Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
By Dicson S. Malar, Premrutai Thitilertdecha, Kanokphorn S. Ruckvongacheep, Sirikalaya Brimson, Tewin Tencomnao, and James M. Brimson Excerpt from the article published in CNS Drugs, May 2023. DOI: https://doi.org/10.1007/s40263-023-01007-6 Editor’s Highlights Abstract The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a genetically unrelated protein with […]
Continue ReadingSIGMAR1 Confers Innate Resilience against Neurodegeneration
By Simon Couly, Yuko Yasui, and Tsung-Ping Su Excerpt from the article published in the International Journal of Molecular Sciences 24, no. 9: 7767. 24 April 2023, DOI: https://doi.org/10.3390/ijms24097767 Abstract The sigma-1 receptor (SIGMAR1) is one of a kind: a receptor chaperone protein. This 223 amino acid-long protein is enriched at the mitochondria-associated endoplasmic reticulum membrane […]
Continue ReadingInvestigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands
By Gianmarco Pascarella, Lorenzo Antonelli, Daniele Narzi, Theo Battista, Annarita Fiorillo, Gianni Colotti, Leonardo Guidoni, Veronica Morea, and Andrea Ilari Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6367. 28 March 2023. DOI: https://doi.org/10.3390/ijms24076367 Editor’s Highlights Abstract The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in […]
Continue ReadingSigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
By Bashar M. Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca S. Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H. Mach, Nunzio Denora, Byung Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, and Michael A. Cahill Excerpt from the article published in the International Journal of Molecular […]
Continue ReadingSigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases
By Britney N. Lizama, Jennifer Kahle, Susan M. Catalano, Anthony O. Caggiano, Michael Grundman, and Mary E. Hamby Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6251. 26 March 2023. DOI: https://doi.org/10.3390/ijms24076251 Editor’s Highlights Abstract There is a large unmet medical need to develop disease-modifying treatment options for individuals with age-related […]
Continue ReadingThe Sigma Enigma: A Narrative Review of Sigma Receptors
By Joseph Pergolizzi, Giustino Varrassi, Mark Coleman, Frank Breve, Dana K. Christo, Paul J. Christo, and Charbel Moussa Excerpt from the article published in Cureus 15(3): e35756. March 04, 2023; doi: 10.7759/cureus.35756 Abstract The sigma-1 and sigma-2 receptors were first discovered in the 1960s and were thought to be a form of opioid receptors initially. […]
Continue ReadingSphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N’-Dimethylsphingosine Are Endogenous Agonists
By Jing Li, Kenneth A. Satyshur, Lian-Wang Guo, and Arnold E. Ruoho Excerpt from the article published in the International Journal of Molecular Sciences. 2023; 24(4):3103; 4 February 2023, DOI: https://doi.org/10.3390/ijms24043103 Editor’s Highlights Abstract Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are […]
Continue ReadingOverview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection
By Véronik Lachance, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, and Saïd Kourrich Excerpt from the article published in the International Journal of Molecular Sciences. 19 January 2023; 24(3):1971. DOI: https://doi.org/10.3390/ijms24031971 Editor’s Highlights Abstract For the past several years, fundamental research on Sigma-1R (S1R) […]
Continue ReadingChaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection
By Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 24, no. 1: 823. 3 January 2023, DOI: https://doi.org/10.3390/ijms24010823 Editor’s Highlights Abstract Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease […]
Continue ReadingSigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke
By Gufang Zhang, Qi Li, Weijie Tao, Pingping Qin, Jiali Chen, Huicui Yang, Jiaojiao Chen, Hua Liu, Qijun Dai, and Xuechu Zhen Excerpt from the article published in Theranostics. 2023 Jan 1;13(2):543-559. DOI: 10.7150/thno.77088. PMID: 36632219; PMCID: PMC9830433. Editor’s Highlights Abstract Background: Efferocytosis of apoptotic neurons by macrophages is essential for the resolution of inflammation and […]
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