Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function
By Zhanwei Zeng, Shiyi Liao, Huan Zhou, Hongyu Liu, Jiantao Lin, Yunsheng Huang, Chenhui Zhou, and Daohua Xu Excerpt from the article published in Frontiers in Pharmacology, 31 August 2022, Sec. Pharmacology of Anti-Cancer Drugs, DOI: https://doi.org/10.3389/fphar.2022.952980 Editor’s Highlights Female breast cancer is one of the most common malignancies in the world, with an estimated 2.3 […]
Continue ReadingAntipsychotics function as epigenetic age regulators in human neuroblastoma cells
By Jianbin Du, Yutaka Nakachi, Ayaka Fujii, Shinya Fujii, Miki Bundo, and Kazuya Iwamoto Excerpt from the article published in Schizophrenia 8, 69, 29 August 2022. DOI: https://doi.org/10.1038/s41537-022-00277-1 Editor’s Highlights Schizophrenia is proposed to be a syndrome of accelerated aging in the body, which is partly the cause of the shortened lifespan of patients with schizophrenia. […]
Continue ReadingAdenosine A2A receptors control synaptic remodeling in the adult brain
By Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, and Joana M. Marques Excerpt from the article published in Scientific Reports 12, 14690, 29 August 2022, DOI: https://doi.org/10.1038/s41598-022-18884-4 Editor’s […]
Continue ReadingThe Potential of Small Molecules to Modulate the Mitochondria–Endoplasmic Reticulum Interplay in Alzheimer’s Disease
By Giacomo Dentoni, Laura Castro-Aldrete, Luana Naia, and Maria Ankarcrona Excerpt from the article published in Frontiers in Cell and Developmental Biology, 26 August 2022Sec. Signaling, DOI: https://doi.org/10.3389/fcell.2022.920228 Editor’s Highlights Alzheimer’s disease (AD) research is shifting toward considering the disorder as a multifactorial disease, characterized by different types of microdamage and different factors that lead […]
Continue ReadingInteractome overlap between risk genes of epilepsy and targets of anti-epileptic drugs
By Yu-Qin Lv, Xing Wang, Yu-Zhuang Jiao, Yan-Hua Wang, Na Wang, Lei Gao, and Jing-Jun Zhang Excerpt from the article published in Plos One, August 25, 2022, DOI: https://doi.org/10.1371/journal.pone.0272428 Editor’s Highlights Epilepsy is a widespread chronic nervous system disease, which affects about 70 million people all over the world. With the development of sequencing technology, […]
Continue ReadingMitochondria-Associated Endoplasmic Reticulum Membranes: Inextricably Linked with Autophagy Process
By Chonghao Ji, Zhanwei Zhang, Zechuan Li, Xiao She, Xiaoya Wang, Binyang Li, Xin Xu, Dawei Song, and Dongjiao Zhang Excerpt from the article published in Oxidative Medicine and Cellular Longevity (Hindawi), Volume 2022, 23 Aug 2022, Article ID 7086807, DOI: https://doi.org/10.1155/2022/7086807 Editor’s Highlights There is a growing body of evidence indicating Mitochondria-associated membranes (MAMs) act as […]
Continue ReadingLysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
By Ying Xue Xie, Nima N. Naseri, Jasmine Fels, Parinati Kharel, Yoonmi Na, Diane Lane, Jacqueline Burré, and Manu Sharma Excerpt from the article published in Nature Communications 13, 4918, 22 August 2022, DOI: https://doi.org/10.1038/s41467-022-32625-1 Editor’s Highlights The release of pathogenic aggregates of the neuronal protein α-Synuclein (αSyn) into the extracellular space instigate the neuron-to-neuron transmission […]
Continue ReadingEarlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
By Lukas Frontzkowski, Michael Ewers, Matthias Brendel, Davina Biel, Rik Ossenkoppele, Paul Hager, Anna Steward, Anna Dewenter, Sebastian Römer, Anna Rubinski, Katharina Buerger, Daniel Janowitz, Alexa Pichet Binette, Ruben Smith, Olof Strandberg, Niklas Mattsson Carlgren, Martin Dichgans, Oskar Hansson, and Nicolai Franzmeier Excerpt from the article published in Nature Communications 13, 4899, 20 August 2022, DOI: […]
Continue ReadingGPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1
By Dandan Ma, Wei Sun, Cuicui Fu, Kamran Nazmi, Enno C. I. Veerman, Richard T. Jaspers, Jan G. M. Bolscher, Floris J. Bikker, and Gang Wu Excerpt from the article published in International Journal of Oral Science volume 14, Article number: 42 (2022), 15 August 2022, DOI: https://doi.org/10.1038/s41368-022-00181-5 Editor’s Highlights The histatin (Hst) peptide family […]
Continue ReadingRoles of Transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle
By Masafumi Tenta, Jun Eguchi, and Jun Wada Excerpt from the article published in Acta Medica Okayama, 2022 Jun; 76 (3):235-245. DOI: 10.18926/AMO/63717 Editor’s Highlights Sarcopenic obesity, the combination of sarcopenia and obesity, is defined as reduced skeletal muscle mass and muscle strength in parallel with increased adiposity. Adipose tissue is the major site for the […]
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