection a challenge. Studies have attempted to combine […]
Continue ReadingNeuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease
By Fangda Leng, Rainer Hinz, Steve Gentleman, Adam Hampshire, Melanie Dani, David J. Brooks, and Paul Edison Excerpt from the article published in Molecular Psychiatry, 06 December 2022. DOI: https://doi.org/10.1038/s41380-022-01878-z Editor’s Highlights Abstract Brain network dysfunction is increasingly recognised in Alzheimer’s disease (AD). However, the causes of brain connectivity disruption are still poorly understood. Recently, […]
Continue ReadingReduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease
By Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, and Ksenia V. Kastanenka Excerpt from the article published in Communications Biology 5, 1323, 02 December 2022. DOI: https://doi.org/10.1038/s42003-022-04268-x Editor’s Highlights Abstract Alzheimer’s disease (AD) is characterized by progressive memory loss […]
Continue ReadingPLD3 affects axonal spheroids and network defects in Alzheimer’s disease
By Peng Yuan, Mengyang Zhang, Lei Tong, Thomas M. Morse, Robert A. McDougal, Hui Ding, Diane Chan, Yifei Cai, and Jaime Grutzendler Excerpt from the article published in Nature, 30 November 2022. DOI: https://doi.org/10.1038/s41586-022-05491-6 Editor’s Highlights Abstract The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal […]
Continue ReadingMitochondrial Ca2+ Signaling and Bioenergetics in Alzheimer’s Disease
By Nikita Arnst, Nelly Redolfi, Annamaria Lia, Martina Bedetta, Elisa Greotti, and Paola Pizzo Excerpt from the article Biomedicines 10, no. 12: 3025. 24 November 2022. DOI: https://doi.org/10.3390/biomedicines10123025 Editor’s Highlights Abstract Alzheimer’s disease (AD) is a hereditary and sporadic neurodegenerative illness defined by the gradual and cumulative loss of neurons in specific brain areas. The processes […]
Continue ReadingApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
By Ana-Caroline Raulin, Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu, and Chia-Chen Liu Excerpt from the article published in Molecular Neurodegeneration 17, 72, 8 November 2022, DOI: https://doi.org/10.1186/s13024-022-00574-4 Editor’s Highlights Abstract Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. […]
Continue ReadingAmyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease
By Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, and Oskar Hansson Excerpt from the article published in Nature Communications 13, 6635, 04 November 2022. DOI: https://doi.org/10.1038/s41467-022-34129-4 Editor’s Highlights Abstract For optimal design of anti-amyloid-β (Aβ) […]
Continue ReadingThe synergy of β amyloid 1-42 and oxidative stress in the development of Alzheimer’s disease-like neurodegeneration of hippocampal cells
By Gohar Karapetyan, Katarine Fereshetyan, Hayk Harutyunyan, and Konstantin Yenkoyan Excerpt from the article published in Scientific Reports 12, 17883, 25 October 2022. DOI: https://doi.org/10.1038/s41598-022-22761-5 Editor’s Highlights Alzheimer’s disease (AD) is a neurodegenerative disease that occurs in elderly individuals and which incidence has increased year by year, and there is still no effective drug for treating […]
Continue ReadingProtein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction
By Laura Tapella, Giulia Dematteis, Marianna Moro, Beatrice Pistolato, Elisa Tonelli, Virginia Vita Vanella, Daniele Giustina, Aleida La Forgia, Elena Restelli, Elettra Barberis, Tito Cali, Marisa Brini, Salvatore Villani, Erika Del Grosso, Mariagrazia Grilli, Marcello Manfredi, Marco Corazzari, Ambra A. Grolla, Armando A. Genazzani, and Dmitry Lim Excerpt from the article published in Cell Death […]
Continue ReadingClinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer’s disease
By Ibtisam Mumtaz, Mir Owais Ayaz, Mohamad Sultan Khan, Umar Manzoor, Mohd Azhardin Ganayee, Aadil Qadir Bhat, Ghulam Hassan Dar, Badrah S. Alghamdi, Anwar M. Hashem, Mohd Jamal Dar, Gulam Md. Ashraf, and Tariq Maqbool Excerpt from the article published in Frontiers in Aging Neuroscience, 07 September 2022, Sec. Alzheimer’s Disease and Related Dementias, DOI: […]
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