Scientific Papers - Advantx Pharmaceuticals Inc.

Histatin-1 is an endogenous ligand of the sigma-2 receptor

By Kyung-No Son, Hyun Lee, Dhara Shah, Sushma Kalmodia, Ryan Cree Miller, Marwan Ali, Arun Balasubramaniam, Stephanie M. Cologna, Hyunjoon Kong, Deepak Shukla, and Vinay Kumar Aakalu Excerpt from the manuscript published in final edited form in FEBS J. 2021 Jul 7 : 10.1111/febs.16108. DOI: 10.1111/febs.16108 Editor’s Highlights The Sigma-2 receptor (S2R) was recently identified as the […]

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

By Aishwarya Richa, Abdullah Chowdhury S., Morshed Mahboob, Remex Naznin Sultana, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 12, 2021. DOI: https://doi.org/10.3389/fphys.2021.705575 Editor’s Highlights Sigma-1 receptor is a multifunctional, ubiquitously expressed chaperone protein encoded by the SIGMAR1 gene. Alterations in Sigmar1’s subcellular localization, expression, and signaling have been […]

Astrocyte-Neuron Signaling in Synaptogenesis

By Lili Shan, Tongran Zhang, Kevin Fan, Weibo Cai, and Huisheng Liu Excerpt from the article published in Frontiers in Cell and Developmental Biology 2021; 9: 680301, 2021 Jul 2. doi: 10.3389/fcell.2021.680301 Editor’s Highlights Synapses are the fundamental units in building the entire neural network, through which signals are transferred from pre-synaptic neurons to post-synaptic cells in a […]

Sigmar1 in lipid metabolism

By Shenuarin Bhuiyan A study funded by the National Institute of Health (NIH). 2021 Editor’s Highlights The molecular function of Sigma-1 receptor (Sigmar1) proteins in metabolism is associated with lipid-containing micro-domains suggesting a potential role in the pathophysiology of metabolic diseases. This study will investigate a novel function for Sigmar1 in regulating lipid metabolism in […]

Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging

By Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa, Seigo Kinuya Excerpt from the article published in Circulation Journal, Article ID CJ-21-0320, Online ISSN 1347-4820, Print ISSN 1346-9843, DOI: https://doi.org/10.1253/circj.CJ-21-0320 Editor’s Highlights The sigma-1 receptor chaperone (σ1R) is considered as a pluripotent modulator with resultant multiple functional manifestations in […]

Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress

By Koshenov, Z.; Oflaz, F.E.; Hirtl, M.; Pilic, J.; Bachkoenig, O.A.; Gottschalk, B.; Madreiter-Sokolowski, C.T.; Rost, R.; Malli, R.; Graier, W.F. Excerpt from the article published in Metabolites 2021, 11, 422. Published: 26 June 2021, DOI: https://doi.org/10.3390/metabo11070422 Editor’s Highlights The endoplasmic reticulum (ER) is a complex, multifunctional organelle of eukaryotic cells and responsible for the trafficking and […]

Bifunctional μ opioid and σ1 receptor ligands as novel analgesics with reduced side effects

By Tao Zhuang, Jiaying Xiong, Shuaishuai Hao, Wei Du, Zhenming Liu, Bifeng Liu, Guisen Zhang, and Yin Chen Introduction to the article published in European Journal of Medicinal Chemistry, Volume 223, 2021. Doi: https://doi.org/10.1016/j.ejmech.2021.113658 Editor’s Highlights Pain is undoubtedly both a major clinical and economic problem, affecting approximately 20% of the adult population worldwide. There […]

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis

By Shohei Sakai, Seiji Watanabe, Okiru Komine, Akira Sobue, and Koji Yamanaka Excerpt from the article published in The FASEB Journal. 2021; 35:e21688. pPublished: 18 June 2021, DOI: https://doi.org/10.1096/fj.202100137R Editor’s Highlights Aberrant regulation of MAM is associated with various neurological diseases, including amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that selectively affects motor neurons. MAM disruption is […]

Involvement of Sigma Receptor-1 in Lymphatic Endothelial Barrier Integrity and Bioenergetic Regulation

By Zeinab Y. Motawe, Salma S. Abdelmaboud, and Jerome W. Breslin Excerpt from the article published in Lymphatic Research and Biology.Jun 2021.231-239. http://doi.org/10.1089/lrb.2020.0060 Editor’s Highlights The lymphatic system has an important role in fluid homeostasis, lymph transport, lipid trafficking, and immunity. Lymphatic function starts in the vast networks of lymphatic capillaries (also termed initial lymphatic […]

The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation

By Dominique Fernández, Antonia Geisse, Jose Ignacio Bernales, Alonso Lira, and Fabiola Osorio Excerpt from the article published in Frontiers of Aging Neuroscience, 11 June 2021, Sec. Cellular and Molecular Mechanisms of Brain-aging, DOI: https://doi.org/10.3389/fnagi.2021.682633 Editor’s Highlights Cells possess regulatory mechanisms that maintain proteostasis in conditions that overload the folding capacity of the organelle (a […]

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