Category Archives: Cardiovascular

Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction

By Giuseppina Amodio, Ornella Moltedo, Raffaella Faraonio, and Paolo Remondelli Excerpt from the article published in Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 4946289, 13 pages, 14 Mar 2018. DOI: https://doi.org/10.1155/2018/4946289 Editor’s Highlights Abstract In endothelial cells, the tight control of the redox environment is essential for the maintenance of vascular homeostasis. The […]

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

By Jing Zhao, Barbara A. Mysona, Jing Wang, Graydon B. Gonsalvez, Sylvia B. Smith, and Kathryn E. Bollinger Excerpt from the article published in PLOS ONE, September 12, 2017, DOI: https://doi.org/10.1371/journal.pone.0184421 Editor’s Highlights Neuronal and glial cell types throughout the retina and optic nerve contain sigma 1 receptor (S1R), and its agonists display robust neuroprotective […]

Transit and integration of extracellular mitochondria in human heart cells

By Douglas B. Cowan, Rouan Yao, Jerusha K. Thedsanamoorthy, David Zurakowski, Pedro J. del Nido, and James D. McCully Excerpt from the article published in Scientific Reports 7, 17450 (2017). Published: 12 December 2017, DOI: https://doi.org/10.1038/s41598-017-17813-0 Editor’s Highlights Mitochondria play an essential role in energy production and cellular homeostasis. Dysfunction of these organelles as a result of ischemia […]

Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis

By Jennifer A. Felsted, Cheng-Hao Chien, Dongqing Wang, Micaella Panessiti, Dominique Ameroso, Andrew Greenberg, Guoping Feng, Dong Kong, and Maribel Rios Excerpt from the article published in Cell Reports, volume 21, issue 10, P2737-2747, December 2017, DOI: https://doi.org/10.1016/j.celrep.2017.11.048 Editor’s Highlights Alpha2delta-1 (α2δ-1) plays a chief role in energy and glucose balance control acting downstream of brain-derived neurotrophic […]