Role of transient receptor potential ankyrin 1 (TRPA1) on nociception caused by a murine model of breast carcinoma
By Amanda Spring de Almeida, Flávia Karine Rigo, Samira Dal-Toé De Prá, Alessandra Marcone Milioli, Gabriele Cheiran Pereira, Débora Denardin Lückemeyer, Caren Tatiane Antoniazzi, Sabrina Qader Kudsi, Daniel Mendes Pereira Ardisson Araújo, Sara Marchesan Oliveira, Juliano Ferreira, and Gabriela Trevisan Excerpt from the article published in Pharmacological Research, Volume 152, February 2020, 104576, ISSN 1043-6618, […]
Continue ReadingLigands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels
By Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos and Javier Garzón Excerpt from the article published in Frontiers in Pharmacology, 2019 volume 10 DOI=10.3389/fphar.2019.00634 Editor’s Highlights The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. TRP ankyrin member 1 (TRPA1) receptors are coexpressed with TRPV1 […]
Continue ReadingTRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain
By Miguel Ortíz-Rentería, Rebeca Juárez-Contreras, Ricardo González-Ramírez, and Sara L. Morales-Lázaro Excerpt from the article published in PNAS, January 29, 2018, 115 (7) E1657-E1666, DOI: https://doi.org/10.1073/pnas.1715972115 Significance The TRPV1 ion channel has been widely associated with the generation of painful responses. The responses of cells expressing this ion channel and, presumably, the overall pain response of an […]
Continue ReadingSigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice
By James J Sahn, Galo L Mejia, Pradipta R Ray, Stephen F Martin, and Theodore J Price Excerpt from the article published in ACS chemical neuroscience, 2017 Aug 16;8(8):1801-1811. DOI: https://doi.org/10.1021/acschemneuro.7b00200 Free PMC article Editor’s Highlights Abstract Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be […]
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