Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
By Bashar M. Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca S. Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H. Mach, Nunzio Denora, Byung Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, and Michael A. Cahill Excerpt from the article published in the International Journal of Molecular […]
Continue ReadingSigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
By Remex Naznin Sultana, Abdullah Chowdhury S., Aishwarya Richa, Nitu Sadia S., Traylor James, Hartman Brandon, King Judy, Bhuiyan Mohammad Alfrad Nobel, Kevil Christopher G., Orr A. Wayne, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 14, 27 March 2023Sec. Respiratory Physiology and Pathophysiology, ISSN 1664-042X, DOI: 10.3389/fphys.2023.1118770 Editor’s […]
Continue ReadingSigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases
By Britney N. Lizama, Jennifer Kahle, Susan M. Catalano, Anthony O. Caggiano, Michael Grundman, and Mary E. Hamby Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6251. 26 March 2023. DOI: https://doi.org/10.3390/ijms24076251 Editor’s Highlights Abstract There is a large unmet medical need to develop disease-modifying treatment options for individuals with age-related […]
Continue ReadingThe Sigma Enigma: A Narrative Review of Sigma Receptors
By Joseph Pergolizzi, Giustino Varrassi, Mark Coleman, Frank Breve, Dana K. Christo, Paul J. Christo, and Charbel Moussa Excerpt from the article published in Cureus 15(3): e35756. March 04, 2023; doi: 10.7759/cureus.35756 Abstract The sigma-1 and sigma-2 receptors were first discovered in the 1960s and were thought to be a form of opioid receptors initially. […]
Continue ReadingGender and Neurosteroids: Implications for Brain Function, Neuroplasticity, and Rehabilitation
By Loredana Raciti, Caterina Formica, Gianfranco Raciti, Angelo Quartarone, and Rocco Salvatore Calabrò Excerpt from the article published in the International Journal of Molecular Sciences. 2023; 24(5):4758. 1 March 2023. DOI: https://doi.org/10.3390/ijms24054758 Editor’s Highlights Abstract Neurosteroids are synthesized de novo in the nervous system; they mainly moderate neuronal excitability, and reach target cells via the […]
Continue ReadingPotential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis
By Yu-Mi Jeon, Younghwi Kwon, Shinrye Lee, and Hyung-Jun Kim Excerpt from the article published in Frontiers in Aging Neuroscience, 15 February 2023. DOI: https://doi.org/10.3389/fnagi.2023.1047897 Editor’s Highlights Abstract The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and cellular homeostasis. ER stress results from structural and functional dysfunction of the organelle, along […]
Continue ReadingSigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function
By Alba Vera-Zambrano, Maria Baena-Nuevo, Susanne Rinné, Marta Villegas-Esguevillas, Bianca Barreira, Gokcen Telli, Angela de Benito-Bueno, José Antonio Blázquez, Belén Climent, Francisco Pérez-Vizcaino, Carmen Valenzuela, Niels Decher, Teresa Gonzalez, and Angel Cogolludo Excerpt from the article published in Pharmacological Research, Volume 189, March 2023, 106684,ISSN 1043-6618, DOI: https://doi.org/10.1016/j.phrs.2023.106684. Editor’s Highlights Abstract KV1.5 channels are key […]
Continue ReadingDevelopment of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes
By Jiang-Hui Wang, Daniel Urrutia-Cabrera, Jarmon G. Lees, Santiago Mesa Mora, Tu Nguyen, Sandy S. C. Hung, Alex W. Hewitt, Shiang Y. Lim, Thomas L. Edwards, and Raymond C. B. Wong Excerpt from the article published in the International Journal of Molecular Sciences. 8 February 2023; 24(4):3417. DOI: https://doi.org/10.3390/ijms24043417 Editor’s Highlights Abstract Age-related macular degeneration […]
Continue ReadingSphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N’-Dimethylsphingosine Are Endogenous Agonists
By Jing Li, Kenneth A. Satyshur, Lian-Wang Guo, and Arnold E. Ruoho Excerpt from the article published in the International Journal of Molecular Sciences. 2023; 24(4):3103; 4 February 2023, DOI: https://doi.org/10.3390/ijms24043103 Editor’s Highlights Abstract Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are […]
Continue ReadingSSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids
By Yukitoshi Izumi, Angela M. Reiersen, Eric J. Lenze, Steven J. Mennerick, and Charles F. Zorumski Excerpt from the article published in Translational Psychiatry 13, 39, 03 February 2023, DOI: https://doi.org/10.1038/s41398-023-02343-3 Editor’s Highlights Abstract Certain selective serotonin reuptake inhibitors (SSRIs) have anti-inflammatory effects in preclinical models, and recent clinical studies suggest that fluvoxamine can prevent deterioration […]
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