Sigma 1 receptor - Advantx Pharmaceuticals Inc.

Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain

By Mireia Carcolé, Daniel Zamanillo, Manuel Merlos, Begoña Fernández-Pastor, David Cabañero, and Rafael Maldonado Excerpt from the article published in Frontiers in Pharmacology, 03 May 2019Sec. Experimental Pharmacology and Drug Discovery DOI: https://doi.org/10.3389/fphar.2019.00468 Abstract Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, […]

Molecular Interplay Between the Sigma-1 Receptor, Steroids, and Ion Channels

By Sara L. Morales-Lázaro, Ricardo González-Ramírez, and Tamara Rosenbaum Excerpt from the article published in Frontiers in Pharmacology, 10.,24 April 2019Sec. Experimental Pharmacology and Drug Discovery, DOI: https://doi.org/10.3389/fphar.2019.00419 Editor’s Highlights Abstract Cell excitability is tightly regulated by the activity of ion channels that allow for the passage of ions across cell membranes. Ion channel activity is […]

Modulation of the Sigma-1 Receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.

By Dorian A Rosen, Scott M. Seki, Anthony Fernández-Castañeda, Rebecca M. Beiter, Jacob D. Eccles, Judith A. Woodfolk, and Alban Gaultier Excerpt from the author manuscript published in Science translational medicine, 2019 Feb 6; 11(478): eaau5266. available here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936250/#!po=28.9474 Editor’s Highlights The endoplasmic reticulum (ER) is increasingly recognized as a powerful controller of inflammatory signaling and […]

SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance

By Huan Yang, Hongtao Shen, Jing Li, and Lian-Wang Guo Excerpt from the article published in Autophagy, 15:9, 1539-1557, Published online: 14 Mar 2019 DOI: 10.1080/15548627.2019.1586248 Editor’s Highlights Autophagy lysosome-mediated pathway (ALP) degrades and recycles cellular wastes including proteins, lipids, and dysfunctional organelles, and is a key element of the Proteostasis Network. SIGMAR1 is a putative chaperone protein primarily […]

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

By Maximilian G. Christ, Heike Huesmann, Heike Nagel, Andreas Kern and Christian Behl Excerpt from the article published in Cells. 2019; 8(3):211. DOI: https://doi.org/10.3390/cells8030211 Editor’s Highlights The control and maintenance of proteome integrity and proteostasis are of utmost importance. Cellular proteostasis includes protein folding, protein assembly, refolding of damaged proteins, as well as protein degradation, […]

Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics

By Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Mohammad Alfrad Nobel Bhuiyan, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Hanna Osinska, Jeffrey Robbins, John N. Lorenz, and Md. Shenuarin Bhuiyan Excerpt from the article published in Journal of the American Heart Association. 2018;7:e009775, 11 Oct 2018, DOI: https://doi.org/10.1161/JAHA.118.009775 Editor’s Highlights […]

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1

By Christina M. Maher; Jeffrey D. Thomas; Derick A. Haas; Charles G. Longen; Halley M. Oyer; Jane Y. Tong; and Felix J. Kim Excerpt from the article published in Molecular Cancer Research, Volume 16, Issue 2; 1 February 2018; 243–255; DOI: https://doi.org/10.1158/1541-7786.MCR-17-0166 Editor’s Highlights Abstract Emerging evidence suggests that Sigma1 (SIGMAR1, also known as sigma-1 […]

TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain

By Miguel Ortíz-Rentería, Rebeca Juárez-Contreras, Ricardo González-Ramírez, and Sara L. Morales-Lázaro Excerpt from the article published in PNAS, January 29, 2018, 115 (7) E1657-E1666, DOI: https://doi.org/10.1073/pnas.1715972115 Significance The TRPV1 ion channel has been widely associated with the generation of painful responses. The responses of cells expressing this ion channel and, presumably, the overall pain response of an […]

Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases

By Tzu-Yu Weng, Shang-Yi Anne Tsai, and Tsung-Ping Su Excerpt from the article published in Journal of Biomedical Science 24, 74 (2017). https://doi.org/10.1186/s12929-017-0380-6 Editor’s highlights The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. The Sig-1R […]

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

By Jing Zhao, Barbara A. Mysona, Jing Wang, Graydon B. Gonsalvez, Sylvia B. Smith, and Kathryn E. Bollinger Excerpt from the article published in PLOS ONE, September 12, 2017, DOI: https://doi.org/10.1371/journal.pone.0184421 Editor’s Highlights Neuronal and glial cell types throughout the retina and optic nerve contain sigma 1 receptor (S1R), and its agonists display robust neuroprotective […]

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