Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
By Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire […]
Continue ReadingSigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics
By Reed L. Berkowitz, Andrew P. Bluhm, Glenn W. Knox, Christopher R. McCurdy, David A. Ostrov, and Michael H. Norris Excerpt from the article published in International Journal of Molecular Sciences. 29 October 2023; 24(21):15718. DOI: https://doi.org/10.3390/ijms242115718 Editor’s Highlights Abstract The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of […]
Continue ReadingSigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis
By Nhi T. Nguyen, Valeria Jaramillo-Martinez, Marilyn Mathew, Varshini V. Suresh, Sathish Sivaprakasam, Yangzom D. Bhutia, and Vadivel Ganapathy Excerpt from the article published in International Journal of Molecular Sciences. 28 September 2023; 24(19):14672. DOI: https://doi.org/10.3390/ijms241914672 Editor’s Higlights Abstract Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or heme and also several unrelated xenobiotics/chemicals. They […]
Continue ReadingThe Emerging Role of Sigma Receptors in Pain Medicine
By Joseph Pergolizzi Jr and Giustino Varrassi Excerpt from the article published in Cureus 15(7): e42626. July 28, 2023, doi:10.7759/cureus.42626 Abstract Sigma receptors are protein chaperones with the unexpected characteristic of being activated by ligand binding. As such, they represent intriguing new targets for potential drug development. As a protein chaperone, these “receptors” escort proteins from […]
Continue ReadingDefining the ligand-dependent proximatome of the sigma 1 receptor
By Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, and Kathryn E. Bollinger Excerpt from the article published in Frontiers in Cell and Developmental Biology, 11, 07 June 2023Sec. Membrane Traffic, DOI: 1045759.https://doi.org/10.3389/fcell.2023.1045759 Editor’s Highlights Abstract Sigma 1 Receptor (S1R) is a therapeutic target for a […]
Continue ReadingTargeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson’s Disease
By Talha Siddiqui and Lokesh Kumar Bhatt Excerpt from the article published in Neurochem Research. 31 May 2023. DOI: https://doi.org/10.1007/s11064-023-03960-6 Editor’s Highlights Abstract Parkinson’s disease is a neurodegenerative disease affecting mainly the elderly population. It is characterized by the loss of dopaminergic neurons of the substantia nigra pars compacta region. Parkinson’s disease patients exhibit motor […]
Continue ReadingTargeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
By Dicson S. Malar, Premrutai Thitilertdecha, Kanokphorn S. Ruckvongacheep, Sirikalaya Brimson, Tewin Tencomnao, and James M. Brimson Excerpt from the article published in CNS Drugs, May 2023. DOI: https://doi.org/10.1007/s40263-023-01007-6 Editor’s Highlights Abstract The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a genetically unrelated protein with […]
Continue ReadingInvestigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands
By Gianmarco Pascarella, Lorenzo Antonelli, Daniele Narzi, Theo Battista, Annarita Fiorillo, Gianni Colotti, Leonardo Guidoni, Veronica Morea, and Andrea Ilari Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6367. 28 March 2023. DOI: https://doi.org/10.3390/ijms24076367 Editor’s Highlights Abstract The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in […]
Continue ReadingSigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases
By Britney N. Lizama, Jennifer Kahle, Susan M. Catalano, Anthony O. Caggiano, Michael Grundman, and Mary E. Hamby Excerpt from the article published in the International Journal of Molecular Sciences. 24(7):6251. 26 March 2023. DOI: https://doi.org/10.3390/ijms24076251 Editor’s Highlights Abstract There is a large unmet medical need to develop disease-modifying treatment options for individuals with age-related […]
Continue ReadingThe Sigma Enigma: A Narrative Review of Sigma Receptors
By Joseph Pergolizzi, Giustino Varrassi, Mark Coleman, Frank Breve, Dana K. Christo, Paul J. Christo, and Charbel Moussa Excerpt from the article published in Cureus 15(3): e35756. March 04, 2023; doi: 10.7759/cureus.35756 Abstract The sigma-1 and sigma-2 receptors were first discovered in the 1960s and were thought to be a form of opioid receptors initially. […]
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