Cardiovascular - Advantx Pharmaceuticals Inc.

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection

By Jing Zhao; Graydon B. Gonsalvez; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger Excerpt from the article published in Investigative Ophthalmology & Visual Science February 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.2.1 Editor’s Highlights Abstract Purpose: Sigma 1 receptor (S1R) is expressed in retinal ganglion cells (RGCs) and astrocytes, and its activation is neuroprotective. We evaluated the contribution of S1R within optic […]

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

by Song, L., Bekdash, R., Morikawa, K. et al. Excerpt from the article published in Nat Cardiovasc Res 1, 142–156 (2022). https://doi.org/10.1038/s44161-021-00016-2 Editor’s Highlights Mutations in the CACNA1C gene, encoding the α2δ-1 subunit in the calcium channel CaV1.2, cause a life-threatening form of long QT syndrome (LQTS) named Timothy syndrome. SIGMA-1 receptor could be a therapeutic target for TS and […]

Sigma–1 receptor activation alleviates blood–brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF–GFRα1–RET pathway

By Danyang Liu, Luxi Yang, Peng Liu, Xuefei Ji, Xiaoxiao Qi, Ziqi Wang, Tianyan Chi, and Libo Zou Excerpt from the article published in Experimental Neurology, Volume 347, 2022, DOI: https://doi.org/10.1016/j.expneurol.2021.113867. Editors’ Highlights Sigma-1 receptor agonists could play an effective therapeutic role in preventing BBB damage in ischemic stroke and other cardiovascular conditions. Autors’ Highlights Sigma […]

The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes

by Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Naznin Sultana Remex, Mahboob Morshed, Sadia Nitu, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, James Traylor, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan Excerpt from the article published in Mitochondrion, Volume 62, 2022, Pages 159-175, ISSN 1567-7249, https://doi.org/10.1016/j.mito.2021.12.002. Editor’s Highlights […]

Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury

By Shi Mingming, Chen Fanglian, Chen Zhijuan, Yang Weidong, Yue Shuyuan, Zhang Jianning, and Chen Xin Excerpt from the article published in Frontiers in Cellular Neuroscience, 2021. DOI:10.3389/fncel.2021.685201 Editor’s Highlights Abstract The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a dynamic […]

Sigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma

By Linya Li, Shaoqing He, Yang Liu, Thomas Yorio, Dorette Z. Ellis Excerpt from the article published in Investigative Ophthalmology & Visual Science August 2021, Vol.62, 17. doi: https://doi.org/10.1167/iovs.62.10.17 Editor’s Highlights Degeneration of the retinal ganglion cells (RGCs), their axons, and optic nerves (ONs) are hallmarks in glaucoma. The Sigma-1R (σ-1r) is localized at the endoplasmic […]

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

By Aishwarya Richa, Abdullah Chowdhury S., Morshed Mahboob, Remex Naznin Sultana, and Bhuiyan Md. Shenuarin Excerpt from the article published in Frontiers in Physiology, volume 12, 2021. DOI: https://doi.org/10.3389/fphys.2021.705575 Editor’s Highlights Sigma-1 receptor is a multifunctional, ubiquitously expressed chaperone protein encoded by the SIGMAR1 gene. Alterations in Sigmar1’s subcellular localization, expression, and signaling have been […]

Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging

By Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa, Seigo Kinuya Excerpt from the article published in Circulation Journal, Article ID CJ-21-0320, Online ISSN 1347-4820, Print ISSN 1346-9843, DOI: https://doi.org/10.1253/circj.CJ-21-0320 Editor’s Highlights The sigma-1 receptor chaperone (σ1R) is considered as a pluripotent modulator with resultant multiple functional manifestations in […]

Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment

By Jing Qu, Miaoling Li, Dongxu Li, Yanguo Xin, Junli Li, Song Lei, Wenchao Wu, and Xiaojing Liu Excerpt from the article published in Oxidative medicine and cellular longevity vol. 2021 8836818. 4 Jan. 2021, DOI:10.1155/2021/8836818 Editor’s Highlights Cardiac fibrosis is a common pathological process in the development of various cardiovascular diseases and the risk for […]

Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics

By Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Mohammad Alfrad Nobel Bhuiyan, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Hanna Osinska, Jeffrey Robbins, John N. Lorenz, and Md. Shenuarin Bhuiyan Excerpt from the article published in Journal of the American Heart Association. 2018;7:e009775, 11 Oct 2018, DOI: https://doi.org/10.1161/JAHA.118.009775 Editor’s Highlights […]

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