Safe and Efficient Sigma1 Ligand: A Potential Drug Candidate for Multiple Sclerosis
By Bénédicte Oxombre, Fahima Madouri, Anne-Sophie Journé, Séverine Ravez, Eloise Woitrain, Pascal Odou, Nathalie Duhal, Sandro Ninni, David Montaigne, Nadira Delhem, Patrick Vermersch, and Patricia Melnyk Excerpt from the article published in International Journal of Molecular Sciences 23, no. 19: 11893. 6 October 2022. DOI: https://doi.org/10.3390/ijms231911893 Editor’s Highlights In the last few decades, the sigma1 (S1R) […]
Continue ReadingRepeated inhibition of sigma-1 receptor suppresses GABAA receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors
By Yaoyao Qin, Weixing Xu, Kunpeng Li, Qi Luo, Xi Chen, Yue Wang, Lei Chen, and Sha Sha Excerpt from the article published in Frontiers in Molecular Neuroscience, 30 September 2022Sec. Brain Disease Mechanisms, DOI: https://doi.org/10.3389/fnmol.2022.959224 Editor’s Highlights Abstract Sigma-1 receptor (σ1R) downregulation in male mice is known to cause a depressive-like phenotype. The nucleus […]
Continue ReadingBispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids
By Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, and José Miguel Vela Excerpt from the article published in Acta Pharmaceutica Sinica B, September 25, 2022, ISSN 2211-3835, DOI: https://doi.org/10.1016/j.apsb.2022.09.018 […]
Continue ReadingSmall soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
By Derya Emin, Yu P. Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I. Sideris, Jeff Y. L. Lam, Rohan T. Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P. J. Knowles, Michele Vendruscolo, Francesco S. Ruggeri, Franklin I. Aigbirhio, Caroline H. Williams-Gray, and David Klenerman Excerpt from the article published […]
Continue ReadingAge-dependent neurodegeneration and neuroinflammation in a genetic A30P/A53T double-mutated α-synuclein mouse model of Parkinson’s disease
By Lisa Rauschenberger, Jennifer Behnke, Alexander Grotemeyer, Susanne Knorr, Jens Volkmann, and Chi Wang Excerpt from the article published in Neurobiology of Disease, Volume 171, September 2022, 105798, ISSN 0969-9961, DOI: https://doi.org/10.1016/j.nbd.2022.105798. Editor’s Highlights Authors’ Highlights Abstract The pathogenesis of Parkinson’s disease (PD) is closely interwoven with the process of aging. Moreover, increasing evidence from human postmortem […]
Continue ReadingDifferential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism
By Jing Li, Elisa Félix-Soriano, Katherine R. Wright, Hongtao Shen, Lisa A. Baer, Kristin I. Stanford, and Lian-Wang Guo Excerpt from the article published in International Journal of Molecular Sciences 23, no. 18: 10846. 16 September 2022, DOI: https://doi.org/10.3390/ijms231810846 Editor’s Highlights Obesity predisposes patients to comorbidities, including type 2 diabetes and cardiovascular disease, that significantly increase […]
Continue ReadingSpecific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo
By Qing Liu, Qilin Guo, Li-Pao Fang, Honghong Yao, Anja Scheller, Frank Kirchhoff, and Wenhui Huang Excerpt from the article published in Journal of Neurochemistry, 00, 1– 22, 09 September 2022, DOI: https://doi.org/10.1111/jnc.15693 Editor’s Highlights Abstract The chaperon protein sigma-1 receptor (S1R) has been discovered over 40 years ago. Recent pharmacological studies using S1R exogenous ligands demonstrated a promising […]
Continue ReadingClinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer’s disease
By Ibtisam Mumtaz, Mir Owais Ayaz, Mohamad Sultan Khan, Umar Manzoor, Mohd Azhardin Ganayee, Aadil Qadir Bhat, Ghulam Hassan Dar, Badrah S. Alghamdi, Anwar M. Hashem, Mohd Jamal Dar, Gulam Md. Ashraf, and Tariq Maqbool Excerpt from the article published in Frontiers in Aging Neuroscience, 07 September 2022, Sec. Alzheimer’s Disease and Related Dementias, DOI: […]
Continue ReadingThe Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membranes
By Jacek Krzysko, Filip Maciag, Anna Mertens, Baran Enes Güler, Joshua Linnert, Karsten Boldt, Marius Ueffing, Kerstin Nagel-Wolfrum, Martin Heine, and Uwe Wolfrum Excerpt from the article published in Cells. 2022; 11(18):2790. 7 September 2022. DOI: https://doi.org/10.3390/cells11182790 Editor’s Highlights The VLGR1 (very large G protein-coupled receptor-1), also known as ADGRV1, GPR98, and MASS, is the […]
Continue ReadingHigh Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations
By Andrea Sturchio , Alok K Dwivedi, Tarja Malm, Matthew J A Wood, Roberto Cilia, Jennifer S Sharma, Emily J Hill, Lon S Schneider, Neill R Graff-Radford, Hiroshi Mori, Georg Nübling, Samir El Andaloussi, Per Svenningsson, Kariem Ezzat, Alberto J Espay, and Dominantly Inherited Alzheimer Consortia (DIAN) Extract of the article published in Journal of […]
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