More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation
By Esperanza Mata-Martínez, Claudia Sánchez-Cárdenas, Julio C. Chávez, Adán Guerrero, Claudia L. Treviño, Gabriel Corkidi, Fernando Montoya, Paul Hernandez-Herrera, Mariano G. Buffone, Paula A. Balestrini, and Alberto Darszon. Excerpt from the article published in Biosystems 209, pages 104524 (2021). Doi: https://doi.org/10.1080/19336950.2021.1900024 Editor’s Highlights The diversity of calcium channel phenotypes is strongly increased by the association of the auxiliary subunits β, α2δ, and γ as well as many other […]
Continue Readingσ2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
By Francesca Serena Abatematteo, Mauro Niso, Enza Lacivita, and Carmen Abate Excerpt from the article published in Molecules. 2021;26(12):3743. Published 2021 Jun 19. DOI: https://doi.org/10.3390/molecules26123743 Editor’s Highlights The role in the proliferative status of cells has directed the σ2-related scientific interest towards cancer research. The σ2 receptor modulates ER stress [74], likely through control of Ca2+ release […]
Continue ReadingThe Role of Astrocytes in the Neurorepair Process
By Raphaela Almeida Chiareli, Gustavo Almeida Carvalho, Bruno Lemes Marques, Lennia Soares Mota, Onésia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Alexander Birbrair, Renato Santiago Gomez, Fabrício Simão, Friederike Klempin, Marcel Leist, and Mauro Cunha Xavier Pinto Excerpt from the article published in Frontiers in Cell and Developmental Biology, 25 May 2021 | https://doi.org/10.3389/fcell.2021.665795 Editor’s Highlights Astrocytes […]
Continue ReadingInvolvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole
By Mikhail V. Voronin, Yulia V. Vakhitova, Inna P. Tsypysheva, Dmitry O. Tsypyshev, Inna V. Rybina, Rustam D. Kurbanov, Elena V. Abramova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 22, no. 11: 5455. https://doi.org/10.3390/ijms22115455 Editor’s Highlights Epidemiological data indicate that the global prevalence of anxiety disorders reaches 7.3%. […]
Continue ReadingAxonal generation of amyloid-b from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
By Raja Bhattacharyya, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn, Mehdi Jorfi, Dora M. Kovacs, Rudolph E. Tanzi Excerpt from the article published in Cell Rep. May 18, 2021 DOI: https://doi.org/10.1016/j.celrep.2021.109134 Editor’s Highlights Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology To transport proteins to the cell […]
Continue ReadingThe role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
By Vladimir Zhemkov, Jonathon A Ditlev, Wan-Ru Lee, Mikaela Wilson, Jen Liou, Michael K Rosen, Ilya Bezprozvanny Excerpt from the article published in eLife 2021;10:e65192 DOI: 10.7554/eLife.65192 Editor’s Highlights Sigma-1 receptor (S1R) modulates many physiological processes, such as cell excitability, transcriptional activity, Ca2+ homeostasis, stress response, and autophagy. Many biological functions of the Sigma-1 receptor can be explained […]
Continue ReadingCrystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo
By Assaf Alon, Jiankun Lyu, Joao M. Braz, Tia A. Tummino, Veronica Craik, Matthew J.O’Meara, Chase M. Webb, Dmytro S. Radchenko, Yurii S. Moroz, Xi-Ping Huang, Yongfeng Liu, Bryan L. Roth, John J. Irwin, Allan I. Basbaum, Brian K. Shoichet, and Andrew C. Kruse Excerpt from the article published in bioRxiv 2021.04.29.441652; April 30, 2021; DOI: https://doi.org/10.1101/2021.04.29.441652 Editor’s Highlights Abstract The σ2 receptor is a poorly understood transmembrane receptor that has attracted intense interest in many areas of biology including cancer imaging, Alzheimer’s disease, schizophrenia, and neuropathic pain. However, […]
Continue ReadingSigma-1 Receptor Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases
by Zhemkov V, Geva M, Hayden MR, Bezprozvanny I Excerpt from the article published in Int J Mol Sci. 2021;22(8):4082. Published 2021 Apr 15. https://doi.org/10.3390/ijms22084082 Editor’s Highlights The Sigma-1 receptor (S1R) is a well-established target for the treatment of neurodegenerative disorders, and it plays a key role in neurodegenerative diseases. Some variants of the S1R […]
Continue ReadingThe ER protein Ema19 [tmem97] facilitates the degradation of nonimported mitochondrial precursor proteins
![The ER protein Ema19 [tmem97] facilitates the degradation of nonimported mitochondrial precursor proteins](https://advantx.org/wp-content/uploads/2016/11/slide-2-1100x550.jpg)
By Janina Laborenz, Yury S. Bykov, Katharina Knöringer, Markus Räschle, Sabine Filker, Cristina Prescianotto-Baschong, Anne Spang, Takashi Tatsuta, Thomas Langer, Zuzana Storchová, Maya Schuldiner, and Johannes M. Herrmann Excerpt from the article published on Molecular Biology of the Cell, Volume 32, Issue 8, Published Online: 13 Apr 2021, DOI: https://doi.org/10.1091/mbc.E20-11-0748 Editor’s Highlights Ema19 is the […]
Continue ReadingInterorganelle communication, aging, and neurodegeneration
By Maja Petkovic, Caitlin E. O’Brien, and Yuh Nung Jan Excerpt from the article published in Genes & Dev. 2021. 35: 449-469 PMCID: PMC8015714 DOI: 10.1101/gad.346759.120 Editor’s Highlights Cellular organelles and their associated processes do not function in isolation, but within a robust cellular communication network—the cellular communicome—to maintain homeostasis. Many proteins participate at multiple distinct contact sites between different […]
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