Maladaptive myelination promotes generalized epilepsy progression
By Juliet K. Knowles, Haojun Xu, Caroline Soane, Ankita Batra, Tristan Saucedo, Eleanor Frost, Lydia T. Tam, Danielle Fraga, Lijun Ni, Katlin Villar, Sydney Talmi, John R. Huguenard, and Michelle Monje Excerpt from the article published in Nature Neuroscience 25, 596–606 (2022). https://doi.org/10.1038/s41593-022-01052-2 Editor’s Highlights Absence seizures occur in multiple forms of human generalized epilepsy and are […]
Continue ReadingThe ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors
By Elizabeth G. Hunt, Alex M. Andrews, Sydney R. Larsen, and Jessica E. Thaxton Excerpt from the article published in Frontiers in Cell and Developmental Biology, volume 10, 27 April 2022 | https://doi.org/10.3389/fcell.2022.867341 Editor’s Highlights T cells are an immune subset exhibiting robust dependence on ER and mitochondrial function based on the need for protein synthesis and […]
Continue ReadingChronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension
By Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang & Bo Yang (2022) Excerpt from the article published in Bioengineered, 13:4, 10843-10856, DOI: 10.1080/21655979.2022.2065953 Editor’s Highlights Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive elevation in mean pulmonary artery pressure, which […]
Continue ReadingEffects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats
By Sándor Váczi, Lilla Barna, Krisztián Laczi, Ferenc Tömösi, Gábor Rákhely, Botond Penke, Lívia Fülöp, Ferenc Bogár, Tamás Janáky, Mária A. Deli, and Zsófia Mezei Excerpt from the article published in European Journal of Pharmacology, 2022, 174983 Doi: https://doi.org/10.1016/j.ejphar.2022.174983. Editor’s Highlights Only a fraction of all cardiovascular diseases is of cardiac origin, and macro-and microvascular […]
Continue ReadingActivation of Sigma-1 Receptor Alleviates ER-Associated Cell Death and Microglia Activation in Traumatically Injured Mice
By Mingming Shi, Liang Liu, Xiaobin Min, Liang Mi, Yan Chai, Fanglian Chen, Jianhao Wang, Shuyuan Yue, Jianning Zhang, Quanjun Deng, and Xin Chen Excerpt from the article published in Journal of Clinical Medicine 2022, 11, 2348 Doi: https://doi.org/10.3390/jcm11092348 Editor’s Highlights The sigma-1 receptor (Sig-1R) is a ubiquitous ER-resident chaperone localized acting as a dynamic pluripotent […]
Continue ReadingDivergent Ca2+/calmodulin feedback regulation of CaV1 and CaV2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and Bilateria
By Julia Gauberg, Wassim Elkhatib, Carolyn L. Smith, Anhadvir Singh, and Adriano Senatore Excerpt from the article published in Journal of Biological Chemistry, volume 298, 4, 101741, April 2022, DOI: https://doi.org/10.1016/j.jbc.2022.101741 Editor’s Highlights Voltage-gated calcium (CaV) channels belong to a vast eukaryotic lineage of four-domain channels, which in animals includes voltage-gated sodium (NaV) and NALCN sodium leak channels. […]
Continue ReadingAmyloid Cascade Hypothesis for the Treatment of Alzheimer’s Disease: Progress and Challenges
By Tong Wu , Ding Lin , Yaqian Cheng , Senze Jiang , Muhammad Waheed Riaz , Nina Fu , Chenhao Mou , Menglu Ye , and Ying Zheng. Excerpt from the article published in Aging and disease. 2022. Doi: 10.14336/AD.2022.0412 Editor’s Highlights Nowadays, the significance and complexity of the amyloid cascade hypothesis in the development of Alzheimer’s disease have been undisputed. The origin of the Aβ pathogenic pathway is mostly considered […]
Continue ReadingSigma 2 receptor (σ2R/TMEM97) in Retinal Ganglion Cell Degeneration
By Hua Wang, Zhiyou Peng, Yiwen Li et al. Excerpt from the article published in Retinal Ganglion Cell Degeneration, 15 March 2022, PREPRINT (Version 1) available at Research Square Doi: https://doi.org/10.21203/rs.3.rs-1439890/v1 Editor’s Highlights The sigma 2 receptor (σ2R) plays a signicant role in the retinal ganglion cell (RGC) degeneration pathway and that inhibiting σ2R/TMEM97 function is […]
Continue ReadingNew insights into the genetic etiology of Alzheimer’s disease and related dementias
By Bellenguez, C., Küçükali, F., Jansen, I.E. et al. Excerpt from the article published in New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet (2022). https://doi.org/10.1038/s41588-022-01024-z Editor’s Highlights The pathway enrichment analyses removed ambiguities concerning the involvement of tau-binding proteins and APP/Aβ peptide metabolism in late-onset AD processes at a much higher level than […]
Continue ReadingCalcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1
By Yousra El Ghaleb, Nadine J. Ortner, Wilfried Posch, Monica L. Fernández-Quintero, Wietske E. Tuinte, Stefania Monteleone, Henning J. Draheim, Klaus R. Liedl, Doris Wilflingseder, Jörg Striessnig, Petronel Tuluc, Bernhard E. Flucher, and Marta Campiglio Excerpt from the article published by Journal of General Physiology, 5 September 2022; 154 (9): e202213182. DOI: https://doi.org/10.1085/jgp.202113028 Editor’s Highlights CaV1.1 […]
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