Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells
By Yifei Zhang, Yixian Huang, Peng Zhang, Xiang Gao, Robert B Gibbs, and Song Li Excerpt from the article published in International Journal of Nanomedicine, 7: 4473-4485, 07 Dec 2022, DOI: 10.2147/IJN.S31981 Editor’s Highlights Abstract Background: The sigma-2 receptor is an attractive target for tumor imaging and targeted therapy because it is overexpressed in multiple types of solid tumors, […]
Continue ReadingProteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
By Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro Nakamura, Naoko […]
Continue ReadingInsights on the Role of PGRMC1 in Mitotic and Meiotic Cell Division
By Valentina Lodde, Rodrigo Garcia Barros, Laura Terzaghi, Federica Franciosi, and Alberto Maria Luciano Excerpt from the article published in Cancers 14, no. 23: 5755. 23 November 2022. DOI: https://doi.org/10.3390/cancers14235755 Editor’s Highlights Simple Summary PGRMC1 is a multifunctional protein regulating multiple aspects of cell proliferation, including cell viability, apoptosis, entry into the cell cycle, and the […]
Continue ReadingBrain Tumor Networks in Diffuse Glioma
By Yvonne Yang, Marc C. Schubert, Thomas Kuner, Wolfgang Wick, Frank Winkler, and Varun Venkataramani Excerpt from the article published in Neurotherapeutics, 10 November 2022. DOI: https://doi.org/10.1007/s13311-022-01320-w Editor’s Highlights Abstract Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and molecular mechanisms driving the invasive growth patterns and therapeutic resistance are incompletely […]
Continue ReadingCalcium channel α2δ1 is essential for pancreatic tumor-initiating cells through sequential phosphorylation of PKM2
By Jingtao Liu, Ming Tao, Wei Zhao, Qingru Song, Xiaodan Yang, Meng Li, Yanhua Zhang, Dianrong Xiu, and Zhiqian Zhang Journal Pre-proof to appear in Cellular and Molecular Gastroenterology and Hepatology. Accepted Date: 7 October 2022. DOI: https://doi.org/10.1016/j.jcmgh.2022.10.006 Abstract Background & Aims Tumor-initiating cells (TICs) drive pancreatic cancer tumorigenesis, therapeutic resistance and metastasis. However, TICs […]
Continue ReadingNovel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function
By Zhanwei Zeng, Shiyi Liao, Huan Zhou, Hongyu Liu, Jiantao Lin, Yunsheng Huang, Chenhui Zhou, and Daohua Xu Excerpt from the article published in Frontiers in Pharmacology, 31 August 2022, Sec. Pharmacology of Anti-Cancer Drugs, DOI: https://doi.org/10.3389/fphar.2022.952980 Editor’s Highlights Female breast cancer is one of the most common malignancies in the world, with an estimated 2.3 […]
Continue ReadingGPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1
By Dandan Ma, Wei Sun, Cuicui Fu, Kamran Nazmi, Enno C. I. Veerman, Richard T. Jaspers, Jan G. M. Bolscher, Floris J. Bikker, and Gang Wu Excerpt from the article published in International Journal of Oral Science volume 14, Article number: 42 (2022), 15 August 2022, DOI: https://doi.org/10.1038/s41368-022-00181-5 Editor’s Highlights The histatin (Hst) peptide family […]
Continue ReadingTMEM97 is transcriptionally activated by YY1 and promotes colorectal cancer progression via the GSK-3β/β-catenin signaling pathway
By Dong Mao, Xiaowei Zhang, Zhaoping Wang, Guannan Xu, and Yun Zhang Introduction to the article published in Human Cell (2022). 30 July 2022, DOI: https://doi.org/10.1007/s13577-022-00759-5 Editor’s Highlights Transmembrane protein 97 (TMEM97), also known as meningioma-associated protein (MAC30) or sigma-2 receptor functions in cell proliferation, apoptosis, migration, and invasion. Abstract Transmembrane protein 97 (TMEM97) is a conserved integral membrane protein highly […]
Continue ReadingPGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
By Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, and Kazuhiro Tamura Excerpt from the article published in Biomolecules 2022, 12, 1046, 28 July 2022, DOI: https://doi.org/10.3390/biom12081046 Editor’s Highlights The differentiation of endometrial stromal cells (ESCs) into decidual cells is essential for the acquisition of endometrial receptivity for implantation and subsequent […]
Continue ReadingHaloperidol Instigates Endometrial Carcinogenesis and Cancer Progression by the NF-κB/CSF-1 Signaling Cascade
By Jung-Ying Chiang, Fu-Ju Lei, Huan-Jui Chang, Sung-Tai Wei, Chi-Chung Wang, Yen-Chih Huang, Hwai-Lee Wang, Chi-Fen Chuang, Shu-Yu Hu and Chia-Hung Hsieh Excerpt from the article published in Cancers 2022, 14(13), 3089; Published: 23 June 2022, DOI https://doi.org/10.3390/cancers14133089 Editor’s Highlights Haloperidol restrains cell proliferation and initiates apoptosis in human melanoma, colon cancer, and breast cancer cells by binding […]
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