Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review
By Peng Chen, Fuchao Chen, and Benhong Zhou Excerpt from the article published in Journal of Integrative Neuroscience (JIN) 2022, 21(4), 102. Published: 30 May 2022. DOI: https://doi.org/10.31083/j.jin2104102 Editor’s Highlights Epilepsy is a prevalent, chronic, and severe neurological disorder characterized by abnormal hypersynchrony of a large population of neurons. It is widely assumed that there is an […]
Continue ReadingSigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism
By Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Rene Rost, Roland Malli, and Wolfgang F. Graier Excerpt from the article published in Biomolecules. 2022; 12(6):762. DOI https://doi.org/10.3390/biom12060762 Editor’s Highlights Sigma-1 Receptor (S1R) is an integral membrane protein, a unique ligand-activated chaperone, localized to the endoplasmic reticulum (ER) and highly enriched in specialized regions named mitochondria-associated […]
Continue ReadingMolecular function of Sigma-1 receptor in obesity-induced metabolic dysfunction
By Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Jonette M. Green, A. Wayne Orr, Matthew D. Woolard, Aimee E. Vozelinek, Norman R. Harris, Randa S. Eshaq, Christopher G. Kevil, and Shenuarin Bhuiyan Introduction to the article published in Journal of Molecular and Cellular Cardiology, 046| VOLUME 112, P149, NOVEMBER 01, 2017, DOI: https://doi.org/10.1016/j.yjmcc.2017.07.058 Editor’s Highlights Sigma-1 receptor (Sigmar1) […]
Continue ReadingFluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
By Aurelio J. Dregni, Pu Duan, Hong Xu, Lakshmi Changolkar, Nadia El Mammeri, Virginia M.-Y. Lee, and Mei Hong Excerpt from the article published in Nature Communications 13, 2967 (2022). https://doi.org/10.1038/s41467-022-30585-0 Editor’s Highlights Alzheimer’s disease (AD) is defined by intracellular neurofibrillary tangles formed by the microtubule-associated protein tau and extracellular plaques formed by the β-amyloid peptide. Extensive […]
Continue ReadingTargeting ER-Mitochondria Signaling as a Therapeutic Target for Frontotemporal Dementia and Related Amyotrophic Lateral Sclerosis
By Sandra M. Martín-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Shaakir Salam, Wendy Noble and Christopher C. J. Miller Excerpt from the article published in Frontiers in Cell and Developmental Biology, volume 10, 27 May 2022 DOI: https://doi.org/10.3389/fcell.2022.915931 Editor’s Highlights Endoplasmic reticulum (ER) and mitochondria signaling is damaged in Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) […]
Continue ReadingCell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases
By Yiran E. Li, James R. Sowers, Claudio Hetz, and Jun Ren Excerpt from the article published in Cell Death Dis 13, 504 (2022). https://doi.org/10.1038/s41419-022-04942-2 Editor’s Highlights Mutually coupled membrane components between mitochondria and ER, referred to as mitochondria-associated membranes (MAMs). MAMs refer to the complex of outer mitochondrial membrane (OMM) and ER segregated by a distance […]
Continue ReadingIntracellular Aβ42 Aggregation Leads to Cellular Thermogenesis
By Chyi Wei Chung, Amberley D. Stephens, Tasuku Konno, Edward Ward, Edward Avezov, Clemens F. Kaminski, Ali A. Hassanali, and Gabriele S. Kaminski Schierle Excerpt from the article published in Journal of the American Chemical Society, Publication Date: May 26, 2022, DOI: https://doi.org/10.1021/jacs.2c03599 Editor’s Highlights Abstract The aggregation of Aβ42 is a hallmark of Alzheimer’s […]
Continue ReadingNeuroprotective Effects of σ2R/TMEM97 Receptor Modulators in Neuronal Model of Huntington’s Disease
By Jing Jin, Nicolas Arbez, James J. Sahn, Yan Lu, Kathryn T. Linkens, Timothy R. Hodges, Anthony Tang, Robyn Wiseman, Stephen F. Martin, and Christopher A. Ross Excerpt from the preprint published by ChemRxiv. Cambridge: Cambridge Open Engage; 2022; DOI 10.26434/chemrxiv-2022-l6xtv This content has not been peer-reviewed. Editor’s Highlights Huntington’s disease (HD) is a genetic […]
Continue ReadingSigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2
By Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, and Fengdong Zhao Excerpt from the article published in EMBO Molecular Medicine e15373 25 May 2022 DOI: https://doi.org/10.15252/emmm.202115373 Editor’s Highlights Abstract Sigma-1 receptor (Sigmar1) is a […]
Continue ReadingSARS-CoV-2 NSP3, NSP4 and NSP6 mutations and Epistasis during the pandemic in the world: Evolutionary Trends and Natural Selections in Six Continents
By Haniyeh fooladinezhad, Maryamsadat Shahidi, Mohammadamin Mahmanzar, Bahar Mahdavi, Samaneh Tokhanbigli, Mahsa Mollapour Sisakht, Bahman Moradi, Mohamad Reza Ganjalikhany, Karim Rahimian, and Mazdak Ganjndalikhani-Hakemi Excerpt from the article published in medRxiv 2022.05.22.22275422; DOI: https://doi.org/10.1101/2022.05.22.22275422 Editor’s Highlights The key stage of the SARS-CoV-2 life cycle is virus replication in infected cells. During this process, several viral proteins facilitate […]
Continue Reading