Sigma 1 receptor - Advantx Pharmaceuticals Inc.

Dysregulated Ca2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer’s Disease and Wolfram Syndrome

By Manon Callens, Jens Loncke, and Geert Bultynck Excerpt from the article published in Cells 2022, 11, 1963. DOI: https://doi.org/10.3390/cells11121963 Editor’s Highlights Abstract Calcium ions (Ca2+) operate as important messengers in the cell, indispensable for signaling the underlying numerous cellular processes in all of the cell types in the human body. In neurons, Ca2+ signaling is crucial for […]

A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders

By Jessica Proulx, Satomi Stacy, In-Woo Park, and Kathleen Borgmann Excerpt from the article published in Frontiers in Neuroscience, 16, 17 June 2022, DOI https://doi.org/10.3389/fnins.2022.906651 Editor’s Highlights During human immunodeficiency virus (HIV)-1 infection or (METH)amphetamine exposure, astrocytes shift their neuroprotective functions and can become neurotoxic. As common comorbidity among HIV-1 infected individuals (METH)amphetamine use can […]

Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development

By Peng Ren, Jingya Wang, Nanxi Li, Guangxiang Li, Hui Ma, Yongqi Zhao, and Yunfeng Li Excerpt from the article published in Frontiers on Pharmacology, 16 June 2022, Sec.Neuropharmacology, DOI: https://doi.org/10.3389/fphar.2022.925879 Editor’s Highlights Depression is a mainly persistent mood disorder that negatively impacts the social, vocational and educational aspects of people’s life. Sigma-1 receptors are […]

Molecular function of Sigma-1 receptor in obesity-induced metabolic dysfunction

By Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Jonette M. Green, A. Wayne Orr, Matthew D. Woolard, Aimee E. Vozelinek, Norman R. Harris, Randa S. Eshaq, Christopher G. Kevil, and Shenuarin Bhuiyan Introduction to the article published in Journal of Molecular and Cellular Cardiology, 046| VOLUME 112, P149, NOVEMBER 01, 2017, DOI: https://doi.org/10.1016/j.yjmcc.2017.07.058 Editor’s Highlights Sigma-1 receptor (Sigmar1) […]

Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2

By Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, and Fengdong Zhao Excerpt from the article published in EMBO Molecular Medicine e15373 25 May 2022 DOI: https://doi.org/10.15252/emmm.202115373 Editor’s Highlights Abstract Sigma-1 receptor (Sigmar1) is a […]

Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

By Zonghan Liu, Yi Sun, Zhengtang Qi, Lu Cao, and Shuzhe Ding Excerpt from the article published in Cell and Bioscience 12, 66 (2022). Published: 19 May 2022, DOI: https://doi.org/10.1186/s13578-022-00805-7 Editor’s Highlights Mitochondria are semiautonomous, semiself-replicating, highly dynamic organelles, endowed with their own circular, double-stranded DNA molecule that spans 16.6 kb and intramitochondrial replication and translational machinery. Intercellular mitochondrial […]

Intracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy

By Sergei Kopanchuk, Edijs Vavers , Santa Veiksina, Kadri Ligi, Liga Zvejniece, Maija Dambrova, and Ago Rinken Excerpt from the article published in PLoS ONE 17(5): e0268563. May 18, 2022, DOI: https://doi.org/10.1371/journal.pone.0268563 Editor’s Highlights The sigma-1 receptor (Sig1R) has been described as an intracellular protein modulator, a chaperone protein that localizes in the endoplasmic reticulum […]

Cellular interorganelle crosstalk in health and disease states: A glimpse on nephrology-related conditions

By Fateme Shamekhi Amiri Excerpt from the article published in Archives of Clinical Nephrology 8(1): 007-027. DOI: 10.17352/acn.000059 Editor’s Highlights Mitochondria as a signalling organelle associates with the cellular signalling environment and mediates gene expression programs. Mitochondria are constantly interacting with other organelles through signalling pathways, and on some occasions even though physical contact sites. Sigma-1receptor […]

Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension

By Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang & Bo Yang (2022) Excerpt from the article published in Bioengineered, 13:4, 10843-10856, DOI: 10.1080/21655979.2022.2065953 Editor’s Highlights Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive elevation in mean pulmonary artery pressure, which […]

Effects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats

By Sándor Váczi, Lilla Barna, Krisztián Laczi, Ferenc Tömösi, Gábor Rákhely, Botond Penke, Lívia Fülöp, Ferenc Bogár, Tamás Janáky, Mária A. Deli, and Zsófia Mezei Excerpt from the article published in European Journal of Pharmacology, 2022, 174983 Doi: https://doi.org/10.1016/j.ejphar.2022.174983. Editor’s Highlights Only a fraction of all cardiovascular diseases is of cardiac origin, and macro-and microvascular […]

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