Sigma 1 receptor activation improves retinal structure and function in the RhoP23H/+ mouse model of autosomal dominant retinitis pigmentosa
By Shannon R. Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, and Sylvia B. Smith Extract from the article published in Experimental Eye Research, Volume 230, May 2023, 109462, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2023.109462 Editor’s Highlights Abstract Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to visual impairment and oftentimes complete blindness. Currently no […]
Continue ReadingSigma-1 receptor and seizures
By Edijs Vavers, Liga Zvejniece, and Maija Dambrova Excerpt from the article published in Pharmacological Research, Volume 191, May 2023, 106771, ISSN 1043-6618, DOI: https://doi.org/10.1016/j.phrs.2023.106771. Editor’s Highlights Abstract Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R […]
Continue ReadingSIGMAR1 Confers Innate Resilience against Neurodegeneration
By Simon Couly, Yuko Yasui, and Tsung-Ping Su Excerpt from the article published in the International Journal of Molecular Sciences 24, no. 9: 7767. 24 April 2023, DOI: https://doi.org/10.3390/ijms24097767 Abstract The sigma-1 receptor (SIGMAR1) is one of a kind: a receptor chaperone protein. This 223 amino acid-long protein is enriched at the mitochondria-associated endoplasmic reticulum membrane […]
Continue ReadingSchizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment
By Giuseppe De Simone, Benedetta Mazza, Licia Vellucci, Annarita Barone, Mariateresa Ciccarelli, and Andrea de Bartolomeis Excerpt from the article published in Antioxidants 12, 21 April 2023, no. 4: 975. DOI: https://doi.org/10.3390/antiox12040975 Editor’s Highlights Abstract Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic and glutamatergic synapses resulting in global dysconnectivity within and between […]
Continue ReadingEvaluation of Some Safety Parameters of Dual Histamine H3 and Sigma-2 Receptor Ligands with Anti-Obesity Potential
By Kamil Mika, Małgorzata Szafarz, Marek Bednarski, Agata Siwek, Katarzyna Szczepańska, Katarzyna Kieć-Kononowicz, and Magdalena Kotańska Excerpt from the article published in the International Journal of Molecular Sciences 24, 19 April 2023, no. 8: 7499. DOI: https://doi.org/10.3390/ijms24087499 Editor’s Highlights Abstract Many studies have shown the high efficacy of histamine H3 receptor ligands in preventing weight gain. In addition […]
Continue ReadingAutophagy and Breast Cancer: Connected in Growth, Progression, and Therapy
By Qitong Wu and Dipali Sharma Excerpt from the article published in Cells. 14 April 2023; 12(8):1156. DOI: https://doi.org/10.3390/cells12081156 Editor’s Highlights Abstract Despite an increase in the incidence of breast cancer worldwide, overall prognosis has been consistently improving owing to the development of multiple targeted therapies and novel combination regimens including endocrine therapies, aromatase inhibitors, […]
Continue ReadingValidation of σ2R/TMEM97 as a neuropathic pain target: Specificity, human expression and mechanism of action
By Muhammad Saad Yousuf, James J. Sahn, Eric T. David, Stephanie Shiers, Danielle M. Royer, Chelsea D. Garcia, Jennifer Zhang, Veronica M. Hong, Ayesha Ahmad, Benedict J. Kolber, Daniel J Liebl, Stephen F. Martin, and Theodore J. Price Excerpt from the article published in bioRxiv 2023.04.11., 536439; DOI: https://doi.org/10.1101/2023.04.11.536439 Editor’s Highlights Abstract The Sigma 2 receptor (σ2R) […]
Continue ReadingGut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway
By Jia-Hao Li, Jia-Li Liu, Xiu-Wen Li, Yi Liu, Jian-Zheng Yang, Li-Jian Chen, Kai-Kai Zhang, Xiao-Li Xie, and Qi Wang Excerpt from the article published in Frontiers in Microbiology, 06 April 2023, Sec. Evolutionary and Genomic Microbiology, Volume 14 – 2023, DOI: https://doi.org/10.3389/fmicb.2023.1143648 Editor’s Highlights Abstract Introduction: Depression is a common mental disorder that affects approximately 350 […]
Continue ReadingEarly Alterations of RNA Binding Protein (RBP) Homeostasis and ER Stress-Mediated Autophagy Contributes to Progressive Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa (RP)
By Alfred Yamoah, Priyanka Tripathi, Haihong Guo, Leonie Scheve, Peter Walter, Sandra Johnen, Frank Müller, Joachim Weis, and Anand Goswami Excerpt from the article published in Cells. 6 April 2023; 12(7):1094. DOI: https://doi.org/10.3390/cells12071094 Editor’s Highlights Abstract The retinal degeneration 10 (rd10) mouse model is widely used to study retinitis pigmentosa (RP) pathomechanisms. It offers a […]
Continue ReadingInvestigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands
By Gianmarco Pascarella, Lorenzo Antonelli, Daniele Narzi, Theo Battista, Annarita Fiorillo, Gianni Colotti, Leonardo Guidoni, Veronica Morea, and Andrea Ilari Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6367. 28 March 2023. DOI: https://doi.org/10.3390/ijms24076367 Editor’s Highlights Abstract The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in […]
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