Mitochondrial dysfunction in cell senescence and aging
By Satomi Miwa, Sonu Kashyap, Eduardo Chini, and Thomas von Zglinicki Excerpt from the article in Journal of Clinical Investigation 2022;132(13):e158447. Published July 1, 2022, DOI: https://doi.org/10.1172/JCI158447. Editor’s Highlights Mitochondrial dysfunction in aging tissues and senescent cells is a decrease in respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential (MMP) at steady […]
Continue ReadingAstrocytes: the neglected stars in the central nervous system and drug addiction
By Wenjun Chen, Shiqiu Meng, Ying Han, and Jie Shi Excerpt from the article published in Medical Review, vol. , no. , 2022. Published online: June 29, 2022 DOI: https://doi.org/10.1515/mr-2022-0006 Editor’s Highlights The star-shaped astrocyte, one dominant type of glia, has been implicated in myriad biological processes of the central nervous system (CNS) by interacting […]
Continue ReadingNMDA and AMPA Receptors at Synapses: Novel Targets for Tau and α-Synuclein Proteinopathies
By Maria Italia, Elena Ferrari, Monica Diluca, and Fabrizio Gardoni Excerpt from the article published in Biomedicines 10, no. 7: 1550. Published: 29 June 2022 DOI: https://doi.org/10.3390/biomedicines10071550 Editor’s Highlights Aberrant levels, post-translational modifications (PTMs), mislocalization, and aggregation of tau and α-synuclein have been widely described in Alzheimer’s disease (AD) and related tauopathies and Parkinson’s disease (PD) […]
Continue Reading(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration
By Manjuan Peng, Xuezhi Zhou, Fei Yao, Haibo Li, Weitao Song, Siqi Xiong, and Xiaobo Xia Excerpt from the article published in Frontiers in Medicine, volume 9, 27 June 2022, DOI: https://doi.org/10.3389/fmed.2022.879901 Editor’s Highlights Dry age-related macular degeneration (AMD) accounts for approximately 5.8% of legal blindness globally and is the leading cause of severe vision […]
Continue ReadingThe Impact of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis
By Jiantao Zhao, Xuemei Wang, Zijun Huo, Yanchun Chen, Jinmeng Liu, Zhenhan Zhao, Fandi Meng, Qi Su, Weiwei Bao, Lingyun Zhang, Shuang Wen, Xin Wang, Huancai Liu, and Shuanhu Zhou Excerpt from the article published in Cells 11, no. 13: 2049. Published: 28 June 2022. DOI: https://doi.org/10.3390/cells11132049 Editor’s Highlights Amyotrophic lateral sclerosis (ALS) is a rapidly […]
Continue ReadingDefining the Ligand-dependent Interactome of the Sigma 1 Receptor
By Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, and Kathryn E. Bollinger Excerpt from the article published in bioRxiv 2022.06.22.497210; Published June 25, 2022, DOI: https://doi.org/10.1101/2022.06.22.497210 Editor’s Highlights The sigma 1 receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions. S1R has […]
Continue ReadingKSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential
By Kamil Mika, Małgorzata Szafarz, Monika Zadrożna, Barbara Nowak, Marek Bednarski, Katarzyna Szczepańska, Krzysztof Pociecha, Monika Kubacka, Noemi Nicosia, Izabela Juda, Katarzyna Kieć-Kononowicz, and Magdalena Kotańska Excerpt from the article published in International Journal of Molecular Sciences 2022 23, no. 13: 7011. Published: 24 June 2022. DOI: https://doi.org/10.3390/ijms23137011 Editor’s Highlights Ligands for H3/sigma-2 receptors promote the […]
Continue ReadingHaloperidol Instigates Endometrial Carcinogenesis and Cancer Progression by the NF-κB/CSF-1 Signaling Cascade
By Jung-Ying Chiang, Fu-Ju Lei, Huan-Jui Chang, Sung-Tai Wei, Chi-Chung Wang, Yen-Chih Huang, Hwai-Lee Wang, Chi-Fen Chuang, Shu-Yu Hu and Chia-Hung Hsieh Excerpt from the article published in Cancers 2022, 14(13), 3089; Published: 23 June 2022, DOI https://doi.org/10.3390/cancers14133089 Editor’s Highlights Haloperidol restrains cell proliferation and initiates apoptosis in human melanoma, colon cancer, and breast cancer cells by binding […]
Continue ReadingProgesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer’s Disease
By Xin Xu, Xiangyan Ruan, Rui Ju, Zhikun Wang, Yu Yang, Jiaojiao Cheng, Muqing Gu, and Alfred O. Mueck Excerpt from the article published in American Journal of Alzheimer’s Disease & Other Dementias. 2022. Published June 22, 2022 DOI:10.1177/15333175221109749 Editor’s Highlights Cerebral amyloid angiopathy (CAA) is found in the majority of Alzheimer’s disease (AD) cases. The […]
Continue ReadingNeuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?
By Helena Targa Dias Anastacio, Natalie Matosin, and Lezanne Ooi Excerpt from the article published in Translational Psychiatry 2022, volume 12, Article number: 257 Published: 22 June 2022, DOI: https://doi.org/10.1038/s41398-022-02024-7 Editor’s Highlights Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to loss of cognitive abilities and ultimately, death. With no cure available, limited […]
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