Accurate Prediction of Virus-Host Protein-Protein Interactions via a Siamese Neural Network Using Deep Protein Sequence Embeddings
By Sumit Madan, Victoria Demina, Marcus Stapf, Oliver Ernst, and Holger Froehlich Excerpt from the preprint article published in bioRxiv 2022.05.31.494170; DOI: https://doi.org/10.1101/2022.05.31.494170 Editor’s Highlights Prediction and understanding of tissue-specific virus-host interactions have relevance for the development of novel therapeutic intervention strategies. A novel deep learning approach to predict virus-host protein-protein interactions (PPIs), is the method (Siamese Tailored […]
Continue ReadingMitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
By Zonghan Liu, Yi Sun, Zhengtang Qi, Lu Cao, and Shuzhe Ding Excerpt from the article published in Cell and Bioscience 12, 66 (2022). Published: 19 May 2022, DOI: https://doi.org/10.1186/s13578-022-00805-7 Editor’s Highlights Mitochondria are semiautonomous, semiself-replicating, highly dynamic organelles, endowed with their own circular, double-stranded DNA molecule that spans 16.6 kb and intramitochondrial replication and translational machinery. Intercellular mitochondrial […]
Continue ReadingIntracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy
By Sergei Kopanchuk, Edijs Vavers , Santa Veiksina, Kadri Ligi, Liga Zvejniece, Maija Dambrova, and Ago Rinken Excerpt from the article published in PLoS ONE 17(5): e0268563. May 18, 2022, DOI: https://doi.org/10.1371/journal.pone.0268563 Editor’s Highlights The sigma-1 receptor (Sig1R) has been described as an intracellular protein modulator, a chaperone protein that localizes in the endoplasmic reticulum […]
Continue ReadingCellular interorganelle crosstalk in health and disease states: A glimpse on nephrology-related conditions
By Fateme Shamekhi Amiri Excerpt from the article published in Archives of Clinical Nephrology 8(1): 007-027. DOI: 10.17352/acn.000059 Editor’s Highlights Mitochondria as a signalling organelle associates with the cellular signalling environment and mediates gene expression programs. Mitochondria are constantly interacting with other organelles through signalling pathways, and on some occasions even though physical contact sites. Sigma-1receptor […]
Continue ReadingSigma 2 receptor (σ2R/TMEM97) in Retinal Ganglion Cell Degeneration
By Hua Wang, Zhiyou Peng, Yiwen Li et al. Excerpt from the article published in Retinal Ganglion Cell Degeneration, 15 March 2022, PREPRINT (Version 1) available at Research Square Doi: https://doi.org/10.21203/rs.3.rs-1439890/v1 Editor’s Highlights The sigma 2 receptor (σ2R) plays a signicant role in the retinal ganglion cell (RGC) degeneration pathway and that inhibiting σ2R/TMEM97 function is […]
Continue ReadingNovel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands
By Ferenc Bogár, Lívia Fül. and Botond Penke Excerpt from the article published in Biomolecules 2022, 12, 363, Published: 25 February 2022, DOI: https://doi.org/10.3390/biom12030363 Editor’s Highlights Sigma-1 Receptor is a Central Regulator of Cell Survival As Sig-1R controls ER stress and the inflammatory processes in the cells, Sig-1R agonists have been tested in preclinical studies and […]
Continue ReadingThe molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes
by Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Naznin Sultana Remex, Mahboob Morshed, Sadia Nitu, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, James Traylor, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan Excerpt from the article published in Mitochondrion, Volume 62, 2022, Pages 159-175, ISSN 1567-7249, https://doi.org/10.1016/j.mito.2021.12.002. Editor’s Highlights […]
Continue ReadingBRD2 regulation of sigma-2 receptor upon cholesterol deprivation
By Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, and Lian-Wang GuoLife Excerpt from the article published in Science Alliance Nov 2020, 4 (1) e201900540; DOI: 10.26508/lsa.201900540 Editor’s Highlights Sigma-2 receptor is a recently unveiled player in cholesterol homeostasis. Bromodomain BRD2 and SREBP2 (sterol regulatory element-binding protein 2) cooperatively regulates S2R transcription. […]
Continue ReadingHighly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells
By David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy, and Michael H. Norris Excerpt from the article published in Pathogens. 2021; 10(11):1514. https://doi.org/10.3390/pathogens10111514 Editor’s […]
Continue ReadingRevisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders
by Kinga Sałaciak, Karolina Pytka Excerpt from the article published in Neuroscience & Biobehavioral Reviews Volume 132, January 2022, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2021.10.037. Editor’s Highlights Sigma-1 receptors are unique therapeutic targets modulating the activity of various proteins and systems in the organism. Preclinical studies reported that sigma-1 receptor expression correlates with the clinical manifestation of disease. […]
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