Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases
By Yun Li, Hong Yang, Tianhan He, Liang Zhang, and Chao Liu Excerpt from the article published in Frontiers in Pharmacology, volume 12, 17 January 2022 , DOI: https://doi.org/10.3389/fphar.2021.775087 Editor’s Highlights Cav1.2, encoded by the CACNA1C gene, is a high-voltage-activated (HVA), long-lasting (L-type), and dihydropyridine (DHP)-sensitive calcium channel. Cav1.2 plays important roles in the cardiovascular system, the […]
Continue ReadingZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop
By Hammad Ghafoor, Han Chu, Jie Huang, Mengling Chen, Sha Wang, Jing Wang, and Jie Chao Excerpt from the article published in Toxicology and Applied Pharmacology, Volume 435, 2022, 115856, ISSN 0041-008X, https://doi.org/10.1016/j.taap.2021.115856 Editor’s Highlights ZC3H4 directly interacts with the Sigmar1 protein in the pulmonary fibroblast activation. Silicosis is a type of pulmonary fibrosis caused by […]
Continue ReadingAnalysis of LINE1 Retrotransposons in Huntington’s Disease
By Lavinia Floreani, Federico Ansaloni, Damiano Mangoni, Elena Agostoni, Remo Sanges, Francesca Persichetti and Stefano Gustincich Excerpt from the article published in Frontiers in Cellular Neuroscience, 14 January 2022 | https://doi.org/10.3389/fncel.2021.743797 Editor’s Highlights Abstract Transposable elements (TEs) are mobile genetic elements that made up about half the human genome. Among them, the autonomous non-LTR retrotransposon long […]
Continue ReadingAging is associated with increased brain iron through cortex-derived hepcidin expression
By Tatsuya Sato, Jason Solomon Shapiro, Hsiang-Chun Chang, Richard A Miller, and Hossein Ardehali Excerpt from the article published in eLife 11:e73456. DOI: https://doi.org/10.7554/eLife.73456 Editor’s Highlights Iron is critical for normal cell function, but its excess can lead to cellular damage due to oxidative stress. Iron accumulates in the brain cortex with aging and that this […]
Continue ReadingLewy body disease or diseases with Lewy bodies?
By Kateřina Menšíková, Radoslav Matěj, Carlo Colosimo, Raymond Rosales, Lucie Tučková, Jiří Ehrmann, Dominik Hraboš, Kristýna Kolaříková, Radek Vodička, Radek Vrtěl, Martin Procházka, Martin Nevrlý, Michaela Kaiserová, Sandra Kurčová, Pavel Otruba, and Petr Kaňovský Excerpt from the article published in npj Parkinson’s Disease volume 8, Article number: 3 (2022). Published: 10 January 2022 DOI: https://doi.org/10.1038/s41531-021-00273-9 […]
Continue ReadingExamination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use
By Lisa L. Wilson, Shainnel O. Eans, Insitar Ramadan-Siraj, Maria N. Modica, Giuseppe Romeo, Sebastiano Intagliata,and Jay P. McLaughlin Excerpt from the article published in International Journal of Molecular Sciences 23, no. 2: 615. Published: 6 January 2022, DOI: https://doi.org/10.3390/ijms23020615 Editor’s Highlights Chronic neuropathic pain is a common cause of decreased quality of life and disability […]
Continue ReadingSigma–1 receptor activation alleviates blood–brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF–GFRα1–RET pathway
By Danyang Liu, Luxi Yang, Peng Liu, Xuefei Ji, Xiaoxiao Qi, Ziqi Wang, Tianyan Chi, and Libo Zou Excerpt from the article published in Experimental Neurology, Volume 347, 2022, DOI: https://doi.org/10.1016/j.expneurol.2021.113867. Editors’ Highlights Sigma-1 receptor agonists could play an effective therapeutic role in preventing BBB damage in ischemic stroke and other cardiovascular conditions. Autors’ Highlights Sigma […]
Continue ReadingTherapeutics in the Pipeline Targeting α-Synuclein for Parkinson’s Disease
By Hilary Grosso Jasutkar, Stephanie E. Oh, and M. Maral Mouradian Excerpt from the article published in Pharmacological Reviews January 1, 2022, 74 (1) 207-237; DOI: https://doi.org/10.1124/pharmrev.120.000133 Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder and the fastest growing neurologic disease in the world, yet no disease-modifying therapy is available for this disabling condition. Multiple lines of […]
Continue ReadingORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
By John J Bassett , Mélanie Robitaille, Amelia A Peters, Alice H L Bong , Meng-Wong Taing, Ian A Wood, Francisco Sadras, Sarah J Roberts-Thomson, and Gregory R Monteith Introduction to the article published in FASEB J. 2022 Jan;36(1):e22108. DOI: 10.1096/fj.202002031RR PMID: 34939697. Editor’s Highlights The chaperone protein SigmaRl, the small conductance Ca2+-activated IC+ channels SK2 […]
Continue ReadingThe molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes
by Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Naznin Sultana Remex, Mahboob Morshed, Sadia Nitu, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, James Traylor, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan Excerpt from the article published in Mitochondrion, Volume 62, 2022, Pages 159-175, ISSN 1567-7249, https://doi.org/10.1016/j.mito.2021.12.002. Editor’s Highlights […]
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