Novel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands
By Ferenc Bogár, Lívia Fül. and Botond Penke Excerpt from the article published in Biomolecules 2022, 12, 363, Published: 25 February 2022, DOI: https://doi.org/10.3390/biom12030363 Editor’s Highlights Sigma-1 Receptor is a Central Regulator of Cell Survival As Sig-1R controls ER stress and the inflammatory processes in the cells, Sig-1R agonists have been tested in preclinical studies and […]
Continue ReadingImpact of Two Neuronal Sigma‐1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1‐42‐Injected, Wild‐Type Mouse Model of AD
By Emőke Borbély, Viktória Varga, Titanilla Szögi, Ildikó Schuster, Zsolt Bozsó, Botond Penke and Lívia Fülöp Excerpt from the article published in Int. J. Mol. Sci. 2022, 23, 2514. https://doi.org/10.3390/ijms23052514 Editor’s Highlights Adult neurogenesis is essential for CNS plasticity. In early AD, neurogenic impairment can be observed, accompanied by hyperreactive astrogliosis. The highly selective S1R […]
Continue ReadingImpact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD
By Emőke Borbély, Viktória Varga, Titanilla Szögi, Ildikó Schuster, Zsolt Bozsó, Botond Penke, and Lívia Fülöp Excerpt of the article published in International Journal of Molecular Sciences 23, no. 5: 2514., 24 February 2022, DOI: https://doi.org/10.3390/ijms23052514 Editor’s Highlights In early Alzheimer’s disease (AD), neurogenic impairment can be observed, accompanied by hyperreactive astrogliosis. Neuronal sigma-1 receptors (S1Rs) […]
Continue ReadingMonitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
By Laura Torres-Garcia, Joana M. P. Domingues, Edoardo Brandi, Caroline Haikal, Janitha M. Mudannayake, Inês C. Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F. Outeiro, Gunnar K. Gouras, and Jia-Yi Li Excerpt from the article published in Scientific Reports volume 12, Article number: 2987 Published: 22 February 2022 DOI: https://doi.org/10.1038/s41598-022-06846-9 Editor’s Highlights α-synuclein (aSyn) is […]
Continue ReadingPharmacologic Management of Persistent Pain in Cancer Survivors
by Glare, P., Aubrey, K., Gulati, A. et al. Excerpt from the article published in Drugs (2022). https://doi.org/10.1007/s40265-022-01675-6 Editor’s Highlights Abstract Improvements in screening, diagnosis and treatment of cancer has seen cancer mortality substantially diminish in the past three decades. It is estimated there are almost 20 million cancer survivors in the USA alone, but some 40% […]
Continue ReadingSigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome
by Song, L., Bekdash, R., Morikawa, K. et al. Excerpt from the article published in Nat Cardiovasc Res 1, 142–156 (2022). https://doi.org/10.1038/s44161-021-00016-2 Editor’s Highlights Mutations in the CACNA1C gene, encoding the α2δ-1 subunit in the calcium channel CaV1.2, cause a life-threatening form of long QT syndrome (LQTS) named Timothy syndrome. SIGMA-1 receptor could be a therapeutic target for TS and […]
Continue ReadingPERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
By Ping Fan and V. Craig Jordan Excerpt from the article published in Molecular Cancer Research, 1 February 2022; 20 (2): 193–201. https://doi.org/10.1158/1541-7786.MCR-21-0702 Editor’s Highlights Sigma-1 receptor (Sig1R), an endoplasmic reticulum-resident membrane protein, stabilizes IP3R and highly interacts with the chaperone protein GRP78 to regulate Ca2+ exchange at MAMs. Overexpression of Sig1R suppresses PRK-like endoplasmic reticulum kinase (PERK) […]
Continue ReadingMitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes
By Ana Catarina Pereira, Nuno Madeira, Sofia Morais, António Macedo, Maria Teresa Cruz, and Cláudia M. F. Pereira Excerpt from the article published in Cells 11, no. 3: 433, 27 January 2022, DOI: https://doi.org/10.3390/cells11030433 Editor’s Highlights Activation of the the Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been implicated in a wide range of […]
Continue ReadingSigma-1 receptor increases intracellular calcium in cultured astrocytes and contributes to mechanical allodynia in a model of neuropathic pain
By Jae-Gyun Choi, Sheu-Ran Choi, Dong-Wook Kang, Jaehyuk Kima, Jin Bong Park, Jang-Hern Lee, and Hyun-Woo Kim Introduction to the article published in Brain Research Bulletin, Volume 178, January 2022, Pages 69-81 DOI: https://doi.org/10.1016/j.brainresbull.2021.11.010 Autors’ Highlights Abstract Recent studies have revealed that glial sigma-1 receptor (Sig-1R) in the spinal cord may be a critical factor […]
Continue ReadingSigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone
By Rebecca S. Hornung, Namrata GR Raut, Daisy J. Cantu, Lauren M Lockhart, and Dayna L. Averitt Excerpt from the article published in Molecular Pain. January 2022. DOI: 10.1177/17448069211069255 Editor’s Highlights Pain signaled by the trigeminal nociceptors is common, often debilitating, and includes musculoskeletal, neurovascular, and neuropathic pain Trigeminal sensory neurons are an anatomical substrate for the […]
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