Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models
By Mauro Niso, Joanna Kopecka, Francesca Serena Abatematteo, Francesco Berardi, Chiara Riganti, and Carmen Abate Excerpt from the article published in Cellular Oncology 44, 1307–1323 (2021). https://doi.org/10.1007/s13402-021-00638-5 Editor’s Highlights Pancreatic cancer is one of the most aggressive forms of cancer characterized by a poor prognosis and a five-year survival rate of ~ 8 %. Surgery represents the […]
Continue ReadingSigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection
by Mingmei Wang, Chunlei Wan, Tao He, Chaojun Han, Kailian Zhu, John L.Waddington, Xuechu Zhen Excerpt from the article published in Neuropharmacology, 15 September 2021 | https://doi.org/10.1016/j.neuropharm.2020.108360 Editor’s Highlights Abstract Mitochondria are essential for neuronal survival and function, and mitochondrial dysfunction plays a critical role in the pathological development of Parkinson’s disease (PD). Mitochondrial quality control […]
Continue ReadingRole of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery
By Francesca Romana Buccellato, Marianna D’Anca, Chiara Fenoglio, Elio Scarpini, and Daniela Galimberti Excerpt from the article published in Antioxidants (Basel). 2021 Sep; 10(9): 1353. doi: 10.3390/antiox10091353 Editor’s Highlights In Alzheimer’s disease (AD), reactive microglia and astrocytes are associated with the amyloid plaques and respond to Aβ with the expression of pro-inflammatory cytokines. Microglia can respond to Aβ, […]
Continue ReadingSigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma
By Linya Li, Shaoqing He, Yang Liu, Thomas Yorio, Dorette Z. Ellis Excerpt from the article published in Investigative Ophthalmology & Visual Science August 2021, Vol.62, 17. doi: https://doi.org/10.1167/iovs.62.10.17 Editor’s Highlights Degeneration of the retinal ganglion cells (RGCs), their axons, and optic nerves (ONs) are hallmarks in glaucoma. The Sigma-1R (σ-1r) is localized at the endoplasmic […]
Continue ReadingGRP78 Overexpression Triggers PINK1-IP3R-Mediated Neuroprotective Mitophagy
By Tatiana Leiva-Rodríguez, David Romeo-Guitart, Mireia Herrando-Grabulosa, Pau Muñoz-Guardiola, Miriam Polo, Celia Bañuls Valerie Petegnief, Assumpció Bosch, Jose Miguel Lizcano, Nadezda Apostolova, Joaquim Forés, and Caty Casas Excerpt from the article published in Biomedicines 2021, 9, 1039. Published: 18 August 2021, DOI: https://doi.org/10.3390/biomedicines9081039 Editor’s Highlights GRP78, also known as BiP or heat shock protein 5a (HSP5a), is […]
Continue ReadingSigma receptors and neurological disorders
By Agnieszka Piechal, Alicja Jakimiuk, and Dagmara Mirowska-Guzel Excerpt from the article published in Pharmacological Reports 73, 1582–1594 (2021). Published: 05 August 2021. DOI: https://doi.org/10.1007/s43440-021-00310-7 Editor’s Highlights Sigma receptors are an insufficiently understood group of receptors. S1R is unlike any traditional receptor. Intracellularly, it acts as chaperones, facilitating the correct folding of other proteins, regulating inositol-3-phosphate […]
Continue ReadingAn Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies
By Parthena Martin, Thadd Reeder, Jo Sourbron, Peter A. M. de Witte, Arnold R. Gammaitoni, and Bradley S. Galer Excerpt from the article published in International Journal of Molecular Sciences 22, no. 16: 8416, 5 August 2021 DOI: https://doi.org/10.3390/ijms22168416 Editor’s Highlights Developmental and epileptic encephalopathies (DEEs) are debilitating conditions characterized by recurrent pharmacoresistant seizures of multiple […]
Continue ReadingExome Sequencing in 200 Intellectual Disability/Autistic Patients: New Candidates and Atypical Presentations
By Floriana Valentino, Lucia Pia Bruno, Gabriella Doddato, Annarita Giliberti, Rossella Tita, Sara Resciniti, Chiara Fallerini, Mirella Bruttini, Caterina Lo Rizzo, Maria Antonietta Mencarelli, Francesca Mari, Anna Maria Pinto, Francesca Fava, Margherita Baldassarri, Alessandra Fabbiani, Vittoria Lamacchia, Elisa Benetti, Kristina Zguro, Simone Furini, Alessandra Renieri, and Francesca Ariani Excerpt from the article published in Brain […]
Continue ReadingSigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
By Vladimir Zhemkov, Jen Liou, and Ilya Bezprozvanny Excerpt from the article published in Contact. January 2021. doi:10.1177/25152564211026505 Editor’s Highlights The endoplasmic reticulum (ER) is the largest cellular organelle and its function is to produce proteins for the rest of the cell to function. The ER membrane is organized into sub-compartments where specific signaling and […]
Continue ReadingFragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes
By B. Di Marco, P. Dell’Albani, S. D’Antoni, M. Spatuzza, C.M. Bonaccorso, S.A. Musumeci, F. Drago, B. Bardoni, and M.V. Catania Excerpt from the article published in Neurobiology of Disease, Volume 154, 2021, Doi: https://doi.org/10.1016/j.nbd.2021.105338. Editor’s Highlights Fragile X syndrome (FXS) is a common form of intellectual disability and autism caused by the lack of Fragile X Mental Retardation […]
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